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Tbio
LPCAT2
Lysophosphatidylcholine acyltransferase 2

Protein Summary
Description
Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-dependent. Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF). Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAF precursor. Under resting conditions, acyltransferase activity is preferred. Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases. Also catalyzes the conversion of 1-acyl-sn-glycero-3-phosphocholine to 1,2-diacyl-sn-glycero-3-phosphocholine. This gene encodes a member of the lysophospholipid acyltransferase family. The encoded enzyme may function in two ways: to catalyze the biosynthesis of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) from 1-O-alkyl-sn-glycero-3-phosphocholine, and ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262134
  • ENSP00000262134
  • ENSG00000087253

Symbol
  • AGPAT11
  • AYTL1
  • AYTL1
  • AGPAT11
  • LysoPAFAT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
transcription factor perturbation
0.84
microRNA
0.81
metabolite
0.8
interacting protein
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.6   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 176   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.6   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 176   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hormone measurement
1
1
1
28.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hormone measurement
1
28.5
Pathways (9)
Acyl chain remodelling of PC (R-HSA-1482788)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acyl chain remodelling of PC
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Phospholipid metabolism
Name
Explore in Pharos
Explore in Source
Acyl chain remodelling of PC
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Phospholipid metabolism
Gene Ontology Terms (14)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (113)
1 – 10 of 113
PPP4R3B
Tbio
Family: Enzyme
Novelty: 0.0185504
p_int: 0.998105525
p_ni: 0.001894048
p_wrong: 4.27e-7
Data Source: BioPlex
EMB
Tbio
Novelty: 0.00135577
p_int: 0.997380445
p_ni: 0.002512242
p_wrong: 0.000107313
Data Source: BioPlex
SURF1
Tbio
Novelty: 0.00717605
p_int: 0.996872014
p_ni: 0.003113568
p_wrong: 0.000014418
Data Source: BioPlex
SLC39A10
Tbio
Family: Transporter
Novelty: 0.03527885
p_int: 0.995436499
p_ni: 0.004563501
Data Source: BioPlex
ADGRL1
Tbio
Family: GPCR
Novelty: 0.00957739
p_int: 0.984717813
p_ni: 0.015282168
p_wrong: 1.9e-8
Data Source: BioPlex
HERC3
Tbio
Family: Enzyme
Novelty: 0.05231675
p_int: 0.981839469
p_ni: 0.01816053
p_wrong: 1e-9
Data Source: BioPlex
SLC39A6
Tbio
Family: Transporter
Novelty: 0.0144314
p_int: 0.972842848
p_ni: 0.027157152
Data Source: BioPlex
VMP1
Tbio
Novelty: 0.00997613
p_int: 0.923811057
p_ni: 0.075852487
p_wrong: 0.000336456
Data Source: BioPlex
NDUFAF1
Tclin
Novelty: 0.05630549
p_int: 0.91142184
p_ni: 0.08857816
Data Source: BioPlex
METTL9
Tdark
Family: Enzyme
Novelty: 0.20589257
p_int: 0.906989985
p_ni: 0.093010015
Data Source: BioPlex
Publication Statistics
PubMed Score  40.60

PubMed score by year
PubTator Score  10.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer