Tchem TUBA1A Tubulin alpha-1A chain

Protein Summary

Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to the mouse and rat Tuba1 genes. Northern blot studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q. Mutations in this gene cause lissencephaly type 3 (LIS3) - a neurological condition characterized by microcephaly, intellectual disability, and early-onset epilepsy caused by defective neuronal migration. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2017]

Uniprot Accession IDs

• Q71U36
• A8K0B8
• G3V1U9
• P04687
• P05209

Gene Name

• TUBA1A

Ensembl ID

• ENST00000295766
• ENSP00000439020
• ENSG00000167552
• ENST00000301071
• ENSP00000301071
• ENST00000550767
• ENSP00000446637

Symbol

• TUBA3
• LIS3
• TUBA3
• B-ALPHA-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	1
kinase perturbation	0.97
disease perturbation	0.95
molecular function	0.95
protein domain	0.92

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Microtubule Family Cytoskeletal Protein / Tubulin / Tubulin Alpha-1a Chain

DTO Classes

Protein / Cellular Structure / Microtubule Family Cytoskeletal Protein / Tubulin / Tubulin Alpha-1a Chain

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.33   (req: < 5)

Gene RIFs: 43   (req: <= 3)

Antibodies: 578   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.33   (req: >= 5)

Gene RIFs: 43   (req: > 3)

Antibodies: 578   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1