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Tbio
CHST9
Carbohydrate sulfotransferase 9

Protein Classes
Protein Summary
Description
Catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Participates in biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Has a higher activity toward carbonic anhydrase VI than toward lutropin. Only active against terminal GalNAcbeta1,GalNAcbeta. Isoform 2, but not isoform 1, is active toward chondroitin. The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Sulfate groups on carbohydrates confer highly specific functions to glycoproteins, glycolipids, and proteoglycans, and are critical for cell-cell interaction, signal transduction, and embryonic development. Alternatively spliced transcript variants have been described for this gene. [ ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000580774
  • ENSP00000464655
  • ENSG00000154080
  • ENST00000581714
  • ENSP00000462852
  • ENST00000618847
  • ENSP00000480991

Symbol
  • GalNAc4ST2
  • GALNAC4ST-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.97
virus perturbation
0.79
pathway
0.65
cellular component
0.63
tissue sample
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.51   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 124   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.51   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 124   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
unipolar depression
1
1
0
3.6
74.3
1
1
0
3.6
74.3
systolic blood pressure
1
1
1
39.9
2
1
0
1
36.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
unipolar depression
0
3.6
74.3
0
3.6
74.3
systolic blood pressure
1
39.9
0
1
36.3
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
carbohydrate sulfotransferase 9
703877
Mouse
MGI:1918617
71367
Rat
RGD:1307302
291770
Dog
carbohydrate sulfotransferase 9
VGNC:49746
100688744
Cow
carbohydrate sulfotransferase 9
VGNC:27349
525909
Species
Name
OMA
EggNOG
Inparanoid
Macaque
carbohydrate sulfotransferase 9
Mouse
Rat
Dog
carbohydrate sulfotransferase 9
Cow
carbohydrate sulfotransferase 9
Pathways (8)
Chondroitin sulfate biosynthesis (R-HSA-2022870)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chondroitin sulfate biosynthesis
Reactome
Chondroitin sulfate/dermatan sulfate metabolism
Reactome
Glycosaminoglycan metabolism
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Chondroitin sulfate biosynthesis
Chondroitin sulfate/dermatan sulfate metabolism
Glycosaminoglycan metabolism
Metabolism
Metabolism of carbohydrates
Protein-Protein Interactions (30)
1 – 10 of 30
LRP6
Tbio
Novelty: 0.00305615
p_int: 0.981574933
p_ni: 0.018425067
Score: 0.222
Data Source: BioPlex,STRINGDB
LRP5
Tbio
Novelty: 0.00089807
p_int: 0.948508025
p_ni: 0.051491974
p_wrong: 1e-9
Score: 0.196
Data Source: BioPlex,STRINGDB
CANX
Tbio
Novelty: 0.00087002
p_int: 0.935658708
p_ni: 0.064341292
Score: 0.252
Data Source: BioPlex,STRINGDB
CHST8
Tbio
Family: Enzyme
Novelty: 0.03489772
Score: 0.815
Data Source: STRINGDB
CA6
Tclin
Family: Enzyme
Novelty: 0.00293722
Score: 0.801
Data Source: STRINGDB
CHST6
Tbio
Family: Enzyme
Novelty: 0.01917947
Score: 0.675
Data Source: STRINGDB
CHST1
Tbio
Family: Enzyme
Novelty: 0.05238404
Score: 0.661
Data Source: STRINGDB
LHB
Tbio
Novelty: 0.00196754
Score: 0.628
Data Source: STRINGDB
ANTXRL
Tdark
Novelty: 3.76351765
Score: 0.556
Data Source: STRINGDB
ELOA3C
Tdark
Novelty: 2.42898934
Score: 0.556
Data Source: STRINGDB
Publication Statistics
PubMed Score  5.51

PubMed score by year
PubTator Score  4.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer