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Tbio
CDC37L1
Hsp90 co-chaperone Cdc37-like 1

Protein Summary
Description
Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90. CDC37L1 is a cytoplasmic phosphoprotein that exists in complex with HSP90 (HSPCA; MIM 140571) as well as several other proteins involved in HSP90-mediated protein folding (Scholz et al., 2001 [PubMed 11413142]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381854
  • ENSP00000371278
  • ENSG00000106993

Symbol
  • CDC37B
  • HARC
  • HARC
  • CDC37B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
histone modification site profile
0.89
transcription factor binding site profile
0.85
disease perturbation
0.74
kinase perturbation
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.25   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 176   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.25   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 176   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (59)
FKBP6
Tbio
Family:  Enzyme
Novelty:  0.02240256
p_int:  0.999998677
p_ni:  0.000001053
p_wrong:  2.69e-7
Score:  0.311
Data Source:  BioPlex,STRINGDB
STK35
Tchem
Family:  Kinase
Novelty:  0.19556072
p_int:  0.99999015
p_ni:  3.31e-7
p_wrong:  0.000009519
Score:  0.285
Data Source:  BioPlex,STRINGDB
HSP90AB1
Tchem
Novelty:  0.00907961
p_int:  0.999857102
p_ni:  3.05e-7
p_wrong:  0.000142592
Score:  0.852
Data Source:  BioPlex,STRINGDB
HSP90AA1
Tchem
Novelty:  0.00016774
Score:  0.918
Data Source:  STRINGDB
FAM3C
Tbio
Novelty:  0.04598347
Score:  0.901
Data Source:  STRINGDB
APOH
Tbio
Novelty:  0.00049117
Score:  0.9
Data Source:  STRINGDB
LGALS3BP
Tbio
Novelty:  0.0025302
Score:  0.9
Data Source:  STRINGDB
TIMP3
Tbio
Family:  Enzyme
Novelty:  0.00134742
Score:  0.9
Data Source:  STRINGDB
CLEC3B
Tbio
Novelty:  0.0037534
Score:  0.9
Data Source:  STRINGDB
SERPINA4
Tbio
Novelty:  0.00483207
Score:  0.9
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Reactome
Platelet degranulation
Reactome
Response to elevated platelet cytosolic Ca2+
Name
Explore in Pharos
Explore in Source
Hemostasis
Platelet activation, signaling and aggregation
Platelet degranulation
Response to elevated platelet cytosolic Ca2+
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
11
8
10
4.9
99.6
platelet crit
2
5
7
99
neutrophil count
3
3
5
91.4
mean platelet volume
2
2
2
78.2
liver fibrosis measurement
3
2
6
76.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
10
4.9
99.6
platelet crit
7
99
neutrophil count
5
91.4
mean platelet volume
2
78.2
liver fibrosis measurement
6
76.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cell division cycle 37 like 1
VGNC:8806
473161
Macaque
cell division cycle 37 like 1
694831
Mouse
MGI:1914322
67072
Rat
RGD:1309295
293886
Dog
cell division cycle 37 like 1
VGNC:38995
476341
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cell division cycle 37 like 1
Macaque
cell division cycle 37 like 1
Mouse
Rat
Dog
cell division cycle 37 like 1
Publication Statistics
PubMed Score 10.25
PubMed score by year
PubTator Score 6.28
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title