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Tbio
GET4
Golgi to ER traffic protein 4 homolog

Protein Summary
Description
As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20676083, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20676083, PubMed:28104892, PubMed:25535373). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome (PubMed:28104892). Similarly, the BAG6/BAT3 complex also functions as a s ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265857
  • ENSP00000265857
  • ENSG00000239857
  • ENST00000407192
  • ENSP00000385646

Symbol
  • C7orf20
  • CEE
  • TRC35
  • CEE
  • TRC35
  • CGI-20
  • C7orf20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.88
virus perturbation
0.79
gene perturbation
0.78
tissue sample
0.73
kinase perturbation
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.89   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 48   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.89   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 48   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (66)
UBL4A
Tbio
Novelty:  0.01278608
p_int:  0.998498408
p_ni:  0.001501592
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
RNF126
Tbio
Family:  Enzyme
Novelty:  0.08123801
p_int:  0.986359883
p_ni:  0.013640117
Score:  0.873
Data Source:  BioPlex,STRINGDB
UBL4B
Tdark
Novelty:  0.56877836
p_int:  0.949636523
p_ni:  0.050363477
Score:  0.448
Data Source:  BioPlex,STRINGDB
ABCA9
Tbio
Family:  Transporter
Novelty:  0.09458742
p_int:  0.940760225
p_ni:  0.059239775
Data Source:  BioPlex
FUZ
Tbio
Novelty:  0.03001976
p_int:  0.889501248
p_ni:  0.110498752
Score:  0.571
Data Source:  BioPlex,STRINGDB
ZP1
Tbio
Novelty:  0.16160314
p_int:  0.839195105
p_ni:  0.160804895
Data Source:  BioPlex
IL1RL2
Tbio
Novelty:  0.0156461
p_int:  0.831718554
p_ni:  0.168281446
Score:  0.199
Data Source:  BioPlex,STRINGDB
BAG6
Tbio
Novelty:  0.0035578
p_int:  0.820876519
p_ni:  0.179123481
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
NEGR1
Tbio
Novelty:  0.0088917
p_int:  0.800895729
p_ni:  0.199104271
Data Source:  BioPlex
SCN1B
Tbio
Family:  IC
Novelty:  0.00910273
p_int:  0.794186077
p_ni:  0.205813923
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane (R-HSA-9609523)

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Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Protein localization
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
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Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Disease Associations ()
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
2
3
3
90.1
C-reactive protein measurement
2
2
2
81.3
serum gamma-glutamyl transferase measurement
2
2
2
81.3
lymphocyte count
2
2
2
74.1
red blood cell distribution width
2
2
2
68.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
3
90.1
C-reactive protein measurement
2
81.3
serum gamma-glutamyl transferase measurement
2
81.3
lymphocyte count
2
74.1
red blood cell distribution width
2
68.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
golgi to ER traffic protein 4
VGNC:4367
463209
Macaque
golgi to ER traffic protein 4
696126
Mouse
MGI:1914854
67604
Rat
RGD:1311660
288518
Dog
golgi to ER traffic protein 4
VGNC:49779
491599
Species
Name
OMA
EggNOG
Inparanoid
Chimp
golgi to ER traffic protein 4
Macaque
golgi to ER traffic protein 4
Mouse
Rat
Dog
golgi to ER traffic protein 4
Publication Statistics
PubMed Score 26.89
PubMed score by year
PubTator Score 43.88
PubTator score by year
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Related Publications
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0 of 0
PMID
Text