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Tdark
KNDC1
Kinase non-catalytic C-lobe domain-containing protein 1

Protein Summary
Description
RAS-Guanine nucleotide exchange factor (GEF) that controls the negative regulation of neuronal dendrite growth by mediating a signaling pathway linking RAS and MAP2 (By similarity). May be involved in cellular senescence (PubMed:24788352). The protein encoded by this gene is a Ras guanine nucleotide exchange factor that appears to negatively regulate dendritic growth in the brain. Knockdown of this gene in senescent umbilical vein endothelial cells partially reversed the senescence, showing that this gene could potentially be targeted by anti-aging therapies. [provided by RefSeq, Dec 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304613
  • ENSP00000304437
  • ENSG00000171798
  • ENST00000368571
  • ENSP00000357560

Symbol
  • C10orf23
  • KIAA1768
  • RASGEF2
  • VKIND
  • v-KIND
  • RASGEF2
  • C10orf23
  • Very-KIND
  • bB439H18.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
kinase perturbation
0.84
transcription factor
0.64
PubMedID
0.58
biological process
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.08   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 45   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.08   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 45   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (71)
1 – 10 of 71
ZNF511
Tdark
Novelty:  1.07235474
Score:  0.832
Data Source:  STRINGDB
ADGRA1
Tbio
Family:  GPCR
Novelty:  0.24926468
Score:  0.77
Data Source:  STRINGDB
RAPGEFL1
Tdark
Novelty:  1.01382041
Score:  0.754
Data Source:  STRINGDB
ITM2C
Tbio
Novelty:  0.10829732
Score:  0.735
Data Source:  STRINGDB
ZSCAN29
Tdark
Family:  TF
Novelty:  1.70466621
Score:  0.734
Data Source:  STRINGDB
ELMO1
Tbio
Novelty:  0.01598587
Score:  0.725
Data Source:  STRINGDB
DOCK1
Tbio
Novelty:  0.00867391
Score:  0.725
Data Source:  STRINGDB
ZSCAN20
Tdark
Family:  TF
Novelty:  0.37441538
Score:  0.723
Data Source:  STRINGDB
C9orf72
Tbio
Novelty:  0.00096553
Score:  0.72
Data Source:  STRINGDB
RGP1
Tbio
Novelty:  4
Score:  0.72
Data Source:  STRINGDB
Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
38.8
testosterone measurement
1
1
1
28.1
multisite chronic pain
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
38.8
testosterone measurement
1
28.1
multisite chronic pain
1
15.8
Find similar targets by:
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kinase non-catalytic C-lobe domain containing 1
100611005
Macaque
kinase non-catalytic C-lobe domain containing 1
719767
Mouse
MGI:1923734
76484
Rat
RGD:1565261
361672
Horse
kinase non-catalytic C-lobe domain containing 1 [Source:HGNC Symbol;Acc:HGNC:29374]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kinase non-catalytic C-lobe domain containing 1
Macaque
kinase non-catalytic C-lobe domain containing 1
Mouse
Rat
Horse
kinase non-catalytic C-lobe domain containing 1 [Source:HGNC Symbol;Acc:HGNC:29374]
Publication Statistics
PubMed Score 9.08
PubMed score by year
PubTator Score 2.28
PubTator score by year