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Tbio
CHMP1B
Charged multivesicular body protein 1b

Protein Classes
Protein Summary
Description
Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane f ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000526991
  • ENSP00000432279
  • ENSG00000255112

Symbol
  • C18orf2
  • Vps46B
  • C10orf2
  • C18orf2
  • CHMP1.5
  • Vps46-2
  • C18-ORF2
  • hVps46-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.81
kinase perturbation
0.81
transcription factor binding site profile
0.78
interacting protein
0.74
transcription factor perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.72   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.72   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (25)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (61)
1 – 10 of 61
CHMP4B
Tbio
Novelty: 0.01391352
Score: 0.999
Data Source: STRINGDB
CHMP3
Tbio
Novelty: 0.01958573
Score: 0.999
Data Source: STRINGDB
IST1
Tbio
Novelty: 0.01780503
Score: 0.997
Data Source: STRINGDB
VTA1
Tbio
Novelty: 0.01697854
Score: 0.996
Data Source: STRINGDB
VPS4A
Tbio
Novelty: 0.01508121
Score: 0.993
Data Source: STRINGDB
CHMP6
Tbio
Novelty: 0.02931
Score: 0.99
Data Source: STRINGDB
CHMP4A
Tbio
Novelty: 0.01163844
Score: 0.987
Data Source: STRINGDB
SPAST
Tbio
Novelty: 0.00303236
Score: 0.984
Data Source: STRINGDB
VPS4B
Tbio
Novelty: 0.00788708
Score: 0.982
Data Source: STRINGDB
CHMP2A
Tbio
Novelty: 0.00169253
Score: 0.982
Data Source: STRINGDB
Publication Statistics
PubMed Score  12.72

PubMed score by year
PubTator Score  19.15

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer