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Tbio
BZW1
Basic leucine zipper and W2 domain-containing protein 1

Protein Summary
Description
Enhances histone H4 gene transcription but does not seem to bind DNA directly.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000409226
  • ENSP00000386837
  • ENSG00000082153
  • ENST00000409600
  • ENSP00000386474
  • ENST00000452790
  • ENSP00000394316

Symbol
  • BZAP45
  • KIAA0005
  • BZAP45
  • Nbla10236
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
transcription factor perturbation
0.98
disease perturbation
0.93
kinase perturbation
0.91
transcription factor binding site profile
0.86


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.01   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 80   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.01   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 80   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
1
1
1.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
1.1
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
basic leucine zipper and W2 domains 1
VGNC:107
459864
Mouse
MGI:1914132
66882
Rat
RGD:735129
363232
Dog
basic leucine zipper and W2 domains 1
VGNC:38571
478865
Horse
basic leucine zipper and W2 domains 1
VGNC:15931
100067807
Species
Name
OMA
EggNOG
Inparanoid
Chimp
basic leucine zipper and W2 domains 1
Mouse
Rat
Dog
basic leucine zipper and W2 domains 1
Horse
basic leucine zipper and W2 domains 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q7L1Q6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (4)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (60)
1 – 10 of 60
GYPB
Tbio
Novelty: 0.00442195
p_int: 0.999959239
p_ni: 0.00004076
p_wrong: 1e-9
Data Source: BioPlex
BZW2
Tbio
Novelty: 0.17006204
p_int: 0.999906101
p_ni: 0.000093899
Score: 0.826
Data Source: BioPlex,STRINGDB
RNF138
Tbio
Family: TF
Novelty: 0.07543428
p_int: 0.997585316
p_ni: 0.00241347
p_wrong: 0.000001215
Score: 0.259
Data Source: BioPlex,STRINGDB
SCCPDH
Tbio
Family: Enzyme
Novelty: 0.06603568
p_int: 0.964014582
p_ni: 0.035892008
p_wrong: 0.00009341
Score: 0.239
Data Source: BioPlex,STRINGDB
ENPP1
Tchem
Family: Enzyme
Novelty: 0.00256132
p_int: 0.961798207
p_ni: 0.038201793
Score: 0.256
Data Source: BioPlex,STRINGDB
KLRC4
Tbio
Novelty: 0.16922525
p_int: 0.881799557
p_ni: 0.118200443
Data Source: BioPlex
TMEM43
Tbio
Novelty: 0.03549545
p_int: 0.833340711
p_ni: 0.166659289
Score: 0.747
Data Source: BioPlex,STRINGDB
TRARG1
Tbio
Novelty: 0.07729433
p_int: 0.831368473
p_ni: 0.168631527
Score: 0.228
Data Source: BioPlex,STRINGDB
TMEM206
Tdark
Novelty: 0.17311172
p_int: 0.822168372
p_ni: 0.177831628
Data Source: BioPlex
CDC5L
Tbio
Family: TF
Novelty: 0.00663599
Score: 0.981
Data Source: STRINGDB
Publication Statistics
PubMed Score  10.01

PubMed score by year
PubTator Score  2.45

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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