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Tbio
TRMT10C
tRNA methyltransferase 10 homolog C

Protein Summary
Description
Mitochondrial tRNA N(1)-methyltransferase involved in mitochondrial tRNA maturation (PubMed:18984158, PubMed:21593607, PubMed:23042678, PubMed:27132592). Component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and MRPP3, which cleaves tRNA molecules in their 5'-ends (PubMed:18984158). Together with HSD17B10/MRPP2, forms a subcomplex of the mitochondrial ribonuclease P, named MRPP1-MRPP2 subcomplex, which displays functions that are independent of the ribonuclease P activity (PubMed:23042678, PubMed:29040705). The MRPP1-MRPP2 subcomplex catalyzes the formation of N(1)-methylguanine and N(1)-methyladenine at position 9 (m1G9 and m1A9, respectively) in tRNAs; TRMT10C/MRPP1 acting as the catalytic N(1)-methyltransferase subunit (PubMed:23042678). The MRPP1-MRPP2 subcomplex also acts as a tRNA maturation platform: following 5'-end cleavage by the mitochondrial ribonuclease P complex, the MRPP1-MRPP2 subcomplex enhances the efficiency of 3'-processing c ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309922
  • ENSP00000312356
  • ENSG00000174173

Symbol
  • MRPP1
  • RG9MTD1
  • HNYA
  • MRPP1
  • COXPD30
  • RG9MTD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
histone modification site profile
0.8
transcription factor binding site profile
0.65
tissue sample
0.62
small molecule perturbation
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.98   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 61   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.98   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 61   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
1
2
73.5
eosinophil percentage of leukocytes
1
1
1
40
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
73.5
eosinophil percentage of leukocytes
1
40
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tRNA methyltransferase 10C, mitochondrial RNase P subunit
VGNC:10475
740267
Macaque
tRNA methyltransferase 10C, mitochondrial RNase P subunit
702107
Mouse
MGI:1196261
52575
Rat
RGD:1306333
304012
Dog
tRNA methyltransferase 10C, mitochondrial RNase P subunit
VGNC:47853
478545
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tRNA methyltransferase 10C, mitochondrial RNase P subunit
Macaque
tRNA methyltransferase 10C, mitochondrial RNase P subunit
Mouse
Rat
Dog
tRNA methyltransferase 10C, mitochondrial RNase P subunit
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q7L0Y3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
rRNA processing
Reactome
rRNA processing in the mitochondrion
Reactome
tRNA modification in the mitochondrion
Reactome
tRNA processing
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
rRNA processing
rRNA processing in the mitochondrion
tRNA modification in the mitochondrion
tRNA processing
Gene Ontology Terms (17)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (115)
1 – 10 of 115
VWA5A
Tbio
Novelty: 0.0802354
p_int: 0.969504896
p_ni: 0.030495104
Score: 0.179
Data Source: BioPlex,STRINGDB
ELAC2
Tbio
Family: Enzyme
Novelty: 0.01234318
p_int: 0.937680725
p_ni: 0.062319275
Score: 0.924
Data Source: BioPlex,STRINGDB
TRNT1
Tbio
Family: Enzyme
Novelty: 0.00509556
p_int: 0.935746155
p_ni: 0.064253845
Score: 0.67
Data Source: BioPlex,STRINGDB
ZZEF1
Tdark
Novelty: 0.33216648
p_int: 0.872679315
p_ni: 0.127320433
p_wrong: 2.51e-7
Score: 0.249
Data Source: BioPlex,STRINGDB
HECTD3
Tdark
Family: Enzyme
Novelty: 2.20874654
p_int: 0.827613431
p_ni: 0.172386569
Score: 0.219
Data Source: BioPlex,STRINGDB
HSD17B10
Tchem
Family: Enzyme
Novelty: 0.00486582
p_int: 0.811403461
p_ni: 0.188596539
Score: 0.994
Data Source: BioPlex,Reactome,STRINGDB
KIAA0391
Tbio
Family: Enzyme
Novelty: 0.02276396
Score: 0.994
Data Source: Reactome,STRINGDB
TRMT5
Tbio
Family: Enzyme
Novelty: 0.02509765
Score: 0.801
Data Source: STRINGDB
POP4
Tbio
Family: Enzyme
Novelty: 0.01072287
Score: 0.801
Data Source: STRINGDB
POP1
Tbio
Family: Enzyme
Novelty: 2.92497626
Score: 0.8
Data Source: STRINGDB
Publication Statistics
PubMed Score  12.98

PubMed score by year
PubTator Score  7.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer