Tbio MIGA2 Mitoguardin 2

Protein Summary

Description

Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD.

Uniprot Accession IDs

• Q7L4E1
• Q8NBM3
• Q8TEJ6
• Q969E6

Gene Name

• MIGA2

Ensembl ID

• ENST00000358369
• ENSP00000351138
• ENSG00000148343
• ENST00000439290
• ENSP00000391603
• ENST00000445183
• ENSP00000396618

Symbol

• C9orf54
• FAM73B
• FAM73B
• C9orf54

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.73   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 21   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.73   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 21   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (31)

Explore Interacting Targets

1 – 10 of 31

• See Interactions on String-DB

VAPB

Tbio

Novelty:  0.00542377

p_int:  0.999999343

p_ni:  4.45e-7

p_wrong:  2.12e-7

Score:  0.19

Data Source:  BioPlex,STRINGDB

VAPA

Tbio

Novelty:  0.00169209

p_int:  0.999999159

p_ni:  8.41e-7

Data Source:  BioPlex

SIGLECL1

Tdark

p_int:  0.999997542

p_ni:  0.000002398

p_wrong:  6e-8

Data Source:  BioPlex

UBB

Tbio

Novelty:  0.00661254

p_int:  0.999385994

p_ni:  0.000614006

Data Source:  BioPlex

HSPA8

Tchem

Novelty:  0.00081014

p_int:  0.964775282

p_ni:  0.035224718

Data Source:  BioPlex

NIF3L1

Tbio

Novelty:  0.15581813

p_int:  0.954864326

p_ni:  0.045135225

p_wrong:  4.49e-7

Score:  0.169

Data Source:  BioPlex,STRINGDB

SLC27A2

Tbio

Family:  Transporter

Novelty:  0.01436035

p_int:  0.873280089

p_ni:  0.126719911

Data Source:  BioPlex

HSPA2

Tchem

Novelty:  0.01696667

p_int:  0.818476733

p_ni:  0.181523267

Score:  0.527

Data Source:  BioPlex,STRINGDB

UBR4

Tbio

Family:  Enzyme

Novelty:  0.03924839

p_int:  0.803609867

p_ni:  0.196390133

Data Source:  BioPlex

MIGA1

Tbio

Novelty:  0.08346483

Score:  0.909

Data Source:  Reactome,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (5)

Reactome (5)

Glycerophospholipid biosynthesis (R-HSA-1483206)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Glycerophospholipid biosynthesis	129 targets	R-HSA-1483206
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of lipids	740 targets	R-HSA-556833
Reactome	Phospholipid metabolism	211 targets	R-HSA-1483257
Reactome	Synthesis of PA	39 targets	R-HSA-1483166

Name	Explore in Pharos	Explore in Source
Glycerophospholipid biosynthesis	129 targets	R-HSA-1483206
Metabolism	2112 targets	R-HSA-1430728
Metabolism of lipids	740 targets	R-HSA-556833
Phospholipid metabolism	211 targets	R-HSA-1483257
Synthesis of PA	39 targets	R-HSA-1483166

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (6)

Functions (2)

Components (2)

Processes (2)

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10

1 – 2 of 2

GO Term	Evidence	Assigned by
protein heterodimerization activity	Inferred from Direct Assay (IDA)	UniProtKB
protein homodimerization activity	Inferred from Direct Assay (IDA)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (9)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 9

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
blood metabolite measurement	EFO_0005664	3	4	7		98.1
red blood cell distribution width	EFO_0005192	4	3	4		95.2
urinary metabolite measurement	EFO_0005116	1	1	1		61.4
red blood cell density measurement	EFO_0007978	1	1	1		53.3
hypersomnia	EFO_0005246	1	1	0	2.6	26.6

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 9

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
blood metabolite measurement	EFO_0005664	7		98.1
red blood cell distribution width	EFO_0005192	4		95.2
urinary metabolite measurement	EFO_0005116	1		61.4
red blood cell density measurement	EFO_0007978	1		53.3
hypersomnia	EFO_0005246	0	2.6	26.6

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Membrane
Mitochondrion
Mitochondrion outer membrane
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix

GWAS Trait Find Similar Targets

No Header	No Header
blood metabolite measurement
daytime rest measurement
diet measurement
hemoglobin measurement
hypersomnia
mean reticulocyte volume
red blood cell density measurement
red blood cell distribution width
urinary metabolite measurement

MGI Phenotype Find Similar Targets

No Header	No Header
adipose tissue phenotype
behavior/neurological phenotype
craniofacial phenotype
growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
skeleton phenotype

IDG Resources

No IDG generated resources found

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	mitoguardin 2	VGNC:4695	742027
Macaque	mitoguardin 2		722577
Mouse	mitoguardin 2	MGI:1922035	108958
Dog	mitoguardin 2	VGNC:43233	491305
Horse	mitoguardin 2	VGNC:20186	100070092

Species	Name	OMA	EggNOG	Inparanoid
Chimp	mitoguardin 2
Macaque	mitoguardin 2
Mouse	mitoguardin 2
Dog	mitoguardin 2
Horse	mitoguardin 2

Publication Statistics

PubMed Score 4.73

PubMed score by year

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PubTator Score 1.17

PubTator score by year

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Related Publications

Text Mined References (6)

GeneRif Annotations (1)

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10

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PMID	Year	Title