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Tbio
VASH1
Tubulinyl-Tyr carboxypeptidase 1

Protein Summary
Description
Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function (PubMed:29146869). Acts as an angiogenesis inhibitor: inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis (PubMed:15467828, PubMed:16488400, PubMed:16707096, PubMed:19204325). This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts (PubMed:15467828, PubMed:16488400, PubMed:16707096).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000167106
  • ENSP00000167106
  • ENSG00000071246
  • ENST00000554237
  • ENSP00000451613

Symbol
  • KIAA1036
  • VASH
  • TTCP 1
  • KIAA1036
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.79
transcription factor perturbation
0.74
disease perturbation
0.62
PubMedID
0.62
microRNA
0.61


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.75   (req: < 5)
Gene RIFs: 51   (req: <= 3)
Antibodies: 261   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.75   (req: >= 5)
Gene RIFs: 51   (req: > 3)
Antibodies: 261   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
vasohibin 1
703906
Mouse
MGI:2442543
238328
Rat
RGD:1564082
503052
Dog
vasohibin 1
VGNC:48233
490799
Horse
vasohibin 1
VGNC:24883
100051887
Species
Name
OMA
EggNOG
Inparanoid
Macaque
vasohibin 1
Mouse
Rat
Dog
vasohibin 1
Horse
vasohibin 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q7L8A9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (17)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (25)
1 – 10 of 25
AMY1A
Tchem
Family: Enzyme
Novelty: 0.00210045
p_int: 0.999618887
p_ni: 0.000381113
Data Source: BioPlex
RAB6B
Tbio
Family: Enzyme
Novelty: 0.0865097
p_int: 0.998386443
p_ni: 0.001613557
Score: 0.198
Data Source: BioPlex,STRINGDB
PAXX
Tbio
Novelty: 0.03754932
p_int: 0.99161982
p_ni: 0.008380098
p_wrong: 8.2e-8
Score: 0.416
Data Source: BioPlex,STRINGDB
RAP1GDS1
Tbio
Family: Enzyme
Novelty: 0.06140479
p_int: 0.891644523
p_ni: 0.108355477
Score: 0.536
Data Source: BioPlex,STRINGDB
RHOA
Tbio
Family: Enzyme
Novelty: 0.00022204
p_int: 0.876643912
p_ni: 0.107192376
p_wrong: 0.016163712
Score: 0.653
Data Source: BioPlex,STRINGDB
SVBP
Tbio
Novelty: 0.10292729
Score: 0.915
Data Source: STRINGDB
ANGEL1
Tbio
Novelty: 0.61303879
Score: 0.803
Data Source: STRINGDB
ELAVL4
Tbio
Novelty: 0.00260383
Score: 0.64
Data Source: STRINGDB
EZH2
Tclin
Family: Epigenetic
Novelty: 0.00052816
Score: 0.633
Data Source: STRINGDB
POMT2
Tbio
Family: Enzyme
Novelty: 0.0251595
Score: 0.572
Data Source: STRINGDB
Publication Statistics
PubMed Score  124.75

PubMed score by year
PubTator Score  61.12

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer