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Tbio
FCRLA
Fc receptor-like A

Protein Summary
Description
May be implicated in B-cell differentiation and lymphomagenesis. This gene encodes a protein similar to receptors for the Fc fragment of gamma immunoglobulin (IgG). These receptors, referred to as FCGRs, mediate the destruction of IgG-coated antigens and of cells induced by antibodies. This encoded protein is selectively expressed in B cells, and may be involved in their development. This protein may also be involved in the development of lymphomas. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000236938
  • ENSP00000236938
  • ENSG00000132185
  • ENST00000294796
  • ENSP00000294796
  • ENST00000309691
  • ENSP00000309596
  • ENST00000349527
  • ENSP00000294798
  • ENST00000350710
  • ENSP00000344808
  • ENST00000367949
  • ENSP00000356926
  • ENST00000367953
  • ENSP00000356930
  • ENST00000367957
  • ENSP00000356934
  • ENST00000367959
  • ENSP00000356936
  • ENST00000540521
  • ENSP00000442870
  • ENST00000546024
  • ENSP00000439838

Symbol
  • FCRL
  • FCRL1
  • FCRLM1
  • FCRX
  • FREB
  • FCRL
  • FCRX
  • FREB
  • FCRL1
  • FCRLX
  • FCRLb
  • FCRLd
  • FCRLe
  • FCRLM1
  • FCRLc1
  • FCRLc2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.93
tissue sample
0.71
gene perturbation
0.68
kinase perturbation
0.48
tissue
0.47


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.78   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.78   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (2)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Protein-Protein Interactions (28)
1 – 10 of 28
CD19
Tclin
Novelty: 0.00031194
Score: 0.852
Data Source: STRINGDB
VPREB3
Tbio
Novelty: 0.18095648
Score: 0.824
Data Source: STRINGDB
CD79B
Tclin
Novelty: 0.00265318
Score: 0.77
Data Source: STRINGDB
CD79A
Tbio
Novelty: 0.00192293
Score: 0.768
Data Source: STRINGDB
MEIS1
Tbio
Family: TF
Novelty: 0.00603843
Score: 0.759
Data Source: STRINGDB
NUP98
Tbio
Family: Enzyme
Novelty: 0.0050582
Score: 0.718
Data Source: STRINGDB
HOXA9
Tbio
Family: TF
Novelty: 0.00324615
Score: 0.718
Data Source: STRINGDB
BLK
Tchem
Family: Kinase
Novelty: 0.00922757
Score: 0.712
Data Source: STRINGDB
MS4A1
Tclin
Novelty: 0.01139952
Score: 0.677
Data Source: STRINGDB
TNFRSF13C
Tbio
Novelty: 0.00319386
Score: 0.607
Data Source: STRINGDB
Publication Statistics
PubMed Score  39.78

PubMed score by year
PubTator Score  39.28

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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