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Tbio
H2AFV
Histone H2A.V

Protein Summary
Description
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division (By similarity). Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker h ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222690
  • ENSP00000222690
  • ENSG00000105968
  • ENST00000308153
  • ENSP00000308405
  • ENST00000349299
  • ENSP00000342714
  • ENST00000350771
  • ENSP00000340708
  • ENST00000381124
  • ENSP00000370516

Symbol
  • H2AV
  • H2AV
  • H2A.Z-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
1
transcription factor perturbation
0.98
co-expressed gene
0.85
cellular component
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.63   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 66   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.63   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (498)
1 – 10 of 498
HIST1H2BO
Tdark
Novelty:  0.3427419
Score:  0.997
Data Source:  STRINGDB
HIST2H2BF
Tdark
Novelty:  1.40321359
Score:  0.99
Data Source:  STRINGDB
H2BFS
Tbio
Novelty:  0.12796183
Score:  0.985
Data Source:  STRINGDB
HIST1H2BK
Tbio
Novelty:  0.12867647
Score:  0.984
Data Source:  STRINGDB
HIST1H2BJ
Tbio
Novelty:  0.14308844
Score:  0.982
Data Source:  STRINGDB
CDK1
Tchem
Family:  Kinase
Novelty:  0.00040776
Score:  0.979
Data Source:  STRINGDB
HIST2H2BE
Tbio
Novelty:  0.00024381
Score:  0.976
Data Source:  STRINGDB
KAT5
Tchem
Family:  Epigenetic
Novelty:  0.00368348
Score:  0.976
Data Source:  STRINGDB
HIST1H2BB
Tbio
Novelty:  0.20192804
Score:  0.975
Data Source:  STRINGDB
KDM1A
Tchem
Family:  Epigenetic
Novelty:  0.00142673
Score:  0.975
Data Source:  STRINGDB
Pathways (76)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (R-HSA-5625886)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 71
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
B-WICH complex positively regulates rRNA expression
Reactome
Base Excision Repair
Name
Explore in Pharos
Explore in Source
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
B-WICH complex positively regulates rRNA expression
Base Excision Repair
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
2
2
95.1
platelet count
2
2
2
88.5
mean reticulocyte volume
1
1
1
86.4
mean corpuscular volume
1
1
1
86
mean corpuscular hemoglobin concentration
1
1
1
84.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
95.1
platelet count
2
88.5
mean reticulocyte volume
1
86.4
mean corpuscular volume
1
86
mean corpuscular hemoglobin concentration
1
84.6
Find similar targets by:
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
H2A histone family member V
VGNC:14019
453664
Macaque
histone H2A.V-like
705636
Mouse
MGI:1924855
77605
Rat
RGD:1587865
685909
Dog
H2A histone family, member V
475501
Species
Name
OMA
EggNOG
Inparanoid
Chimp
H2A histone family member V
Macaque
histone H2A.V-like
Mouse
Rat
Dog
H2A histone family, member V
Publication Statistics
PubMed Score 25.63
PubMed score by year
PubTator Score 10.66
PubTator score by year