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Tbio
DPPA4
Developmental pluripotency-associated protein 4

Protein Summary
Description
May be involved in the maintenance of active epigenetic status of target genes. May inhibit differentiation of embryonic cells into a primitive ectoderm lineage. This gene encodes a nuclear factor that is involved in the maintenance of pluripotency in stem cells and essential for embryogenesis. The encoded protein has a scaffold-attachment factor A/B, acinus and PIAS (SAP) domain that binds DNA and is thought to modify chromatin. Mice with a homozygous knockout of the orthologous gene die during late embryonic development or within hours after birth. Knockout embryos are normal in size at embryonic day 18.5 but exhibit skeletal and lung tissue abnormalities. This gene, when mutated, is highly expressed in embryonal carcinomas, pluripotent germ cell tumors, and other cancers and is thought to play an important role in tumor progression. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335658
  • ENSP00000335306
  • ENSG00000121570

Symbol
  • 2410091M23Rik
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.6
PubMedID
0.55
gene perturbation
0.52
cell type or tissue
0.46
virus perturbation
0.45


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.38   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 291   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.38   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 291   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Horse
developmental pluripotency associated 4 [Source:HGNC Symbol;Acc:HGNC:19200]
Cow
developmental pluripotency associated 4
783813
Species
Name
OMA
EggNOG
Inparanoid
Horse
developmental pluripotency associated 4 [Source:HGNC Symbol;Acc:HGNC:19200]
Cow
developmental pluripotency associated 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q7L190-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Reactome
Transcriptional regulation of pluripotent stem cells
Name
Explore in Pharos
Explore in Source
Developmental Biology
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Transcriptional regulation of pluripotent stem cells
Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (71)
1 – 10 of 71
ADD2
Tbio
Family: Enzyme
Novelty: 0.01097975
p_int: 0.999998159
p_ni: 0.000001839
p_wrong: 2e-9
Score: 0.527
Data Source: BioPlex,STRINGDB
L3MBTL3
Tchem
Family: Epigenetic
Novelty: 0.04659049
p_int: 0.999225887
p_ni: 0.000005613
p_wrong: 0.0007685
Score: 0.692
Data Source: BioPlex,STRINGDB
SH3GL1
Tbio
Novelty: 0.02379336
p_int: 0.998628616
p_ni: 0.001371384
Score: 0.338
Data Source: BioPlex,STRINGDB
HAL
Tbio
Family: Enzyme
Novelty: 0.01504631
p_int: 0.997934813
p_ni: 0.002065187
Data Source: BioPlex
TIGD5
Tdark
Novelty: 1.93340494
p_int: 0.997408445
p_ni: 0.002591555
Data Source: BioPlex
SDR9C7
Tbio
Family: Enzyme
Novelty: 0.01618496
p_int: 0.996490652
p_ni: 0.003509247
p_wrong: 1.02e-7
Score: 0.198
Data Source: BioPlex,STRINGDB
SAMD1
Tdark
Novelty: 0.21956379
p_int: 0.996031595
p_ni: 0.003968405
Data Source: BioPlex
ADD1
Tbio
Family: Enzyme
Novelty: 0.0040587
p_int: 0.994730279
p_ni: 0.005269721
Score: 0.692
Data Source: BioPlex,STRINGDB
RNASE7
Tbio
Family: Enzyme
Novelty: 0.01866347
p_int: 0.992728516
p_ni: 0.007268218
p_wrong: 0.000003266
Data Source: BioPlex
SNX9
Tbio
Novelty: 0.01737783
p_int: 0.983617217
p_ni: 0.016382783
Score: 0.198
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  16.38

PubMed score by year
PubTator Score  9.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer