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Tchem
ERN2
Serine/threonine-protein kinase/endoribonuclease IRE2

Protein Summary
Description
Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256797
  • ENSP00000256797
  • ENSG00000134398

Symbol
  • IRE2
  • IRE1b
  • IRE2p
  • hIRE2p
  • IRE1-BETA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
protein domain
0.97
biological process
0.81
small molecule perturbation
0.64
cell type or tissue
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.33   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 197   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.33   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 197   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0