Tbio KCTD9 BTB/POZ domain-containing protein KCTD9

Protein Summary

Description

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome.

Uniprot Accession IDs

• Q7L273
• Q6NUM8
• Q9NXV4

Gene Name

• KCTD9

Ensembl ID

• ENST00000221200
• ENSP00000221200
• ENSG00000104756

Symbol

• BTBD27

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.85
kinase perturbation	0.76
histone modification site profile	0.74
protein domain	0.73
tissue sample	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.79   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 193   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.79   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 193   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0