Tbio TRIL TLR4 interactor with leucine rich repeats

Protein Summary

Description

Component of the TLR4 signaling complex. Mediate the innate immune response to bacterial lipopolysaccharide (LPS) leading to cytokine secretion. TRIL is a component of the TLR4 (MIM 603030) complex and is induced in a number of cell types by lipopolysaccharide (LPS) (Carpenter et al., 2009 [PubMed 19710467]).[supplied by OMIM, Apr 2010]

Uniprot Accession IDs

• Q7L0X0
• A4D1A6
• O75139

Gene Name

• TRIL

Ensembl ID

• ENST00000539664
• ENSP00000479256
• ENSG00000255690

Symbol

• KIAA0644

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.75
PubMedID	0.71
transcription factor binding site profile	0.64
tissue sample	0.6
protein domain	0.58

Protein Classes

PANTHER Classes

Protein / Receptor / Tlr4 Interactor With Leucine Rich Repeats

Protein / Extracellular Matrix Protein / Tlr4 Interactor With Leucine Rich Repeats

DTO Classes

Protein / Receptor / Tlr4 Interactor With Leucine Rich Repeats

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.2   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 23   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.2   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 23   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0