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Tbio
TRIL
TLR4 interactor with leucine rich repeats

Protein Classes
Protein Summary
Description
Component of the TLR4 signaling complex. Mediate the innate immune response to bacterial lipopolysaccharide (LPS) leading to cytokine secretion. TRIL is a component of the TLR4 (MIM 603030) complex and is induced in a number of cell types by lipopolysaccharide (LPS) (Carpenter et al., 2009 [PubMed 19710467]).[supplied by OMIM, Apr 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000539664
  • ENSP00000479256
  • ENSG00000255690

Symbol
  • KIAA0644
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.75
PubMedID
0.71
transcription factor binding site profile
0.64
tissue sample
0.6
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.65   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 23   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.65   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 23   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (36)
1 – 10 of 36
TLR4
Tchem
Novelty: 0.00013074
Score: 0.939
Data Source: STRINGDB
LY96
Tchem
Novelty: 0.00114737
Score: 0.921
Data Source: STRINGDB
CD14
Tbio
Novelty: 0.01019035
Score: 0.902
Data Source: STRINGDB
HSPD1
Tbio
Novelty: 0.00026641
Score: 0.73
Data Source: STRINGDB
ADGRL2
Tbio
Family: GPCR
Novelty: 0.01111728
Score: 0.685
Data Source: STRINGDB
ADGRL1
Tbio
Family: GPCR
Novelty: 0.01343585
Score: 0.685
Data Source: STRINGDB
ADGRL3
Tbio
Family: GPCR
Novelty: 0.00182297
Score: 0.685
Data Source: STRINGDB
TRIR
Tdark
Novelty: 0.00683605
Score: 0.638
Data Source: STRINGDB
ACD
Tbio
Novelty: 0.00356212
Score: 0.585
Data Source: STRINGDB
TRAF3IP3
Tbio
Novelty: 0.22909091
Score: 0.533
Data Source: STRINGDB
Publication Statistics
PubMed Score  43.65

PubMed score by year
PubTator Score  12.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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