Tbio HECW1 E3 ubiquitin-protein ligase HECW1

Protein Summary

Description

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS.

Uniprot Accession IDs

• Q76N89
• A7E2X0
• A8MYS3
• B4DH42
• O15036
• Q9HCC7

Gene Name

• HECW1

Ensembl ID

• ENST00000395891
• ENSP00000379228
• ENSG00000002746
• ENST00000453890
• ENSP00000407774

Symbol

• KIAA0322
• NEDL1
• NEDL1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
phenotype	0.73
microRNA	0.61
tissue sample	0.61
trait	0.61
cell type or tissue	0.59

Protein Classes

PANTHER Classes

Protein / Ligase / Ubiquitin-protein Ligase / E3 Ubiquitin-protein Ligase Hecw1

DTO Classes

Protein / Enzyme / Ligase / Ubiquitin-protein Ligase / E3 Ubiquitin-protein Ligase Hecw1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.37   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 42   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.37   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 42   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0