Tbio RHOU Rho-related GTP-binding protein RhoU

Protein Summary

Description

Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP-bound. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. This gene encodes a member of the Rho family of GTPases. This protein can activate PAK1 and JNK1, and can induce filopodium formation and stress fiber dissolution. It may also mediate the effects of WNT1 signaling in the regulation of cell morphology, cytoskeletal organization, and cell proliferation. A non-coding transcript variant of this gene results from naturally occurring read-through transcription between this locus and the neighboring DUSP5P (dual specificity phosphatase 5 pseudogene) locus.[provided by RefSeq, Mar 2011]

Uniprot Accession IDs

• Q7L0Q8
• B1AKN1
• Q59FE9
• Q8TDQ2

Gene Name

• RHOU

Ensembl ID

• ENST00000366691
• ENSP00000355652
• ENSG00000116574
• ENST00000646945
• ENSP00000494673
• ENSG00000284984

Symbol

• ARHU
• CDC42L1
• G28K
• WRCH1
• ARHU
• G28K
• WRCH1
• hG28K
• CDC42L1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.99
molecular function	0.94
PubMedID	0.82
gene perturbation	0.74
small molecule perturbation	0.73

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein / Small Gtpase / Rho-related Gtp-binding Protein Rhou

DTO Classes

Protein / Enzyme Modulator / G-protein / Small Gtpase / Rho-related Gtp-binding Protein Rhou

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.04   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 136   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.04   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 136   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0