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Tbio
HIST3H2A
Histone H2A type 3

Protein Summary
Description
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A f ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366695
  • ENSP00000355656
  • ENSG00000181218
  • ENST00000645741
  • ENSP00000493926
  • ENSG00000284841
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
cellular component
0.88
cell type or tissue
0.82
transcription factor binding site profile
0.79
histone modification site profile
0.78


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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.34   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 63   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.34   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2448458
319162
Horse
histone H2A type 3
100061017
Cow
histone cluster 3, H2a
538911
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Horse
histone H2A type 3
Cow
histone cluster 3, H2a
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q7L7L0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (14)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Deubiquitination
Reactome
HATs acetylate histones
Reactome
HDACs deacetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Deubiquitination
HATs acetylate histones
HDACs deacetylate histones
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (181)
1 – 10 of 181
HIST2H2BE
Tbio
Novelty: 0.00024381
Score: 0.989
Data Source: STRINGDB
HIST1H2BK
Tbio
Novelty: 0.12867647
Score: 0.988
Data Source: STRINGDB
HIST1H2BJ
Tbio
Novelty: 0.14308844
Score: 0.986
Data Source: STRINGDB
HIST1H2BL
Tdark
Novelty: 0.64500134
Score: 0.986
Data Source: STRINGDB
HIST1H2BH
Tbio
Novelty: 0.24404102
Score: 0.983
Data Source: STRINGDB
HIST3H3
Tbio
Novelty: 0.04915012
Score: 0.982
Data Source: STRINGDB
HIST1H2BO
Tdark
Novelty: 0.3427419
Score: 0.981
Data Source: STRINGDB
HIST1H3A
Tbio
Novelty: 0.00991842
Score: 0.98
Data Source: STRINGDB
HIST1H2BN
Tbio
Novelty: 0.02592521
Score: 0.98
Data Source: STRINGDB
HIST2H2AB
Tbio
Novelty: 0.06772132
Score: 0.979
Data Source: STRINGDB
Publication Statistics
PubMed Score  2.34

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer