You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
MIGA2
Mitoguardin 2

Protein Summary
Description
Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358369
  • ENSP00000351138
  • ENSG00000148343
  • ENST00000439290
  • ENSP00000391603
  • ENST00000445183
  • ENSP00000396618

Symbol
  • C9orf54
  • FAM73B
  • FAM73B
  • C9orf54
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.73   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 21   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.73   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 21   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (31)
VAPB
Tbio
Novelty:  0.00542377
p_int:  0.999999343
p_ni:  4.45e-7
p_wrong:  2.12e-7
Score:  0.19
Data Source:  BioPlex,STRINGDB
VAPA
Tbio
Novelty:  0.00169209
p_int:  0.999999159
p_ni:  8.41e-7
Data Source:  BioPlex
SIGLECL1
Tdark
p_int:  0.999997542
p_ni:  0.000002398
p_wrong:  6e-8
Data Source:  BioPlex
UBB
Tbio
Novelty:  0.00661254
p_int:  0.999385994
p_ni:  0.000614006
Data Source:  BioPlex
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.964775282
p_ni:  0.035224718
Data Source:  BioPlex
NIF3L1
Tbio
Novelty:  0.15581813
p_int:  0.954864326
p_ni:  0.045135225
p_wrong:  4.49e-7
Score:  0.169
Data Source:  BioPlex,STRINGDB
SLC27A2
Tbio
Family:  Transporter
Novelty:  0.01436035
p_int:  0.873280089
p_ni:  0.126719911
Data Source:  BioPlex
HSPA2
Tchem
Novelty:  0.01696667
p_int:  0.818476733
p_ni:  0.181523267
Score:  0.527
Data Source:  BioPlex,STRINGDB
UBR4
Tbio
Family:  Enzyme
Novelty:  0.03924839
p_int:  0.803609867
p_ni:  0.196390133
Data Source:  BioPlex
MIGA1
Tbio
Novelty:  0.08346483
Score:  0.909
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Glycerophospholipid biosynthesis (R-HSA-1483206)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Phospholipid metabolism
Reactome
Synthesis of PA
Name
Explore in Pharos
Explore in Source
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Phospholipid metabolism
Synthesis of PA
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
3
4
7
98.1
red blood cell distribution width
4
3
4
95.2
urinary metabolite measurement
1
1
1
61.4
red blood cell density measurement
1
1
1
53.3
1
1
0
2.6
26.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
7
98.1
red blood cell distribution width
4
95.2
urinary metabolite measurement
1
61.4
red blood cell density measurement
1
53.3
0
2.6
26.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitoguardin 2
VGNC:4695
742027
Macaque
mitoguardin 2
722577
Mouse
MGI:1922035
108958
Dog
mitoguardin 2
VGNC:43233
491305
Horse
mitoguardin 2
VGNC:20186
100070092
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitoguardin 2
Macaque
mitoguardin 2
Mouse
Dog
mitoguardin 2
Horse
mitoguardin 2
Publication Statistics
PubMed Score 4.73
PubMed score by year
PubTator Score 1.17
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title