Protein Summary
Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD.
- ENST00000358369
- ENSP00000351138
- ENSG00000148343
- ENST00000439290
- ENSP00000391603
- ENST00000445183
- ENSP00000396618
- C9orf54
- FAM73B
- FAM73B
- C9orf54
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 0 | ||
biological term | 0 | ||
cell line | 0 | ||
cell type or tissue | 0 | ||
cellular component | 0 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4.73 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 21 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4.73 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 21 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (31)
VAPB
Novelty: 0.00542377
p_int: 0.999999343
p_ni: 4.45e-7
p_wrong: 2.12e-7
Score: 0.19
Data Source: BioPlex,STRINGDB
NIF3L1
Novelty: 0.15581813
p_int: 0.954864326
p_ni: 0.045135225
p_wrong: 4.49e-7
Score: 0.169
Data Source: BioPlex,STRINGDB
SLC27A2
Family: Transporter
Novelty: 0.01436035
p_int: 0.873280089
p_ni: 0.126719911
Data Source: BioPlex
HSPA2
Novelty: 0.01696667
p_int: 0.818476733
p_ni: 0.181523267
Score: 0.527
Data Source: BioPlex,STRINGDB
UBR4
Family: Enzyme
Novelty: 0.03924839
p_int: 0.803609867
p_ni: 0.196390133
Data Source: BioPlex
Nearest Tclin Targets
Pathways (5)
Reactome (5)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Glycerophospholipid biosynthesis | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of lipids | ||||
Reactome | Phospholipid metabolism | ||||
Reactome | Synthesis of PA | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Glycerophospholipid biosynthesis | ||||
Metabolism | ||||
Metabolism of lipids | ||||
Phospholipid metabolism | ||||
Synthesis of PA | ||||
Viral Interactions (0)
Gene Ontology Terms (6)
Functions (2)
Components (2)
Processes (2)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Disease Associations ()
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
blood metabolite measurement | 3 | 4 | 7 | 98.1 | |||||
red blood cell distribution width | 4 | 3 | 4 | 95.2 | |||||
urinary metabolite measurement | 1 | 1 | 1 | 61.4 | |||||
red blood cell density measurement | 1 | 1 | 1 | 53.3 | |||||
1 | 1 | 0 | 2.6 | 26.6 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
blood metabolite measurement | 7 | 98.1 | |||||
red blood cell distribution width | 4 | 95.2 | |||||
urinary metabolite measurement | 1 | 61.4 | |||||
red blood cell density measurement | 1 | 53.3 | |||||
0 | 2.6 | 26.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | mitoguardin 2 | VGNC:4695 | 742027 | |||||
Macaque | mitoguardin 2 | 722577 | ||||||
Mouse | MGI:1922035 | 108958 | ||||||
Dog | mitoguardin 2 | VGNC:43233 | 491305 | |||||
Horse | mitoguardin 2 | VGNC:20186 | 100070092 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | mitoguardin 2 | |||||
Macaque | mitoguardin 2 | |||||
Mouse | ||||||
Dog | mitoguardin 2 | |||||
Horse | mitoguardin 2 | |||||
Publication Statistics
PubMed Score 4.73
PubMed score by year
PubTator Score 1.17
PubTator score by year
Related Publications
Text Mined References (6)
GeneRif Annotations (1)
Items per page:
0 of 0
PMID | Year | Title |
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