Protein Summary
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity).
- ENST00000312943
- ENSP00000325174
- ENSG00000146094
- ENST00000357198
- ENSP00000349727
- ENST00000377112
- ENSP00000366316
- DOKL
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.67 | ||
kinase perturbation | 0.66 | ||
tissue | 0.6 | ||
virus perturbation | 0.59 | ||
cell line | 0.56 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 20.92 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 336 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 20.92 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 336 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (54)
TPP2
Family: Enzyme
Novelty: 0.00803674
p_int: 0.999967881
p_ni: 0.000032119
Score: 0.196
Data Source: BioPlex,STRINGDB
UHRF1BP1L
Novelty: 0.55650495
p_int: 0.994006562
p_ni: 0.005967077
p_wrong: 0.000026361
Score: 0.345
Data Source: BioPlex,STRINGDB
MIOS
Novelty: 0.04252507
p_int: 0.990980059
p_ni: 0.009019941
Score: 0.204
Data Source: BioPlex,STRINGDB
AMD1
Family: Enzyme
Novelty: 0.00231813
p_int: 0.979600045
p_ni: 0.020399955
Score: 0.173
Data Source: BioPlex,STRINGDB
WDR54
Novelty: 1.19807122
p_int: 0.959332188
p_ni: 0.040667812
Score: 0.196
Data Source: BioPlex,STRINGDB
DPP8
Family: Enzyme
Novelty: 0.00678793
p_int: 0.952344561
p_ni: 0.045965559
p_wrong: 0.00168988
Score: 0.196
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (6)
Reactome (3)
PathwayCommons (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | Neutrophil degranulation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Immune System | ||||
Innate Immune System | ||||
Neutrophil degranulation | ||||
Viral Interactions (0)
Gene Ontology Terms (5)
Components (3)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations ()
GWAS Traits (20)
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
partial thromboplastin time | 2 | 2 | 2 | 96.1 | |||||
self reported educational attainment | 2 | 3 | 3 | 88.3 | |||||
blood metabolite measurement | 2 | 1 | 2 | 77.4 | |||||
mathematical ability | 3 | 2 | 3 | 72.9 | |||||
CHGB cleavage product measurement | 1 | 1 | 1 | 71.6 | |||||
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
partial thromboplastin time | 2 | 96.1 | |||||
self reported educational attainment | 3 | 88.3 | |||||
blood metabolite measurement | 2 | 77.4 | |||||
mathematical ability | 3 | 72.9 | |||||
CHGB cleavage product measurement | 1 | 71.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (6)
1 – 5 of 6
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:1351490 | 27261 | ||||||
Rat | RGD:1311840 | 306760 | ||||||
Dog | docking protein 3 | VGNC:40057 | 489087 | |||||
Cow | docking protein 3 | VGNC:28167 | 514894 | |||||
Opossum | docking protein 3 | 100031925 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | docking protein 3 | |||||
Cow | docking protein 3 | |||||
Opossum | docking protein 3 | |||||
Publication Statistics
PubMed Score 20.92
PubMed score by year
PubTator Score 19.05
PubTator score by year
Related Publications
Text Mined References (21)
GeneRif Annotations (7)
Items per page:
0 of 0
PMID | Year | Title |
|---|