Tdark KNDC1 Kinase non-catalytic C-lobe domain-containing protein 1

Protein Summary

Description

RAS-Guanine nucleotide exchange factor (GEF) that controls the negative regulation of neuronal dendrite growth by mediating a signaling pathway linking RAS and MAP2 (By similarity). May be involved in cellular senescence (PubMed:24788352). The protein encoded by this gene is a Ras guanine nucleotide exchange factor that appears to negatively regulate dendritic growth in the brain. Knockdown of this gene in senescent umbilical vein endothelial cells partially reversed the senescence, showing that this gene could potentially be targeted by anti-aging therapies. [provided by RefSeq, Dec 2016]

Uniprot Accession IDs

• Q76NI1
• B0QZC5
• Q5T233
• Q6ZNH8
• Q8TEE5
• Q96LV7
• Q9C095
• KIND domain-containing protein 1

Gene Name

• KNDC1

Ensembl ID

• ENST00000304613
• ENSP00000304437
• ENSG00000171798
• ENST00000368571
• ENSP00000357560

Symbol

• C10orf23
• KIAA1768
• RASGEF2
• VKIND
• v-KIND
• RASGEF2
• C10orf23
• Very-KIND
• bB439H18.3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.85
kinase perturbation	0.84
transcription factor	0.64
PubMedID	0.58
biological process	0.52

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein Modulator / Guanyl-nucleotide Exchange Factor / Kinase Non-catalytic C-lobe Domain-containing Protein 1

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Guanyl-nucleotide Exchange Factor / Protein Very Kind

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.08   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 45   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.08   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 45   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0