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Tbio
CYFIP1
Cytoplasmic FMR1-interacting protein 1

Protein Summary
Description
Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). May act as an invasion suppressor in cancers. This gene encodes a protein that regulates cytoskeletal dynamics and protein translation. The encoded protein is a component of the WAVE regulatory complex (WRC), wh ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000610365
  • ENSP00000478779
  • ENSG00000273749
  • ENST00000617556
  • ENSP00000480525
  • ENST00000617928
  • ENSP00000481038

Symbol
  • KIAA0068
  • SHYC
  • SRA1
  • SRA-1
  • P140SRA-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
virus perturbation
0.9
disease perturbation
0.87
kinase perturbation
0.84
cellular component
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.94   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 100   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.94   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
1
2
74
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
74
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (20)
Fcgamma receptor (FCGR) dependent phagocytosis (R-HSA-2029480)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fcgamma receptor (FCGR) dependent phagocytosis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Reactome
RHO GTPase Effectors
Name
Explore in Pharos
Explore in Source
Fcgamma receptor (FCGR) dependent phagocytosis
Immune System
Innate Immune System
Neutrophil degranulation
RHO GTPase Effectors
Gene Ontology Terms (53)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (249)
1 – 10 of 249
BRK1
Tbio
Novelty: 0.02289534
p_int: 0.999992732
p_ni: 0.000007268
Score: 0.999
Data Source: BioPlex,STRINGDB
NCKAP1
Tbio
Novelty: 0.03486454
p_int: 0.999987666
p_ni: 0.000012334
Score: 0.999
Data Source: BioPlex,STRINGDB
ABI2
Tbio
Novelty: 0.02324355
p_int: 0.999936577
p_ni: 0.000063423
Score: 0.999
Data Source: BioPlex,STRINGDB
NCK2
Tbio
Novelty: 0.02220251
p_int: 0.999678154
p_ni: 0.000321846
Score: 0.578
Data Source: BioPlex,STRINGDB
TIMM50
Tbio
Family: Enzyme
Novelty: 0.0238053
p_int: 0.994518104
p_ni: 0.005481896
Score: 0.645
Data Source: BioPlex,STRINGDB
NCK1
Tbio
Novelty: 0.00352084
p_int: 0.992476507
p_ni: 0.007523493
Score: 0.936
Data Source: BioPlex,STRINGDB
AMZ1
Tdark
Family: Enzyme
Novelty: 0.246305
p_int: 0.98225275
p_ni: 0.01774725
Score: 0.666
Data Source: BioPlex,STRINGDB
EPS8L1
Tbio
Family: Enzyme
Novelty: 0.15959644
p_int: 0.975082476
p_ni: 0.024917524
Data Source: BioPlex
ZNF511
Tdark
Novelty: 1.07235474
p_int: 0.964906786
p_ni: 0.035093214
Score: 0.527
Data Source: BioPlex,STRINGDB
ARHGAP12
Tbio
Family: Enzyme
Novelty: 0.12113722
p_int: 0.960053027
p_ni: 0.039946973
Data Source: BioPlex
Publication Statistics
PubMed Score  62.94

PubMed score by year
PubTator Score  28.43

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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