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Tbio
MCM10
Protein MCM10 homolog

Protein Summary
Description
Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. Key effector of the RBBP6 and ZBTB38-mediated regulation of DNA-replication and common fragile sites stability; acts as a direct target of transcriptional repression by ZBTB38 (PubMed:24726359). The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378714
  • ENSP00000367986
  • ENSG00000065328
  • ENST00000484800
  • ENSP00000418268

Symbol
  • CNA43
  • DNA43
  • PRO2249
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
kinase perturbation
0.88
histone modification site profile
0.87
gene perturbation
0.84
small molecule perturbation
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.92   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 137   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.92   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (257)
1 – 10 of 257
DISC1
Tbio
Novelty:  0.00183442
p_int:  0.999981355
p_ni:  0.000018645
Data Source:  BioPlex
IKZF5
Tbio
Family:  TF
Novelty:  0.36596327
p_int:  0.999968429
p_ni:  0.000031571
Data Source:  BioPlex
CAV3
Tbio
Novelty:  0.00190092
p_int:  0.999946879
p_ni:  0.000053121
Data Source:  BioPlex
KLHL40
Tbio
Novelty:  0.0432945
p_int:  0.999918908
p_ni:  0.000081092
p_wrong:  1e-9
Score:  0.305
Data Source:  BioPlex,STRINGDB
TMEM171
Tdark
Novelty:  2.00247773
p_int:  0.999912572
p_ni:  0.000087428
Score:  0.257
Data Source:  BioPlex,STRINGDB
TPH1
Tclin
Family:  Enzyme
Novelty:  0.00098637
p_int:  0.999733412
p_ni:  0.000266588
Score:  0.254
Data Source:  BioPlex,STRINGDB
RELL2
Tbio
Novelty:  0.59290726
p_int:  0.999643526
p_ni:  0.000356473
p_wrong:  1e-9
Data Source:  BioPlex
CACNG5
Tdark
Family:  IC
Novelty:  0.52705448
p_int:  0.998139955
p_ni:  0.001860045
Data Source:  BioPlex
EVA1B
Tdark
Novelty:  2.1380272
p_int:  0.994727124
p_ni:  0.005272605
p_wrong:  2.71e-7
Data Source:  BioPlex
MICB
Tbio
Novelty:  0.00364639
p_int:  0.991919494
p_ni:  0.008080044
p_wrong:  4.61e-7
Data Source:  BioPlex
Pathways (12)
Activation of ATR in response to replication stress (R-HSA-176187)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of ATR in response to replication stress
Reactome
Activation of the pre-replicative complex
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Activation of ATR in response to replication stress
Activation of the pre-replicative complex
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Gene Ontology Terms (15)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
0
1.6
82
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.6
82
Find similar targets by:
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
minichromosome maintenance 10 replication initiation factor
695568
Mouse
MGI:1917274
70024
Rat
RGD:1311330
307126
Dog
minichromosome maintenance 10 replication initiation factor
VGNC:43080
487128
Cow
minichromosome maintenance 10 replication initiation factor
VGNC:31307
527595
Species
Name
OMA
EggNOG
Inparanoid
Macaque
minichromosome maintenance 10 replication initiation factor
Mouse
Rat
Dog
minichromosome maintenance 10 replication initiation factor
Cow
minichromosome maintenance 10 replication initiation factor
Publication Statistics
PubMed Score 88.92
PubMed score by year
PubTator Score 37.05
PubTator score by year