Tbio CYFIP1 Cytoplasmic FMR1-interacting protein 1

Protein Summary

Description

Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). May act as an invasion suppressor in cancers. This gene encodes a protein that regulates cytoskeletal dynamics and protein translation. The encoded protein is a component of the WAVE regulatory complex (WRC), which promotes actin polymerization.This protein also interacts with the Fragile X mental retardation protein (FMRP) and translation initiation factor 4E to inhibit protein translation. A large chromosomal deletion including this gene is associated with increased risk of schizophrenia and epilepsy in human patients. Reduced expression of this gene has been observed in various human cancers and the encoded protein may inhibit tumor invasion. [provided by RefSeq, May 2017]

Uniprot Accession IDs

• Q7L576
• A8K6D9
• Q14467
• Q5IED0
• Q6ZSX1
• Q9BSD9
• Q9BVC7

Gene Name

• CYFIP1

Ensembl ID

• ENST00000610365
• ENSP00000478779
• ENSG00000273749
• ENST00000617556
• ENSP00000480525
• ENST00000617928
• ENSP00000481038

Symbol

• KIAA0068
• SHYC
• SRA1
• SRA-1
• P140SRA-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.9
virus perturbation	0.9
disease perturbation	0.87
kinase perturbation	0.84
cellular component	0.76

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein Modulator / Cytoplasmic Fmr1-interacting Protein 1

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Cytoplasmic Fmr1-interacting Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.91   (req: < 5)

Gene RIFs: 27   (req: <= 3)

Antibodies: 100   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.91   (req: >= 5)

Gene RIFs: 27   (req: > 3)

Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0