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Tbio
FBN3
Fibrillin-3

Protein Summary
Description
Fibrillin-3: Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-containing microfibrils provide long-term force bearing structural support. This gene encodes a memebr of the fibrillin protein family. Fibrillins are extracellular matrix molecules that assemble into microfibrils in many connective tissues. This gene is most highly expressed in fetal tissues and its protein product is localized to extracellular microfibrils of developing skeletal elements, skin, lung, kidney, and skeletal muscle. This gene is potentially involved in Weill-Marchesani syndrome. [provided by RefSeq, Mar 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000270509
  • ENSP00000270509
  • ENSG00000142449
  • ENST00000600128
  • ENSP00000470498
  • ENST00000601739
  • ENSP00000472324

Symbol
  • KIAA1776
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
disease
0.49
trait
0.46
metabolite
0.45
phenotype
0.42


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.55   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 27   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.55   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 27   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (38)
MFAP2
Tbio
Novelty:  0.01599653
Score:  0.945
Data Source:  STRINGDB
FURIN
Tchem
Family:  Enzyme
Novelty:  0.00055079
Score:  0.936
Data Source:  STRINGDB
MFAP5
Tbio
Novelty:  0.01839035
Score:  0.925
Data Source:  STRINGDB
ITGAV
Tchem
Novelty:  0.00148589
Score:  0.909
Data Source:  STRINGDB
ITGA5
Tbio
Novelty:  0.00285802
Score:  0.909
Data Source:  STRINGDB
ITGB1
Tclin
Novelty:  0.00055626
Score:  0.905
Data Source:  STRINGDB
ITGB3
Tclin
Novelty:  0.00067255
Score:  0.905
Data Source:  STRINGDB
ITGB6
Tbio
Novelty:  0.01118242
Score:  0.904
Data Source:  STRINGDB
FBN1
Tbio
Novelty:  0.00074957
Score:  0.902
Data Source:  STRINGDB
FBN2
Tbio
Novelty:  0.00549053
Score:  0.901
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Elastic fibre formation (R-HSA-1566948)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Elastic fibre formation
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Elastic fibre formation
Extracellular matrix organization
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
very long-chain saturated fatty acid measurement
3
2
0
10
91.9
sphingolipid measurement
3
2
4
91
serum metabolite measurement
1
4
7
88.5
CCL25 measurement
1
1
1
81.9
blood metabolite measurement
1
1
2
77.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
very long-chain saturated fatty acid measurement
0
10
91.9
sphingolipid measurement
4
91
serum metabolite measurement
7
88.5
CCL25 measurement
1
81.9
blood metabolite measurement
2
77.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fibrillin 3
VGNC:2409
455669
Dog
fibrillin 3
VGNC:40756
485006
Opossum
fibrillin 3
100025912
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fibrillin 3
Dog
fibrillin 3
Opossum
fibrillin 3
Publication Statistics
PubMed Score 23.55
PubMed score by year
PubTator Score 21.28
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title