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Tbio
HECW1
E3 ubiquitin-protein ligase HECW1

Protein Summary
Description
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000395891
  • ENSP00000379228
  • ENSG00000002746
  • ENST00000453890
  • ENSP00000407774

Symbol
  • KIAA0322
  • NEDL1
  • NEDL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
0.73
microRNA
0.61
tissue sample
0.61
trait
0.61
cell type or tissue
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.05   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 42   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.05   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 42   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
70.2
mean corpuscular volume
1
1
1
62.5
mean corpuscular hemoglobin concentration
1
1
1
51.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
70.2
mean corpuscular volume
1
62.5
mean corpuscular hemoglobin concentration
1
51.4
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
VGNC:7391
463367
Macaque
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
701331
Mouse
MGI:2444115
94253
Rat
RGD:1561038
291209
Dog
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
VGNC:41645
475868
Species
Name
OMA
EggNOG
Inparanoid
Chimp
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
Macaque
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
Mouse
Rat
Dog
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q76N89-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Degradation of DVL (R-HSA-4641258)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Degradation of DVL
Reactome
Signal Transduction
Reactome
Signaling by WNT
Reactome
TCF dependent signaling in response to WNT
Name
Explore in Pharos
Explore in Source
Degradation of DVL
Signal Transduction
Signaling by WNT
TCF dependent signaling in response to WNT
Gene Ontology Terms (11)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (95)
1 – 10 of 95
FAM189B
Tbio
Novelty:  0.21064304
p_int:  0.999999953
p_ni:  1.2e-8
p_wrong:  3.4e-8
Score:  0.173
Data Source:  BioPlex,STRINGDB
LDLRAD4
Tbio
Novelty:  0.04881486
p_int:  0.999997184
p_ni:  0.00000159
p_wrong:  0.000001226
Score:  0.216
Data Source:  BioPlex,STRINGDB
DVL1
Tchem
Novelty:  0.00356876
Score:  0.965
Data Source:  Reactome,STRINGDB
UBC
Tbio
Novelty:  0.00204643
Score:  0.948
Data Source:  STRINGDB
RPS27A
Tbio
Novelty:  0.00658124
Score:  0.939
Data Source:  STRINGDB
UBA52
Tbio
Novelty:  0.01637744
Score:  0.932
Data Source:  STRINGDB
UBB
Tbio
Novelty:  0.00661254
Score:  0.93
Data Source:  STRINGDB
PSMB4
Tbio
Family:  Enzyme
Novelty:  0.0376233
Score:  0.923
Data Source:  STRINGDB
PSMD4
Tbio
Family:  Enzyme
Novelty:  0.00614538
Score:  0.921
Data Source:  STRINGDB
PSMD1
Tbio
Family:  Enzyme
Novelty:  0.02168311
Score:  0.913
Data Source:  STRINGDB
Publication Statistics
PubMed Score  9.05

PubMed score by year
PubTator Score  4.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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