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Tbio
LRRC8D
Volume-regulated anion channel subunit LRRC8D

Protein Summary
Description
Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26530471, PubMed:26824658, PubMed:28193731). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (PubMed:24790029, PubMed:26824658, PubMed:28193731). Plays a redundant role in the efflux of amino acids, such as aspartate, in response to osmotic stress (PubMed:28193731). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24782309, PubMed:24790029, PubMed:26824658, PubMed:28193731). LRRC8A and LRRC8D are required for the uptake of the drug cisplatin (PubMed:26530471). Mediates the import of the antibiotic blasticidin-S into the cell (PubMed:24782309).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337338
  • ENSP00000338887
  • ENSG00000171492
  • ENST00000394593
  • ENSP00000378093

Symbol
  • LRRC5
  • LRRC5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
transcription factor binding site profile
0.88
transcription factor
0.84
microRNA
0.62
histone modification site profile
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.49   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 44   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.49   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 44   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (42)
LRRC8B
Tbio
Novelty:  0.16457267
p_int:  0.999999984
p_ni:  1.1e-8
p_wrong:  5e-9
Score:  0.229
Data Source:  BioPlex,STRINGDB
NKAIN1
Tdark
Family:  Enzyme
Novelty:  0.52190272
p_int:  0.999996667
p_ni:  0.000003333
Data Source:  BioPlex
HTR3A
Tclin
Family:  IC
Novelty:  0.00217443
p_int:  0.999977424
p_ni:  0.000022561
p_wrong:  1.5e-8
Data Source:  BioPlex
RXFP1
Tchem
Family:  GPCR
Novelty:  0.00580827
p_int:  0.999974079
p_ni:  0.000025916
p_wrong:  5e-9
Data Source:  BioPlex
SLC17A2
Tdark
Family:  Transporter
Novelty:  0.23941275
p_int:  0.999945476
p_ni:  0.000052175
p_wrong:  0.000002348
Score:  0.175
Data Source:  BioPlex,STRINGDB
LRRC8A
Tbio
Novelty:  0.0163093
Score:  0.929
Data Source:  Reactome,STRINGDB
GEMIN8
Tbio
Novelty:  0.19515325
Score:  0.793
Data Source:  STRINGDB
ADGRL3
Tbio
Family:  GPCR
Novelty:  0.00268343
Score:  0.685
Data Source:  STRINGDB
ADGRL2
Tbio
Family:  GPCR
Novelty:  0.00985539
Score:  0.685
Data Source:  STRINGDB
ADGRL1
Tbio
Family:  GPCR
Novelty:  0.00957739
Score:  0.685
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Miscellaneous transport and binding events (R-HSA-5223345)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Miscellaneous transport and binding events
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Miscellaneous transport and binding events
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
3
4
90.2
diastolic blood pressure
1
1
1
36.5
heel bone mineral density
1
1
1
30.2
mathematical ability
1
1
1
26.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
4
90.2
diastolic blood pressure
1
36.5
heel bone mineral density
1
30.2
mathematical ability
1
26.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
leucine rich repeat containing 8 VRAC subunit D
100423127
Mouse
MGI:1922368
231549
Rat
RGD:1309601
305131
Dog
leucine rich repeat containing 8 VRAC subunit D
VGNC:42817
490167
Horse
leucine rich repeat containing 8 VRAC subunit D
VGNC:19795
100061270
Species
Name
OMA
EggNOG
Inparanoid
Macaque
leucine rich repeat containing 8 VRAC subunit D
Mouse
Rat
Dog
leucine rich repeat containing 8 VRAC subunit D
Horse
leucine rich repeat containing 8 VRAC subunit D
Publication Statistics
PubMed Score 6.49
PubMed score by year
PubTator Score 3.78
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title