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Tchem
TAOK1
Serine/threonine-protein kinase TAO1

Protein Summary
Description
Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261716
  • ENSP00000261716
  • ENSG00000160551
  • ENST00000536202
  • ENSP00000438819

Symbol
  • KIAA1361
  • MAP3K16
  • MARKK
  • PSK2
  • TAO1
  • KFC-B
  • MARKK
  • PSK-2
  • hKFC-B
  • hTAOK1
  • MAP3K16
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule
0.98
molecular function
0.96
small molecule perturbation
0.94
transcription factor perturbation
0.91
interacting protein
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.62   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 342   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.62   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 342   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
4
7
8
96.3
platelet count
2
4
3
3.3
92
alcohol abuse
2
2
4
73
liver fibrosis measurement
2
2
4
73
red blood cell distribution width
1
1
1
9.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
8
96.3
platelet count
3
3.3
92
alcohol abuse
4
73
liver fibrosis measurement
4
73
red blood cell distribution width
1
9.5
Pathways (102)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Gene Ontology Terms (36)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ARUK-UCL
Inferred from Direct Assay (IDA)
ARUK-UCL
Inferred from Direct Assay (IDA)
ARUK-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
ARUK-UCL
Inferred from Sequence or structural Similarity (ISS)
ARUK-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Non-traceable Author Statement (NAS)
HGNC
Non-traceable Author Statement (NAS)
HGNC
Protein-Protein Interactions (155)
1 – 10 of 155
STK25
Tchem
Family: Kinase
Novelty: 0.03229688
p_int: 0.999999259
p_ni: 7.22e-7
p_wrong: 1.9e-8
Score: 0.516
Data Source: BioPlex,STRINGDB
FAM206A
Tbio
Novelty: 0.01675868
p_int: 0.999998266
p_ni: 8.15e-7
p_wrong: 9.18e-7
Score: 0.379
Data Source: BioPlex,STRINGDB
MAP2K3
Tchem
Family: Kinase
Novelty: 0.00349605
Score: 0.952
Data Source: STRINGDB
BUB3
Tbio
Novelty: 0.00714143
Score: 0.94
Data Source: STRINGDB
BUB1
Tchem
Family: Kinase
Novelty: 0.00327514
Score: 0.937
Data Source: STRINGDB
BUB1B
Tbio
Family: Kinase
Novelty: 0.00239073
Score: 0.936
Data Source: STRINGDB
MAD2L1
Tbio
Novelty: 0.01623659
Score: 0.935
Data Source: STRINGDB
MAD1L1
Tbio
Novelty: 0.03550138
Score: 0.935
Data Source: STRINGDB
SGO1
Tbio
Novelty: 0.01115849
Score: 0.93
Data Source: STRINGDB
ZW10
Tbio
Novelty: 0.01680538
Score: 0.929
Data Source: STRINGDB
Publication Statistics
PubMed Score  56.62

PubMed score by year
PubTator Score  22.69

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer