You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
VASH1
Tubulinyl-Tyr carboxypeptidase 1

Protein Summary
Description
Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function (PubMed:29146869). Acts as an angiogenesis inhibitor: inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis (PubMed:15467828, PubMed:16488400, PubMed:16707096, PubMed:19204325). This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts (PubMed:15467828, PubMed:16488400, PubMed:16707096).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000167106
  • ENSP00000167106
  • ENSG00000071246
  • ENST00000554237
  • ENSP00000451613

Symbol
  • KIAA1036
  • VASH
  • TTCP 1
  • KIAA1036
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.79
transcription factor perturbation
0.74
disease perturbation
0.62
PubMedID
0.62
microRNA
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.85   (req: < 5)
Gene RIFs: 51   (req: <= 3)
Antibodies: 261   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.85   (req: >= 5)
Gene RIFs: 51   (req: > 3)
Antibodies: 261   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (17)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (25)
1 – 10 of 25
AMY1A
Tchem
Family: Enzyme
Novelty: 0.00383591
p_int: 0.999618887
p_ni: 0.000381113
Data Source: BioPlex
RAB6B
Tbio
Family: Enzyme
Novelty: 0.07884363
p_int: 0.998386443
p_ni: 0.001613557
Score: 0.198
Data Source: BioPlex,STRINGDB
PAXX
Tbio
Novelty: 0.03117577
p_int: 0.99161982
p_ni: 0.008380098
p_wrong: 8.2e-8
Score: 0.416
Data Source: BioPlex,STRINGDB
RAP1GDS1
Tbio
Family: Enzyme
Novelty: 0.04627419
p_int: 0.891644523
p_ni: 0.108355477
Score: 0.536
Data Source: BioPlex,STRINGDB
RHOA
Tbio
Family: Enzyme
Novelty: 0.0002729
p_int: 0.876643912
p_ni: 0.107192376
p_wrong: 0.016163712
Score: 0.653
Data Source: BioPlex,STRINGDB
SVBP
Tdark
Novelty: 0.16260163
Score: 0.915
Data Source: STRINGDB
ANGEL1
Tbio
Novelty: 0.625
Score: 0.803
Data Source: STRINGDB
ELAVL4
Tbio
Novelty: 0.00276378
Score: 0.64
Data Source: STRINGDB
EZH2
Tclin
Family: Epigenetic
Novelty: 0.00057242
Score: 0.633
Data Source: STRINGDB
POMT2
Tbio
Family: Enzyme
Novelty: 0.03313606
Score: 0.572
Data Source: STRINGDB
Publication Statistics
PubMed Score  111.85

PubMed score by year
PubTator Score  61.12

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer