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Tbio
CBLL1
E3 ubiquitin-protein ligase Hakai

Protein Summary
Description
E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1 (By similarity). Targets CDH1 for endocytosis and degradation (By similarity). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Its function in the WMM complex is unknown (PubMed:29507755). This gene encodes an E3 ubiquitin-ligase for the E-cadherin complex and mediates its ubiquitination, endocytosis, and degradation in the lysosomes. The encoded protein contains a RING-finger domain and is also thought to have a role in control of cell proliferation. A related pseudogene has been identified on chromosome X. Alternative splicing results in a non-coding transcript variant. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222597
  • ENSP00000222597
  • ENSG00000105879
  • ENST00000440859
  • ENSP00000401277

Symbol
  • HAKAI
  • RNF188
  • HAKAI
  • RNF188
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.95
histone modification site profile
0.73
transcription factor
0.64
cell type or tissue
0.58
protein domain
0.58


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.99   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 188   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.99   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (38)
WTAP
Tbio
Novelty:  0.01491546
Score:  0.999
Data Source:  STRINGDB
VIRMA
Tbio
Novelty:  0.05400878
Score:  0.999
Data Source:  STRINGDB
CDH1
Tbio
Novelty:  0.00010629
Score:  0.984
Data Source:  Reactome,STRINGDB
METTL14
Tbio
Family:  Enzyme
Novelty:  0.01377112
Score:  0.965
Data Source:  STRINGDB
ZC3H13
Tbio
Novelty:  0.0990341
Score:  0.96
Data Source:  STRINGDB
METTL3
Tbio
Family:  Enzyme
Novelty:  0.00420954
Score:  0.947
Data Source:  STRINGDB
RBM15
Tbio
Novelty:  0.00948292
Score:  0.921
Data Source:  STRINGDB
CTNNB1
Tchem
Novelty:  0.0000744
Score:  0.917
Data Source:  Reactome,STRINGDB
RBM15B
Tbio
Novelty:  0.15620369
Score:  0.904
Data Source:  STRINGDB
SLC16A4
Tbio
Family:  Transporter
Novelty:  0.0042395
Score:  0.851
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Infectious disease
Reactome
InlA-mediated entry of Listeria monocytogenes into host cells
Reactome
Listeria monocytogenes entry into host cells
Name
Explore in Pharos
Explore in Source
Disease
Infectious disease
InlA-mediated entry of Listeria monocytogenes into host cells
Listeria monocytogenes entry into host cells
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
3
0
1.1
79.3
lymphocyte count
2
2
2
51.7
alkaline phosphatase measurement
1
1
1
21.5
1
1
0
1.1
13.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
79.3
lymphocyte count
2
51.7
alkaline phosphatase measurement
1
21.5
0
1.1
13.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Cbl proto-oncogene like 1
VGNC:7355
472482
Macaque
Cbl proto-oncogene like 1
699980
Mouse
MGI:2144842
104836
Rat
RGD:1310703
314028
Dog
Cbl proto-oncogene like 1
483262
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Cbl proto-oncogene like 1
Macaque
Cbl proto-oncogene like 1
Mouse
Rat
Dog
Cbl proto-oncogene like 1
Publication Statistics
PubMed Score 31.99
PubMed score by year
PubTator Score 10.55
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title