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Tbio
RHOU
Rho-related GTP-binding protein RhoU

Protein Summary
Description
Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP-bound. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. This gene encodes a member of the Rho family of GTPases. This protein can activate PAK1 and JNK1, and can induce filopodium formation and stress fiber dissolution. It may also mediate the effects of WNT1 signaling in the regulation of cell morphology, cytoskeletal organization, and cell proliferation. A non-coding transcript variant of this gene results from naturally occurring read-through transcription between this locus and the neighboring DUSP5P (dual specificity phosphatase 5 pseudogene) locus.[provided by RefSeq, Mar 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366691
  • ENSP00000355652
  • ENSG00000116574
  • ENST00000646945
  • ENSP00000494673
  • ENSG00000284984

Symbol
  • ARHU
  • CDC42L1
  • G28K
  • WRCH1
  • ARHU
  • G28K
  • WRCH1
  • hG28K
  • CDC42L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
molecular function
0.94
PubMedID
0.82
gene perturbation
0.74
small molecule perturbation
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.05   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 136   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.05   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 136   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (234)
1 – 10 of 234
IFNGR1
Tbio
Novelty:  0.00417244
p_int:  0.945747576
p_ni:  0.000009858
p_wrong:  0.054242566
Score:  0.195
Data Source:  BioPlex,STRINGDB
IP6K2
Tbio
Family:  Kinase
Novelty:  0.05004446
p_int:  0.84573363
p_ni:  0.000004364
p_wrong:  0.154262007
Score:  0.717
Data Source:  BioPlex,STRINGDB
ARHGDIA
Tchem
Novelty:  0.001991
Score:  0.966
Data Source:  STRINGDB
MCF2
Tbio
Novelty:  0.00345951
Score:  0.966
Data Source:  STRINGDB
ITSN1
Tbio
Novelty:  0.01327346
Score:  0.966
Data Source:  STRINGDB
VAV1
Tchem
Novelty:  0.00180518
Score:  0.964
Data Source:  STRINGDB
ARHGAP35
Tbio
Family:  Enzyme
Novelty:  0.00970784
Score:  0.961
Data Source:  STRINGDB
TIAM1
Tbio
Novelty:  0.00431726
Score:  0.961
Data Source:  STRINGDB
VAV2
Tbio
Novelty:  0.01062502
Score:  0.958
Data Source:  STRINGDB
VAV3
Tbio
Novelty:  0.010944
Score:  0.957
Data Source:  STRINGDB
Pathways (9)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-4 and Interleukin-13 signaling
Reactome
Rho GTPase cycle
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-4 and Interleukin-13 signaling
Rho GTPase cycle
Signal Transduction
Gene Ontology Terms (26)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.2
44.2
1
1
0
1.1
12.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
44.2
0
1.1
12.7
Find similar targets by:
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ras homolog family member U
695385
Mouse
MGI:1916831
69581
Dog
ras homolog family member U
VGNC:45565
100856047
Horse
ras homolog family member U [Source:HGNC Symbol;Acc:HGNC:17794]
Cow
ras homolog family member U
VGNC:33955
781044
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ras homolog family member U
Mouse
Dog
ras homolog family member U
Horse
ras homolog family member U [Source:HGNC Symbol;Acc:HGNC:17794]
Cow
ras homolog family member U
Publication Statistics
PubMed Score 59.05
PubMed score by year
PubTator Score 17.35
PubTator score by year