Protein Summary
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity).
- ENST00000312943
- ENSP00000325174
- ENSG00000146094
- ENST00000357198
- ENSP00000349727
- ENST00000377112
- ENSP00000366316
- DOKL
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
cell type or tissue | 0.67 | ||
kinase perturbation | 0.66 | ||
tissue | 0.6 | ||
virus perturbation | 0.59 | ||
cell line | 0.56 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 20.92 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 336 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 20.92 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 336 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (54)
TPP2
Family: Enzyme
Novelty: 0.00803674
p_int: 0.999967881
p_ni: 0.000032119
Score: 0.196
Data Source: BioPlex,STRINGDB
UHRF1BP1L
Novelty: 0.55650495
p_int: 0.994006562
p_ni: 0.005967077
p_wrong: 0.000026361
Score: 0.345
Data Source: BioPlex,STRINGDB
MIOS
Novelty: 0.04252507
p_int: 0.990980059
p_ni: 0.009019941
Score: 0.204
Data Source: BioPlex,STRINGDB
AMD1
Family: Enzyme
Novelty: 0.00231813
p_int: 0.979600045
p_ni: 0.020399955
Score: 0.173
Data Source: BioPlex,STRINGDB
WDR54
Novelty: 1.19807122
p_int: 0.959332188
p_ni: 0.040667812
Score: 0.196
Data Source: BioPlex,STRINGDB
DPP8
Family: Enzyme
Novelty: 0.00678793
p_int: 0.952344561
p_ni: 0.045965559
p_wrong: 0.00168988
Score: 0.196
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (6)
Reactome (3)
PathwayCommons (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | Neutrophil degranulation | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Immune System | ||||
Innate Immune System | ||||
Neutrophil degranulation | ||||
Viral Interactions (0)
Gene Ontology Terms (5)
Components (3)
Processes (2)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations ()
GWAS Traits (20)
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
partial thromboplastin time | 2 | 2 | 2 | 96.1 | |||||
self reported educational attainment | 2 | 3 | 3 | 88.3 | |||||
blood metabolite measurement | 2 | 1 | 2 | 77.4 | |||||
mathematical ability | 3 | 2 | 3 | 72.9 | |||||
CHGB cleavage product measurement | 1 | 1 | 1 | 71.6 | |||||
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
partial thromboplastin time | 2 | 96.1 | |||||
self reported educational attainment | 3 | 88.3 | |||||
blood metabolite measurement | 2 | 77.4 | |||||
mathematical ability | 3 | 72.9 | |||||
CHGB cleavage product measurement | 1 | 71.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (6)
1 – 5 of 6
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Mouse | MGI:1351490 | 27261 | ||||||
Rat | RGD:1311840 | 306760 | ||||||
Dog | docking protein 3 | VGNC:40057 | 489087 | |||||
Cow | docking protein 3 | VGNC:28167 | 514894 | |||||
Opossum | docking protein 3 | 100031925 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | docking protein 3 | |||||
Cow | docking protein 3 | |||||
Opossum | docking protein 3 | |||||
Publication Statistics
PubMed Score 20.92
PubMed score by year
PubTator Score 19.05
PubTator score by year
Related Publications
Text Mined References (21)
GeneRif Annotations (7)
Items per page:
0 of 0
PMID | Year | Title |
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