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Tbio
CBLL1
E3 ubiquitin-protein ligase Hakai

Protein Classes
Protein Summary
Description
E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1 (By similarity). Targets CDH1 for endocytosis and degradation (By similarity). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Its function in the WMM complex is unknown (PubMed:29507755). This gene encodes an E3 ubiquitin-ligase for the E-cadherin complex and mediates its ubiquitination, endocytosis, and degradation in the lysosomes. The encoded protein contains a RING-finger domain and is also thought to have a role in control of cell proliferation. A related pseudogene has been identified on chromosome X. Alternative splicing results in a non-coding transcript variant. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222597
  • ENSP00000222597
  • ENSG00000105879
  • ENST00000440859
  • ENSP00000401277

Symbol
  • HAKAI
  • RNF188
  • HAKAI
  • RNF188
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.95
histone modification site profile
0.73
transcription factor
0.64
cell type or tissue
0.58
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.41   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 188   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.41   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (6)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Infectious disease
Reactome
InlA-mediated entry of Listeria monocytogenes into host cells
Reactome
Listeria monocytogenes entry into host cells
Name
Explore in Pharos
Explore in Source
Disease
Infectious disease
InlA-mediated entry of Listeria monocytogenes into host cells
Listeria monocytogenes entry into host cells
Protein-Protein Interactions (38)
1 – 10 of 38
WTAP
Tbio
Novelty: 0.04562162
Score: 0.999
Data Source: STRINGDB
VIRMA
Tbio
Novelty: 0.18963052
Score: 0.999
Data Source: STRINGDB
CDH1
Tbio
Novelty: 0.0001303
Score: 0.984
Data Source: Reactome,STRINGDB
METTL14
Tbio
Family: Enzyme
Novelty: 0.035504
Score: 0.965
Data Source: STRINGDB
ZC3H13
Tbio
Novelty: 0.24992562
Score: 0.96
Data Source: STRINGDB
METTL3
Tbio
Family: Enzyme
Novelty: 0.01066956
Score: 0.947
Data Source: STRINGDB
RBM15
Tbio
Novelty: 0.01332138
Score: 0.921
Data Source: STRINGDB
CTNNB1
Tchem
Novelty: 0.00008951
Score: 0.917
Data Source: Reactome,STRINGDB
RBM15B
Tbio
Novelty: 0.38391225
Score: 0.904
Data Source: STRINGDB
SLC16A4
Tbio
Family: Transporter
Novelty: 0.00606708
Score: 0.851
Data Source: STRINGDB
Publication Statistics
PubMed Score  17.41

PubMed score by year
PubTator Score  10.55

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer