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Tchem
TUBA1A
Tubulin alpha-1A chain

Protein Summary
Description
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to the mouse and rat Tuba1 genes. Northern blot studies have shown that the gene expression is predominantly found in morphologically differentiated neurologi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295766
  • ENSP00000439020
  • ENSG00000167552
  • ENST00000301071
  • ENSP00000301071
  • ENST00000550767
  • ENSP00000446637

Symbol
  • TUBA3
  • LIS3
  • TUBA3
  • B-ALPHA-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
kinase perturbation
0.97
disease perturbation
0.95
molecular function
0.95
protein domain
0.92


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.88   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 578   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.88   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 578   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tubulin alpha 1a
VGNC:13486
451875
Macaque
tubulin alpha-1C chain
710110
Mouse
MGI:98869
22142
Rat
RGD:619717
64158
Cow
tubulin, alpha 1b
539882
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tubulin alpha 1a
Macaque
tubulin alpha-1C chain
Mouse
Rat
Cow
tubulin, alpha 1b
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q71U36-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (50)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 25
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Carboxyterminal post-translational modifications of tubulin
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Anchoring of the basal body to the plasma membrane
Carboxyterminal post-translational modifications of tubulin
Cell Cycle
Cell Cycle, Mitotic
Gene Ontology Terms (26)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (312)
1 – 10 of 312
TCP11L2
Tdark
Novelty: 1.78903335
p_int: 0.999987147
p_ni: 0.000012853
Score: 0.795
Data Source: BioPlex,STRINGDB
TXNDC9
Tbio
Novelty: 0.00309772
p_int: 0.997582939
p_ni: 0.002417061
Score: 0.393
Data Source: BioPlex,STRINGDB
CAPS
Tbio
Novelty: 0.04549022
p_int: 0.997212706
p_ni: 0.002787294
Data Source: BioPlex
TTC5
Tbio
Novelty: 0.12127698
p_int: 0.993048234
p_ni: 0.006951766
Score: 0.541
Data Source: BioPlex,STRINGDB
CD79B
Tclin
Novelty: 0.00227414
p_int: 0.981655374
p_ni: 0.018344626
Data Source: BioPlex
OSTM1
Tbio
Novelty: 0.03033192
p_int: 0.978615965
p_ni: 0.021384035
Data Source: BioPlex
SNX21
Tdark
Novelty: 0.32916633
p_int: 0.971303384
p_ni: 0.028696616
Data Source: BioPlex
CTDSP1
Tbio
Family: Enzyme
Novelty: 0.0231786
p_int: 0.96984764
p_ni: 0.03015236
Score: 0.175
Data Source: BioPlex,STRINGDB
GLMP
Tdark
Novelty: 0.10163099
p_int: 0.968280779
p_ni: 0.031719221
Data Source: BioPlex
TUBA3C
Tchem
Novelty: 0.0187396
p_int: 0.960492426
p_ni: 0.039507574
Data Source: BioPlex
Publication Statistics
PubMed Score  90.88

PubMed score by year
PubTator Score  44.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer