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Tbio
SLC35D2
UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter

Protein Summary
Description
Antiporter transporting nucleotide sugars such as UDP-N-acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc) and GDP-mannose (GDP-Man) pooled in the cytosol into the lumen of the Golgi in exchange for the corresponding nucleosides monophosphates (UMP for UDP-sugars and GMP for GDP-sugars). May take part in heparan sulfate synthesis by supplying UDP-Glc-NAc, the donor substrate, and thus be involved in growth factor signaling. Nucleotide sugars, which are synthesized in the cytosol or the nucleus, are high-energy donor substrates for glycosyltransferases located in the lumen of the endoplasmic reticulum and Golgi apparatus. Translocation of nucleotide sugars from the cytosol into the lumen compartment is mediated by specific nucleotide sugar transporters, such as SLC35D2 (Suda et al., 2004 [PubMed 15082721]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253270
  • ENSP00000253270
  • ENSG00000130958
  • ENST00000375259
  • ENSP00000364408

Symbol
  • HFRC
  • UGTREL8
  • hfrc
  • HFRC1
  • SQV7L
  • UGTrel8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.96
virus perturbation
0.92
histone modification site profile
0.63
transcription factor perturbation
0.61
cellular component
0.57


Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.75   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.75   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
3
6
9
90.3
platelet count
4
2
4
87.8
mean platelet volume
3
2
3
85.3
self reported educational attainment
2
2
2
75.7
BMI-adjusted waist circumference
1
2
2
67.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
9
90.3
platelet count
4
87.8
mean platelet volume
3
85.3
self reported educational attainment
2
75.7
BMI-adjusted waist circumference
2
67.7
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 35 member D2
VGNC:13964
742164
Macaque
solute carrier family 35 member D2
719257
Mouse
MGI:1917734
70484
Rat
RGD:1309518
290959
Dog
solute carrier family 35 member D2
VGNC:46371
100856233
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 35 member D2
Macaque
solute carrier family 35 member D2
Mouse
Rat
Dog
solute carrier family 35 member D2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q76EJ3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (11)
Glycosaminoglycan metabolism (R-HSA-1630316)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycosaminoglycan metabolism
Reactome
HS-GAG biosynthesis
Reactome
Heparan sulfate/heparin (HS-GAG) metabolism
Reactome
Keratan sulfate biosynthesis
Reactome
Keratan sulfate/keratin metabolism
Name
Explore in Pharos
Explore in Source
Glycosaminoglycan metabolism
HS-GAG biosynthesis
Heparan sulfate/heparin (HS-GAG) metabolism
Keratan sulfate biosynthesis
Keratan sulfate/keratin metabolism
Protein-Protein Interactions (52)
1 – 10 of 52
SLC35A3
Tbio
Family:  Transporter
Novelty:  0.02472244
Score:  0.873
Data Source:  STRINGDB
B4GALT1
Tbio
Family:  Enzyme
Novelty:  0.0073693
Score:  0.8
Data Source:  STRINGDB
SLC35B4
Tbio
Family:  Transporter
Novelty:  0.06873345
Score:  0.783
Data Source:  STRINGDB
SLC35C2
Tdark
Family:  Transporter
Novelty:  0.27116526
Score:  0.749
Data Source:  STRINGDB
ZNF367
Tbio
Family:  TF
Novelty:  0.27340562
Score:  0.735
Data Source:  STRINGDB
ZNF366
Tbio
Family:  TF
Novelty:  0.1166487
Score:  0.725
Data Source:  STRINGDB
B4GALT3
Tbio
Family:  Enzyme
Novelty:  0.04015046
Score:  0.722
Data Source:  STRINGDB
THNSL2
Tbio
Family:  Enzyme
Novelty:  0.01548751
Score:  0.72
Data Source:  STRINGDB
MANEA
Tbio
Family:  Enzyme
Novelty:  0.03693244
Score:  0.712
Data Source:  STRINGDB
MGAT5B
Tbio
Family:  Enzyme
Novelty:  0.07278117
Score:  0.71
Data Source:  STRINGDB
Publication Statistics
PubMed Score  8.75

PubMed score by year
PubTator Score  7.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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