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Tbio
SUPT6H
Transcription elongation factor SPT6

Protein Summary
Description
Transcription elongation factor which binds histone H3 and plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deamina ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314616
  • ENSP00000319104
  • ENSG00000109111
  • ENST00000347486
  • ENSP00000338143

Symbol
  • KIAA0162
  • SPT6H
  • SPT6
  • SPT6H
  • emb-5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
biological process
0.92
histone modification site profile
0.88
ligand (protein) perturbation
0.83
transcription factor perturbation
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.75   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 140   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.75   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
83.2
reticulocyte count
2
2
2
83
reticulocyte measurement
1
1
1
58.4
mean platelet volume
1
1
1
44.2
insomnia measurement
1
2
0
1.1
37.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
83.2
reticulocyte count
2
83
reticulocyte measurement
1
58.4
mean platelet volume
1
44.2
insomnia measurement
0
1.1
37.3
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SPT6 homolog, histone chaperone
VGNC:9670
454529
Macaque
SPT6 homolog, histone chaperone
716230
Mouse
MGI:107726
20926
Rat
RGD:1309290
303281
Dog
SPT6 homolog, histone chaperone
VGNC:49096
480627
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SPT6 homolog, histone chaperone
Macaque
SPT6 homolog, histone chaperone
Mouse
Rat
Dog
SPT6 homolog, histone chaperone
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q7KZ85-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Formation of RNA Pol II elongation complex (R-HSA-112382)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Formation of RNA Pol II elongation complex
Reactome
Gene expression (Transcription)
Reactome
RNA Polymerase II Pre-transcription Events
Reactome
RNA Polymerase II Transcription
Reactome
RNA Polymerase II Transcription Elongation
Name
Explore in Pharos
Explore in Source
Formation of RNA Pol II elongation complex
Gene expression (Transcription)
RNA Polymerase II Pre-transcription Events
RNA Polymerase II Transcription
RNA Polymerase II Transcription Elongation
Gene Ontology Terms (27)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (296)
1 – 10 of 296
POLR2J
Tbio
Family:  Enzyme
Novelty:  0.02344868
p_int:  0.999948659
p_ni:  0.000051341
Score:  0.909
Data Source:  BioPlex,STRINGDB
LMO2
Tbio
Novelty:  0.0038279
p_int:  0.999806101
p_ni:  0.000193899
Score:  0.328
Data Source:  BioPlex,STRINGDB
POLR2M
Tbio
Family:  Enzyme
Novelty:  0.11413088
p_int:  0.999404046
p_ni:  0.000595954
Score:  0.587
Data Source:  BioPlex,STRINGDB
PVRIG
Tbio
Novelty:  0.28920924
p_int:  0.998933918
p_ni:  0.001066082
Score:  0.183
Data Source:  BioPlex,STRINGDB
PIN1
Tchem
Family:  Enzyme
Novelty:  0.00957198
p_int:  0.998828692
p_ni:  0.001171308
Score:  0.376
Data Source:  BioPlex,STRINGDB
TTC29
Tdark
Novelty:  0.1887357
p_int:  0.99822343
p_ni:  0.00177657
Data Source:  BioPlex
PI15
Tbio
Family:  Enzyme
Novelty:  0.02244161
p_int:  0.997827041
p_ni:  0.002172959
Data Source:  BioPlex
TBC1D22A
Tbio
Novelty:  0.46374046
p_int:  0.996525824
p_ni:  0.003474176
Data Source:  BioPlex
HIST1H3A
Tbio
Novelty:  0.00991842
p_int:  0.995818297
p_ni:  0.004181703
Score:  0.41
Data Source:  BioPlex,STRINGDB
RPRD1B
Tbio
Novelty:  0.0444394
p_int:  0.992436798
p_ni:  0.007563202
Score:  0.789
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  104.75

PubMed score by year
PubTator Score  26.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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