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Tbio
VASH1
Tubulinyl-Tyr carboxypeptidase 1

Protein Summary
Description
Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function (PubMed:29146869). Acts as an angiogenesis inhibitor: inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis (PubMed:15467828, PubMed:16488400, PubMed:16707096, PubMed:19204325). This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts (PubMed:15467828, PubMed:16488400, PubMed:16707096).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000167106
  • ENSP00000167106
  • ENSG00000071246
  • ENST00000554237
  • ENSP00000451613

Symbol
  • KIAA1036
  • VASH
  • TTCP 1
  • KIAA1036
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.79
transcription factor perturbation
0.74
disease perturbation
0.62
PubMedID
0.62
microRNA
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 127.1   (req: < 5)
Gene RIFs: 51   (req: <= 3)
Antibodies: 261   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 127.1   (req: >= 5)
Gene RIFs: 51   (req: > 3)
Antibodies: 261   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (25)
AMY1A
Tchem
Family:  Enzyme
Novelty:  0.00210045
p_int:  0.999618887
p_ni:  0.000381113
Data Source:  BioPlex
RAB6B
Tbio
Family:  Enzyme
Novelty:  0.0865097
p_int:  0.998386443
p_ni:  0.001613557
Score:  0.198
Data Source:  BioPlex,STRINGDB
PAXX
Tbio
Novelty:  0.03754932
p_int:  0.99161982
p_ni:  0.008380098
p_wrong:  8.2e-8
Score:  0.416
Data Source:  BioPlex,STRINGDB
RAP1GDS1
Tbio
Family:  Enzyme
Novelty:  0.06140479
p_int:  0.891644523
p_ni:  0.108355477
Score:  0.536
Data Source:  BioPlex,STRINGDB
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
p_int:  0.876643912
p_ni:  0.107192376
p_wrong:  0.016163712
Score:  0.653
Data Source:  BioPlex,STRINGDB
SVBP
Tbio
Novelty:  0.10292729
Score:  0.915
Data Source:  STRINGDB
ANGEL1
Tbio
Novelty:  0.61303879
Score:  0.803
Data Source:  STRINGDB
ELAVL4
Tbio
Novelty:  0.00260383
Score:  0.64
Data Source:  STRINGDB
EZH2
Tclin
Family:  Epigenetic
Novelty:  0.00052816
Score:  0.633
Data Source:  STRINGDB
POMT2
Tbio
Family:  Enzyme
Novelty:  0.0251595
Score:  0.572
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
2
46.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
46.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
vasohibin 1
703906
Mouse
MGI:2442543
238328
Rat
RGD:1564082
503052
Dog
vasohibin 1
VGNC:48233
490799
Horse
vasohibin 1
VGNC:24883
100051887
Species
Name
OMA
EggNOG
Inparanoid
Macaque
vasohibin 1
Mouse
Rat
Dog
vasohibin 1
Horse
vasohibin 1
Publication Statistics
PubMed Score 127.10
PubMed score by year
PubTator Score 61.12
PubTator score by year
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Related Publications
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PMID
Year
Title