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Tbio
ASXL2
Putative Polycomb group protein ASXL2

Protein Summary
Description
Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3. This gene encodes a member of a family of epigenetic regulators that bind various histone-modifying enzymes and are involved in the assembly of transcription factors at specific genomic loci. Naturally occurring mutatio ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000404843
  • ENSP00000383920
  • ENSG00000143970
  • ENST00000435504
  • ENSP00000391447

Symbol
  • ASXH2
  • KIAA1685
  • ASXH2
  • SHAPNS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
biological process
0.93
transcription factor binding site profile
0.93
histone modification site profile
0.83
microRNA
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.86   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 53   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.86   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 53   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
3
3
92.5
reticulocyte count
2
1
2
79.6
IGF-1 measurement
1
2
2
76.7
2
2
0
1.1
72.8
hemoglobin measurement
2
2
2
71.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
92.5
reticulocyte count
2
79.6
IGF-1 measurement
2
76.7
0
1.1
72.8
hemoglobin measurement
2
71.6
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
additional sex combs like 2, transcriptional regulator
VGNC:174
459077
Macaque
additional sex combs like 2, transcriptional regulator
695057
Mouse
MGI:1922552
75302
Rat
RGD:1304710
313922
Dog
ASXL transcriptional regulator 2
VGNC:38197
100684260
Species
Name
OMA
EggNOG
Inparanoid
Chimp
additional sex combs like 2, transcriptional regulator
Macaque
additional sex combs like 2, transcriptional regulator
Mouse
Rat
Dog
ASXL transcriptional regulator 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q76L83-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
UCH proteinases
Name
Explore in Pharos
Explore in Source
Deubiquitination
Metabolism of proteins
Post-translational protein modification
UCH proteinases
Protein-Protein Interactions (66)
1 – 10 of 66
MBD5
Tbio
Family:  Epigenetic
Novelty:  0.03015349
p_int:  0.999999997
p_ni:  3e-9
Score:  0.953
Data Source:  BioPlex,STRINGDB
KDM1B
Tbio
Family:  Epigenetic
Novelty:  0.02174039
p_int:  0.999999969
p_ni:  2.9e-8
p_wrong:  1e-9
Score:  0.952
Data Source:  BioPlex,STRINGDB
BAP1
Tbio
Family:  Enzyme
Novelty:  0.00501435
p_int:  0.999999887
p_ni:  1.13e-7
Score:  0.983
Data Source:  BioPlex,Reactome,STRINGDB
ABLIM2
Tdark
Novelty:  0.23629309
p_int:  0.999813057
p_ni:  0.00011261
p_wrong:  0.000074332
Data Source:  BioPlex
MBD6
Tbio
Novelty:  0.15967769
p_int:  0.999187301
p_wrong:  0.000812699
Score:  0.98
Data Source:  BioPlex,STRINGDB
FOXK1
Tbio
Family:  TF
Novelty:  0.01321144
p_int:  0.801499359
p_ni:  0.198500641
Score:  0.969
Data Source:  BioPlex,Reactome,STRINGDB
FOXK2
Tbio
Family:  TF
Novelty:  0.01420141
Score:  0.971
Data Source:  Reactome,STRINGDB
HCFC1
Tbio
Novelty:  0.00440762
Score:  0.967
Data Source:  Reactome,STRINGDB
OGT
Tchem
Family:  Enzyme
Novelty:  0.00290822
Score:  0.959
Data Source:  Reactome,STRINGDB
UBC
Tbio
Novelty:  0.00204643
Score:  0.934
Data Source:  STRINGDB
Publication Statistics
PubMed Score  30.86

PubMed score by year
PubTator Score  17.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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