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Tbio
DOK3
Docking protein 3

Protein Summary
Description
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312943
  • ENSP00000325174
  • ENSG00000146094
  • ENST00000357198
  • ENSP00000349727
  • ENST00000377112
  • ENSP00000366316

Symbol
  • DOKL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.67
kinase perturbation
0.66
tissue
0.6
virus perturbation
0.59
cell line
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.92   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 336   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.92   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 336   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (54)
TPP2
Tchem
Family:  Enzyme
Novelty:  0.00803674
p_int:  0.999967881
p_ni:  0.000032119
Score:  0.196
Data Source:  BioPlex,STRINGDB
UHRF1BP1L
Tbio
Novelty:  0.55650495
p_int:  0.994006562
p_ni:  0.005967077
p_wrong:  0.000026361
Score:  0.345
Data Source:  BioPlex,STRINGDB
MIOS
Tdark
Novelty:  0.04252507
p_int:  0.990980059
p_ni:  0.009019941
Score:  0.204
Data Source:  BioPlex,STRINGDB
AMD1
Tchem
Family:  Enzyme
Novelty:  0.00231813
p_int:  0.979600045
p_ni:  0.020399955
Score:  0.173
Data Source:  BioPlex,STRINGDB
WDR54
Tdark
Novelty:  1.19807122
p_int:  0.959332188
p_ni:  0.040667812
Score:  0.196
Data Source:  BioPlex,STRINGDB
DPP8
Tchem
Family:  Enzyme
Novelty:  0.00678793
p_int:  0.952344561
p_ni:  0.045965559
p_wrong:  0.00168988
Score:  0.196
Data Source:  BioPlex,STRINGDB
GRB2
Tchem
Novelty:  0.00091605
Score:  0.848
Data Source:  STRINGDB
BTK
Tclin
Family:  Kinase
Novelty:  0.00050747
Score:  0.821
Data Source:  STRINGDB
INPP5D
Tbio
Family:  Enzyme
Novelty:  0.00630254
Score:  0.801
Data Source:  STRINGDB
CSK
Tchem
Family:  Kinase
Novelty:  0.00186612
Score:  0.751
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
partial thromboplastin time
2
2
2
96.1
self reported educational attainment
2
3
3
88.3
blood metabolite measurement
2
1
2
77.4
mathematical ability
3
2
3
72.9
CHGB cleavage product measurement
1
1
1
71.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
partial thromboplastin time
2
96.1
self reported educational attainment
3
88.3
blood metabolite measurement
2
77.4
mathematical ability
3
72.9
CHGB cleavage product measurement
1
71.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1351490
27261
Rat
RGD:1311840
306760
Dog
docking protein 3
VGNC:40057
489087
Cow
docking protein 3
VGNC:28167
514894
Opossum
docking protein 3
100031925
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
docking protein 3
Cow
docking protein 3
Opossum
docking protein 3
Publication Statistics
PubMed Score 20.92
PubMed score by year
PubTator Score 19.05
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title