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Tbio
PGAP1
GPI inositol-deacylase

Protein Summary
Description
Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi (By similarity). The protein encoded by this gene functions early in the glycosylphosphatidylinositol (GPI) biosynthetic pathway, catalyzing the inositol deacylation of GPI. The encoded protein is required for the production of GPI that can attach to proteins, and this may be an important factor in the transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi. Defects in this gene are a cause an autosomal recessive form of cognitive impairment. [provided by RefSeq, Jul 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354764
  • ENSP00000346809
  • ENSG00000197121
  • ENST00000409475
  • ENSP00000387028

Symbol
  • Bst1
  • MRT42
  • SPG67
  • ISPD3024
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
kinase perturbation
0.76
virus perturbation
0.64
microRNA
0.63
cellular component
0.62


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.16   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 31   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.16   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 31   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (60)
SCGB1D1
Tbio
Novelty:  0.04199997
p_int:  0.980998051
p_ni:  0.019001949
Data Source:  BioPlex
TCTN2
Tbio
Novelty:  0.11617528
p_int:  0.977256625
p_ni:  0.022743375
Data Source:  BioPlex
HYOU1
Tbio
Novelty:  0.00833649
p_int:  0.936562108
p_ni:  0.063437892
Data Source:  BioPlex
UPK1A
Tbio
Novelty:  0.01748122
p_int:  0.88678817
p_ni:  0.11321183
Data Source:  BioPlex
CHRNB4
Tclin
Family:  IC
Novelty:  0.01151716
p_int:  0.879198991
p_ni:  0.120801005
p_wrong:  4e-9
Data Source:  BioPlex
NRG1
Tbio
Novelty:  0.00095246
p_int:  0.845767352
p_ni:  0.154232648
Data Source:  BioPlex
MCOLN3
Tchem
Family:  IC
Novelty:  0.03209262
p_int:  0.806119791
p_ni:  0.193880205
p_wrong:  4e-9
Score:  0.16
Data Source:  BioPlex,STRINGDB
NCEH1
Tchem
Family:  Enzyme
Novelty:  0.01528589
p_int:  0.797284005
p_ni:  0.20271599
p_wrong:  4e-9
Score:  0.202
Data Source:  BioPlex,STRINGDB
ISLR
Tbio
Novelty:  0.02936208
p_int:  0.757552425
p_ni:  0.242447575
Score:  0.158
Data Source:  BioPlex,STRINGDB
PIGT
Tbio
Family:  Enzyme
Novelty:  0.02539879
Score:  0.966
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Attachment of GPI anchor to uPAR (R-HSA-162791)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Attachment of GPI anchor to uPAR
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Attachment of GPI anchor to uPAR
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
1
1
28.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
28.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
post-GPI attachment to proteins 1
VGNC:14337
745391
Mouse
MGI:2443342
241062
Rat
RGD:1303213
316400
Dog
post-GPI attachment to proteins 1
VGNC:44452
612828
Horse
post-GPI attachment to proteins 1
VGNC:21347
100070459
Species
Name
OMA
EggNOG
Inparanoid
Chimp
post-GPI attachment to proteins 1
Mouse
Rat
Dog
post-GPI attachment to proteins 1
Horse
post-GPI attachment to proteins 1
Publication Statistics
PubMed Score 21.16
PubMed score by year
PubTator Score 9.15
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title