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Tchem
MARK2
Serine/threonine-protein kinase MARK2

Protein Summary
Description
Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylase ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000350490
  • ENSP00000294247
  • ENSG00000072518
  • ENST00000361128
  • ENSP00000355091
  • ENST00000402010
  • ENSP00000385751
  • ENST00000408948
  • ENSP00000386128
  • ENST00000508192
  • ENSP00000425765
  • ENST00000509502
  • ENSP00000423974
  • ENST00000513765
  • ENSP00000421075

Symbol
  • EMK1
  • EMK1
  • EMK-1
  • PAR-1
  • Par1b
  • Par-1b
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
interacting protein
1
molecular function
1
protein domain
0.97
kinase
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 185   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 418   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 185   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 418   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1
60.7
unipolar depression
1
1
0
1
60.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1
60.7
unipolar depression
0
1
60.7
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (16)
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: netpath
TNFalpha
PathwayCommons: netpath
Wnt
PathwayCommons: pid
Notch signaling pathway
PathwayCommons: pid
LKB1 signaling events
Name
Explore in Pharos
Explore in Source
TNFalpha
Wnt
Notch signaling pathway
LKB1 signaling events
Gene Ontology Terms (38)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
ARUK-UCL
Traceable Author Statement (TAS)
ParkinsonsUK-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (93)
1 – 10 of 93
COL4A3BP
Tbio
Novelty: 0.00357203
p_int: 0.999999982
p_ni: 1.8e-8
Score: 0.194
Data Source: BioPlex,STRINGDB
FUCA1
Tchem
Family: Enzyme
Novelty: 0.00961721
p_int: 0.999999757
p_ni: 2.42e-7
Score: 0.552
Data Source: BioPlex,STRINGDB
TMCC2
Tdark
Novelty: 0.21581357
p_int: 0.999923553
p_ni: 0.000076446
Score: 0.157
Data Source: BioPlex,STRINGDB
NRROS
Tbio
Novelty: 0.08976002
p_int: 0.999843328
p_ni: 0.000156672
Score: 0.189
Data Source: BioPlex,STRINGDB
GPSM3
Tbio
Novelty: 0.01632501
p_int: 0.995567803
p_ni: 0.00443209
p_wrong: 1.07e-7
Data Source: BioPlex
NUAK2
Tchem
Family: Kinase
Novelty: 0.02463599
p_int: 0.97877846
p_ni: 0.021221525
p_wrong: 1.5e-8
Score: 0.274
Data Source: BioPlex,STRINGDB
MACC1
Tbio
Novelty: 0.00737376
p_int: 0.974106293
p_ni: 0.025893687
p_wrong: 2e-8
Data Source: BioPlex
SIX2
Tbio
Family: TF
Novelty: 0.01046481
p_int: 0.970222811
p_ni: 0.029776184
p_wrong: 0.000001006
Score: 0.185
Data Source: BioPlex,STRINGDB
MANSC1
Tdark
Novelty: 0.91681036
p_int: 0.939541738
p_ni: 0.060446066
p_wrong: 0.000012195
Data Source: BioPlex
CDH19
Tbio
Novelty: 0.0759041
p_int: 0.833332592
p_ni: 0.166619198
p_wrong: 0.00004821
Score: 0.161
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  185.00

PubMed score by year
PubTator Score  196.78

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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