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Tbio
SV2B
Synaptic vesicle glycoprotein 2B

Protein Summary
Description
Probably plays a role in the control of regulated secretion in neural and endocrine cells. (Microbial infection) Receptor for the C.botulinum neurotoxin type A2 (BoNT/A, botA); glycosylation is not essential but enhances the interaction (PubMed:29649119). Probably also serves as a receptor for the closely related C.botulinum neurotoxin type A1. This gene encodes a member of the synaptic vesicle proteins 2 (SV2) family and major facilitator superfamily of proteins. This protein and other members of the family are localized to synaptic vesicles and may function in the regulation of vesicle trafficking and exocytosis. Studies in mice suggest that the encoded protein may act as a protein receptor for botulinum neurotoxin E in neurons, and that this protein may be important for the integrity of the glomerular filtration barrier. This gene shows reduced expression in areas of synaptic loss in the hippocampus of human temporal lobe epilepsy patients. [provided by RefSeq, Sep 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330276
  • ENSP00000332818
  • ENSG00000185518
  • ENST00000394232
  • ENSP00000377779
  • ENST00000545111
  • ENSP00000443243
  • ENST00000557410
  • ENSP00000450992

Symbol
  • KIAA0735
  • HsT19680
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
gene perturbation
0.74
cell type or tissue
0.65
microRNA
0.65
cellular component
0.64


Related Tools
RESOLUTE
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RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.17   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 129   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.17   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
33.3
79.4
1
1
0
100
77.1
red blood cell distribution width
1
1
1
65.6
Ischemic stroke
1
1
0
14.3
28.1
1
1
0
1.1
28.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
33.3
79.4
0
100
77.1
red blood cell distribution width
1
65.6
Ischemic stroke
0
14.3
28.1
0
1.1
28.1
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
synaptic vesicle glycoprotein 2B
VGNC:13471
467765
Macaque
synaptic vesicle glycoprotein 2B
710980
Mouse
MGI:1927338
64176
Dog
synaptic vesicle glycoprotein 2B
VGNC:47004
488723
Horse
synaptic vesicle glycoprotein 2B
VGNC:23779
100070267
Species
Name
OMA
EggNOG
Inparanoid
Chimp
synaptic vesicle glycoprotein 2B
Macaque
synaptic vesicle glycoprotein 2B
Mouse
Dog
synaptic vesicle glycoprotein 2B
Horse
synaptic vesicle glycoprotein 2B
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q7L1I2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Infectious disease
Reactome
Neurotoxicity of clostridium toxins
Reactome
Toxicity of botulinum toxin type A (BoNT/A)
Reactome
Toxicity of botulinum toxin type D (BoNT/D)
Name
Explore in Pharos
Explore in Source
Disease
Infectious disease
Neurotoxicity of clostridium toxins
Toxicity of botulinum toxin type A (BoNT/A)
Toxicity of botulinum toxin type D (BoNT/D)
Gene Ontology Terms (11)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (92)
1 – 10 of 92
SYT1
Tbio
Novelty:  0.00176103
Score:  0.883
Data Source:  STRINGDB
SV2C
Tbio
Novelty:  0.03221681
Score:  0.825
Data Source:  STRINGDB
SV2A
Tclin
Novelty:  0.00127015
Score:  0.822
Data Source:  STRINGDB
GP2
Tbio
Novelty:  0.00126542
Score:  0.8
Data Source:  STRINGDB
LAMB4
Tbio
Novelty:  0.11269352
Score:  0.784
Data Source:  STRINGDB
LAMA3
Tbio
Novelty:  0.00733792
Score:  0.759
Data Source:  STRINGDB
LAMC2
Tbio
Novelty:  0.00695692
Score:  0.743
Data Source:  STRINGDB
DYNC1I1
Tbio
Novelty:  0.12175372
Score:  0.712
Data Source:  STRINGDB
LAMB1
Tbio
Novelty:  0.0104285
Score:  0.709
Data Source:  STRINGDB
MFSD11
Tdark
Novelty:  0.13167358
Score:  0.702
Data Source:  STRINGDB
Publication Statistics
PubMed Score  30.17

PubMed score by year
PubTator Score  11.47

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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