Tbio DOK3 Docking protein 3

Protein Summary

Description

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity).

Uniprot Accession IDs

• Q7L591
• E9PAT0
• H7BXS0
• Q8N864
• Q9BQB3
• Q9H666

Gene Name

• DOK3

Ensembl ID

• ENST00000312943
• ENSP00000325174
• ENSG00000146094
• ENST00000357198
• ENSP00000349727
• ENST00000377112
• ENSP00000366316

Symbol

• DOKL

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.67
kinase perturbation	0.66
tissue	0.6
virus perturbation	0.59
cell line	0.56

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.78   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 336   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.78   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 336   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0