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Tbio
CYB5R4
Cytochrome b5 reductase 4

Protein Summary
Description
NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin. NCB5OR is a flavohemoprotein that contains functional domains found in both cytochrome b5 (CYB5A; MIM 613218) and CYB5 reductase (CYB5R3; MIM 613213) (Zhu et al., 1999 [PubMed 10611283]).[supplied by OMIM, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369681
  • ENSP00000358695
  • ENSG00000065615

Symbol
  • NCB5OR
  • NCB5OR
  • cb5/cb5R
  • dJ676J13.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
protein domain
0.99
molecular function
0.81
transcription factor binding site profile
0.78
kinase perturbation
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.8   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 129   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.8   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (56)
Erythrocytes take up carbon dioxide and release oxygen (R-HSA-1237044)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Erythrocytes take up carbon dioxide and release oxygen
Reactome
O2/CO2 exchange in erythrocytes
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Erythrocytes take up carbon dioxide and release oxygen
O2/CO2 exchange in erythrocytes
Transport of small molecules
Gene Ontology Terms (17)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (91)
1 – 10 of 91
HBB
Tbio
Novelty: 0.00049683
Score: 0.928
Data Source: Reactome,STRINGDB
MRAP2
Tbio
Novelty: 0.0420503
Score: 0.807
Data Source: STRINGDB
FA2H
Tbio
Family: Enzyme
Novelty: 0.00449208
Score: 0.739
Data Source: STRINGDB
PRSS35
Tbio
Family: Enzyme
Novelty: 0.28801395
Score: 0.727
Data Source: STRINGDB
DOP1A
Tdark
Novelty: 0.040097
Score: 0.726
Data Source: STRINGDB
RIPPLY2
Tdark
Novelty: 0.16163153
Score: 0.722
Data Source: STRINGDB
CFAP206
Tdark
Novelty: 1.22847252
Score: 0.719
Data Source: STRINGDB
UBE3D
Tbio
Family: Enzyme
Novelty: 0.44919491
Score: 0.719
Data Source: STRINGDB
CYB5D1
Tdark
Novelty: 1.31560651
Score: 0.711
Data Source: STRINGDB
SUOX
Tbio
Family: Enzyme
Novelty: 0.00971136
Score: 0.684
Data Source: STRINGDB
Publication Statistics
PubMed Score  19.80

PubMed score by year
PubTator Score  5.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer