You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ASRGL1
Isoaspartyl peptidase/L-asparaginase

Protein Classes
Protein Summary
Description
Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301776
  • ENSP00000301776
  • ENSG00000162174
  • ENST00000415229
  • ENSP00000400057

Symbol
  • ALP
  • CRASH
  • ALP
  • ALP1
  • CRASH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
disease perturbation
0.9
virus perturbation
0.88
kinase perturbation
0.81
disease
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.3   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 252   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.3   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 252   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
1
1
1
26
heel bone mineral density
1
1
1
2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
1
26
heel bone mineral density
1
2
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
asparaginase like 1
VGNC:11263
739620
Macaque
asparaginase like 1
718871
Mouse
MGI:1913764
66514
Rat
RGD:708526
246307
Dog
asparaginase like 1
VGNC:38192
483789
Species
Name
OMA
EggNOG
Inparanoid
Chimp
asparaginase like 1
Macaque
asparaginase like 1
Mouse
Rat
Dog
asparaginase like 1
Protein Structure (15 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q7L266-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 15
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Phenylalanine and tyrosine metabolism
Reactome
Phenylalanine metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amino acids and derivatives
Phenylalanine and tyrosine metabolism
Phenylalanine metabolism
Gene Ontology Terms (9)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (45)
1 – 10 of 45
STMN2
Tbio
Novelty: 0.00854367
p_int: 0.999927312
p_ni: 0.000072585
p_wrong: 1.02e-7
Data Source: BioPlex
NMI
Tbio
Novelty: 0.06987427
p_int: 0.999845756
p_ni: 0.000154238
p_wrong: 6e-9
Score: 0.485
Data Source: BioPlex,STRINGDB
MDM4
Tchem
Novelty: 0.00321558
p_int: 0.9997281
p_ni: 0.000271838
p_wrong: 6.2e-8
Score: 0.388
Data Source: BioPlex,STRINGDB
L1CAM
Tbio
Novelty: 0.00307041
Score: 0.903
Data Source: STRINGDB
GOT1
Tbio
Family: Enzyme
Novelty: 0.00448817
Score: 0.9
Data Source: STRINGDB
ASPG
Tbio
Family: Enzyme
Novelty: 0.00338263
Score: 0.762
Data Source: STRINGDB
BSDC1
Tdark
Novelty: 1.591335
Score: 0.689
Data Source: STRINGDB
CHST12
Tbio
Family: Enzyme
Novelty: 0.04560641
Score: 0.681
Data Source: STRINGDB
KIAA2013
Tdark
Novelty: 0.4705158
Score: 0.679
Data Source: STRINGDB
RCC2
Tbio
Novelty: 0.01806322
Score: 0.663
Data Source: STRINGDB
Publication Statistics
PubMed Score  42.30

PubMed score by year
PubTator Score  1701.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer