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Tchem
MARK2
Serine/threonine-protein kinase MARK2

Protein Summary
Description
Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylase ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000350490
  • ENSP00000294247
  • ENSG00000072518
  • ENST00000361128
  • ENSP00000355091
  • ENST00000402010
  • ENSP00000385751
  • ENST00000408948
  • ENSP00000386128
  • ENST00000508192
  • ENSP00000425765
  • ENST00000509502
  • ENSP00000423974
  • ENST00000513765
  • ENSP00000421075

Symbol
  • EMK1
  • EMK1
  • EMK-1
  • PAR-1
  • Par1b
  • Par-1b
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
interacting protein
1
molecular function
1
protein domain
0.97
kinase
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 185.8   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 418   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 185.8   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 418   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (93)
COL4A3BP
Tbio
Novelty:  0.00357203
p_int:  0.999999982
p_ni:  1.8e-8
Score:  0.194
Data Source:  BioPlex,STRINGDB
FUCA1
Tchem
Family:  Enzyme
Novelty:  0.00961721
p_int:  0.999999757
p_ni:  2.42e-7
Score:  0.552
Data Source:  BioPlex,STRINGDB
TMCC2
Tdark
Novelty:  0.21581357
p_int:  0.999923553
p_ni:  0.000076446
Score:  0.157
Data Source:  BioPlex,STRINGDB
NRROS
Tbio
Novelty:  0.08976002
p_int:  0.999843328
p_ni:  0.000156672
Score:  0.189
Data Source:  BioPlex,STRINGDB
GPSM3
Tbio
Novelty:  0.01632501
p_int:  0.995567803
p_ni:  0.00443209
p_wrong:  1.07e-7
Data Source:  BioPlex
NUAK2
Tchem
Family:  Kinase
Novelty:  0.02463599
p_int:  0.97877846
p_ni:  0.021221525
p_wrong:  1.5e-8
Score:  0.274
Data Source:  BioPlex,STRINGDB
MACC1
Tbio
Novelty:  0.00737376
p_int:  0.974106293
p_ni:  0.025893687
p_wrong:  2e-8
Data Source:  BioPlex
SIX2
Tbio
Family:  TF
Novelty:  0.01046481
p_int:  0.970222811
p_ni:  0.029776184
p_wrong:  0.000001006
Score:  0.185
Data Source:  BioPlex,STRINGDB
MANSC1
Tdark
Novelty:  0.91681036
p_int:  0.939541738
p_ni:  0.060446066
p_wrong:  0.000012195
Data Source:  BioPlex
CDH19
Tbio
Novelty:  0.0759041
p_int:  0.833332592
p_ni:  0.166619198
p_wrong:  0.00004821
Score:  0.161
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: netpath
TNFalpha
PathwayCommons: netpath
Wnt
PathwayCommons: pid
Notch signaling pathway
PathwayCommons: pid
LKB1 signaling events
Name
Explore in Pharos
Explore in Source
TNFalpha
Wnt
Notch signaling pathway
LKB1 signaling events
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (38)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
ARUK-UCL
Traceable Author Statement (TAS)
ParkinsonsUK-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
1
1
2
42.3
low density lipoprotein cholesterol measurement
2
2
2
34.7
systolic blood pressure
1
1
1
28.9
1
1
0
1
21.5
1
1
0
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
2
42.3
low density lipoprotein cholesterol measurement
2
34.7
systolic blood pressure
1
28.9
0
1
21.5
0
1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
microtubule affinity regulating kinase 2
718065
Mouse
MGI:99638
13728
Rat
RGD:708483
60328
Dog
microtubule affinity regulating kinase 2
VGNC:43024
483769
Horse
microtubule affinity regulating kinase 2
VGNC:19984
100049882
Species
Name
OMA
EggNOG
Inparanoid
Macaque
microtubule affinity regulating kinase 2
Mouse
Rat
Dog
microtubule affinity regulating kinase 2
Horse
microtubule affinity regulating kinase 2
Publication Statistics
PubMed Score 185.80
PubMed score by year
PubTator Score 196.78
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title