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Tbio
CENPQ
Centromere protein Q

Protein Summary
Description
Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex (PubMed:16622420). Plays an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores (PubMed:25395579). CENPQ is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335783
  • ENSP00000337289
  • ENSG00000031691

Symbol
  • C6orf139
  • CENP-Q
  • C6orf139
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
cell type or tissue
0.68
tissue sample
0.66
transcription factor binding site profile
0.61
cellular component
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.23   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 131   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.23   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (149)
1 – 10 of 149
CENPP
Tbio
Novelty:  0.29282259
p_int:  0.999999501
p_ni:  4.94e-7
p_wrong:  5e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
ITGB3BP
Tbio
Novelty:  0.06162186
p_int:  0.999998314
p_ni:  0.000001684
p_wrong:  2e-9
Score:  0.998
Data Source:  BioPlex,STRINGDB
CENPO
Tbio
Novelty:  0.12059767
p_int:  0.999986802
p_ni:  0.000013198
Score:  0.999
Data Source:  BioPlex,STRINGDB
CENPU
Tbio
Novelty:  0.03681625
p_int:  0.999913743
p_ni:  0.000086256
p_wrong:  1e-9
Score:  0.997
Data Source:  BioPlex,STRINGDB
H2AFY2
Tbio
Novelty:  0.09948698
p_int:  0.996161556
p_ni:  0.00383212
p_wrong:  0.000006324
Data Source:  BioPlex
DGCR8
Tbio
Novelty:  0.00271221
p_int:  0.985133169
p_ni:  0.014861582
p_wrong:  0.000005249
Score:  0.392
Data Source:  BioPlex,STRINGDB
HEATR3
Tbio
Novelty:  0.08367436
p_int:  0.962565255
p_ni:  0.037429128
p_wrong:  0.000005618
Data Source:  BioPlex
RPL7A
Tbio
Novelty:  0.01674027
p_int:  0.828209762
p_ni:  0.170634348
p_wrong:  0.001155889
Data Source:  BioPlex
RPL11
Tbio
Novelty:  0.00448962
p_int:  0.763462711
p_ni:  0.23651783
p_wrong:  0.000019459
Data Source:  BioPlex
CENPK
Tbio
Novelty:  0.04316098
Score:  0.992
Data Source:  STRINGDB
Pathways (19)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Gene Ontology Terms (7)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
1
1
56.2
mean reticulocyte volume
1
1
1
44.2
vitamin measurement
1
1
1
14.2
homocysteine measurement
1
1
1
7.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
56.2
mean reticulocyte volume
1
44.2
vitamin measurement
1
14.2
homocysteine measurement
1
7.5
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
centromere protein Q
VGNC:2658
462754
Mouse
MGI:1933744
83815
Dog
centromere protein Q
VGNC:39112
474931
Horse
centromere protein Q
VGNC:16402
100068708
Cow
centromere protein Q
VGNC:27184
616874
Species
Name
OMA
EggNOG
Inparanoid
Chimp
centromere protein Q
Mouse
Dog
centromere protein Q
Horse
centromere protein Q
Cow
centromere protein Q
Publication Statistics
PubMed Score 4.23
PubMed score by year
PubTator Score 2.83
PubTator score by year