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Tbio
MOB1B
MOB kinase activator 1B

Protein Summary
Description
Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L. The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309395
  • ENSP00000310189
  • ENSG00000173542
  • ENST00000396051
  • ENSP00000379366

Symbol
  • MOB4A
  • MOBKL1A
  • MATS2
  • MOB4A
  • MOBKL1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.84
microRNA
0.76
interacting protein
0.75
histone modification site profile
0.71
virus perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.45   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 332   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.45   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 332   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
4
2
1.1
82
viral load
1
1
1
65.4
mean corpuscular volume
1
1
1
46.9
red blood cell distribution width
1
1
1
46.1
mean reticulocyte volume
1
1
1
45.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.1
82
viral load
1
65.4
mean corpuscular volume
1
46.9
red blood cell distribution width
1
46.1
mean reticulocyte volume
1
45.7
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MOB kinase activator 1B
VGNC:13028
741698
Macaque
MOB kinase activator 1B
705155
Mouse
MGI:1915723
68473
Rat
RGD:1305114
360920
Dog
MOB kinase activator 1B
VGNC:43300
482187
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MOB kinase activator 1B
Macaque
MOB kinase activator 1B
Mouse
Rat
Dog
MOB kinase activator 1B
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q7L9L4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Signal Transduction (R-HSA-162582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Signal Transduction
Reactome
Signaling by Hippo
Name
Explore in Pharos
Explore in Source
Signal Transduction
Signaling by Hippo
Gene Ontology Terms (10)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (61)
1 – 10 of 61
LATS1
Tchem
Family:  Kinase
Novelty:  0.00369058
p_int:  1
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
LATS2
Tchem
Family:  Kinase
Novelty:  0.00521035
p_int:  1
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
MOB1A
Tbio
Family:  Enzyme
Novelty:  0.01430129
p_int:  1
Score:  0.985
Data Source:  BioPlex,STRINGDB
STK38L
Tchem
Family:  Kinase
Novelty:  0.05193219
p_int:  1
Score:  0.969
Data Source:  BioPlex,STRINGDB
STK38
Tchem
Family:  Kinase
Novelty:  0.03242123
p_int:  0.999999446
p_ni:  5.52e-7
p_wrong:  1e-9
Score:  0.895
Data Source:  BioPlex,STRINGDB
LRCH2
Tdark
Novelty:  1.90908316
p_int:  0.999762932
p_ni:  0.000237068
Score:  0.229
Data Source:  BioPlex,STRINGDB
DOCK7
Tbio
Novelty:  0.03425586
p_int:  0.999698368
p_ni:  0.000301632
Score:  0.343
Data Source:  BioPlex,STRINGDB
STK4
Tchem
Family:  Kinase
Novelty:  0.02104423
Score:  0.995
Data Source:  Reactome,STRINGDB
STK3
Tchem
Family:  Kinase
Novelty:  0.0529257
Score:  0.993
Data Source:  Reactome,STRINGDB
SAV1
Tbio
Novelty:  0.00962335
Score:  0.981
Data Source:  STRINGDB
Publication Statistics
PubMed Score  11.45

PubMed score by year
PubTator Score  2.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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