Tbio ANO5 Anoctamin-5

Protein Summary

Description

Does not exhibit calcium-activated chloride channel (CaCC) activity. This gene encodes a member of the anoctamin family of transmembrane proteins. The encoded protein is likely a calcium activated chloride channel. Mutations in this gene have been associated with gnathodiaphyseal dysplasia. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2009]

Uniprot Accession IDs

• Q75V66

Gene Name

• ANO5

Ensembl ID

• ENST00000324559
• ENSP00000315371
• ENSG00000171714

Symbol

• GDD1
• TMEM16E
• GDD1
• LGMD2L
• LGMDR12
• TMEM16E

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.78
histone modification site profile	0.69
microRNA	0.67
cellular component	0.64
tissue sample	0.64

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 116.99   (req: < 5)

Gene RIFs: 45   (req: <= 3)

Antibodies: 72   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 116.99   (req: >= 5)

Gene RIFs: 45   (req: > 3)

Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0