Tbio SUPT6H Transcription elongation factor SPT6

Protein Summary

Description

Transcription elongation factor which binds histone H3 and plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deaminase (AICDA) target loci. Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A.

Uniprot Accession IDs

• Q7KZ85
• A7E2B4
• Q15737
• Q6GMQ4
• Q7KYW9
• Q7LDK4
• Q8N526
• Q92775
• Q96AH3
• Q9BTH9
• Q9BTI2
• hSPT6

Gene Name

• SUPT6H

Ensembl ID

• ENST00000314616
• ENSP00000319104
• ENSG00000109111
• ENST00000347486
• ENSP00000338143

Symbol

• KIAA0162
• SPT6H
• SPT6
• SPT6H
• emb-5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
biological process	0.92
histone modification site profile	0.88
ligand (protein) perturbation	0.83
transcription factor perturbation	0.8

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Elongation Factor Spt6

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Transcription Elongation Factor Spt6

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Transcription Elongation Factor Spt6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 116.5   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 140   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 116.5   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0