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Tbio
RAB11FIP2
Rab11 family-interacting protein 2

Protein Summary
Description
A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355624
  • ENSP00000347839
  • ENSG00000107560
  • ENST00000369199
  • ENSP00000358200

Symbol
  • KIAA0941
  • nRip11
  • Rab11-FIP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
histone modification site profile
0.82
microRNA
0.74
disease perturbation
0.68
cell type or tissue
0.63


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAB11 family interacting protein 2
VGNC:12452
740554
Macaque
RAB11 family interacting protein 2
711468
Mouse
MGI:1922248
74998
Rat
RGD:1308538
308003
Dog
RAB11 family interacting protein 2
VGNC:45250
477834
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAB11 family interacting protein 2
Macaque
RAB11 family interacting protein 2
Mouse
Rat
Dog
RAB11 family interacting protein 2
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q7L804-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Aquaporin-mediated transport (R-HSA-445717)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Aquaporin-mediated transport
Reactome
Transport of small molecules
Reactome
Vasopressin regulates renal water homeostasis via Aquaporins
Name
Explore in Pharos
Explore in Source
Aquaporin-mediated transport
Transport of small molecules
Vasopressin regulates renal water homeostasis via Aquaporins
Protein-Protein Interactions (62)
1 – 10 of 62
RAB11A
Tbio
Family:  Enzyme
Novelty:  0.00153551
p_int:  1
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
RAB11B
Tbio
Family:  Enzyme
Novelty:  0.00557558
p_int:  1
Score:  0.98
Data Source:  BioPlex,STRINGDB
RAB25
Tbio
Family:  Enzyme
Novelty:  0.01889483
Score:  0.994
Data Source:  STRINGDB
MYO5B
Tbio
Novelty:  0.01302142
Score:  0.993
Data Source:  Reactome,STRINGDB
EHD1
Tbio
Novelty:  0.00817602
Score:  0.955
Data Source:  STRINGDB
AQP2
Tbio
Novelty:  0.00088471
Score:  0.942
Data Source:  STRINGDB
RAB11FIP5
Tbio
Novelty:  0.0264203
Score:  0.882
Data Source:  STRINGDB
RAB11FIP1
Tbio
Novelty:  0.0445306
Score:  0.88
Data Source:  STRINGDB
REPS1
Tbio
Novelty:  0.08952347
Score:  0.834
Data Source:  STRINGDB
RAB11FIP3
Tbio
Novelty:  0.07915085
Score:  0.818
Data Source:  STRINGDB
Publication Statistics
PubMed Score  18.00

PubMed score by year
PubTator Score  9.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer