Tchem TUBA1A Tubulin alpha-1A chain

Protein Summary

Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to the mouse and rat Tuba1 genes. Northern blot studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q. Mutations in this gene cause lissencephaly type 3 (LIS3) - a neurological condition characterized by microcephaly, intellectual disability, and early-onset epilepsy caused by defective neuronal migration. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2017]

Uniprot Accession IDs

• Q71U36
• A8K0B8
• G3V1U9
• P04687
• P05209

Gene Name

• TUBA1A

Ensembl ID

• ENST00000295766
• ENSP00000439020
• ENSG00000167552
• ENST00000301071
• ENSP00000301071
• ENST00000550767
• ENSP00000446637

Symbol

• TUBA3
• LIS3
• TUBA3
• B-ALPHA-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	1
kinase perturbation	0.97
disease perturbation	0.95
molecular function	0.95
protein domain	0.92

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Microtubule Family Cytoskeletal Protein / Tubulin / Tubulin Alpha-1a Chain

DTO Classes

Protein / Cellular Structure / Microtubule Family Cytoskeletal Protein / Tubulin / Tubulin Alpha-1a Chain

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.86   (req: < 5)

Gene RIFs: 43   (req: <= 3)

Antibodies: 578   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.86   (req: >= 5)

Gene RIFs: 43   (req: > 3)

Antibodies: 578   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (1)

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1 – 1 of 1

podophyllotoxin

TUBA1ATchem

pIC50 : 7.85

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (312)

Explore Interacting Targets

1 – 10 of 312

• See Interactions on String-DB

TCP11L2

Tdark

Novelty:  1.78903335

p_int:  0.999987147

p_ni:  0.000012853

Score:  0.795

Data Source:  BioPlex,STRINGDB

TXNDC9

Tbio

Novelty:  0.00309772

p_int:  0.997582939

p_ni:  0.002417061

Score:  0.393

Data Source:  BioPlex,STRINGDB

CAPS

Tbio

Novelty:  0.04549022

p_int:  0.997212706

p_ni:  0.002787294

Data Source:  BioPlex

TTC5

Tbio

Novelty:  0.12127698

p_int:  0.993048234

p_ni:  0.006951766

Score:  0.541

Data Source:  BioPlex,STRINGDB

CD79B

Tclin

Novelty:  0.00227414

p_int:  0.981655374

p_ni:  0.018344626

Data Source:  BioPlex

OSTM1

Tbio

Novelty:  0.03033192

p_int:  0.978615965

p_ni:  0.021384035

Data Source:  BioPlex

SNX21

Tdark

Novelty:  0.32916633

p_int:  0.971303384

p_ni:  0.028696616

Data Source:  BioPlex

CTDSP1

Tchem

Family:  Enzyme

Novelty:  0.0231786

p_int:  0.96984764

p_ni:  0.03015236

Score:  0.175

Data Source:  BioPlex,STRINGDB

GLMP

Tdark

Novelty:  0.10163099

p_int:  0.968280779

p_ni:  0.031719221

Data Source:  BioPlex

TUBA3C

Tchem

Novelty:  0.0187396

p_int:  0.960492426

p_ni:  0.039507574

Data Source:  BioPlex

Nearest Tclin Targets (18)

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Upstream (9)

Downstream (9)

1 – 5 of 9

TUBB2A

Tclin

Family:  Other

KEGG Distance:  1

Common Pathways:  3

1: Phagosome

2: Gap junction

3: Pathogenic Escherichia coli infection

TUBB4B

Tclin

Family:  Other

KEGG Distance:  1

Common Pathways:  3

1: Phagosome

2: Gap junction

3: Pathogenic Escherichia coli infection

TUBB6

Tclin

Family:  Other

KEGG Distance:  1

Common Pathways:  3

1: Phagosome

2: Gap junction

3: Pathogenic Escherichia coli infection

TUBB4A

Tclin

Family:  Other

KEGG Distance:  1

Common Pathways:  3

1: Phagosome

2: Gap junction

3: Pathogenic Escherichia coli infection

TUBB

Tclin

Family:  Other

KEGG Distance:  1

Common Pathways:  3

1: Phagosome

2: Gap junction

3: Pathogenic Escherichia coli infection

Pathways (50)

Reactome (25)

KEGG (5)

PathwayCommons (2)

WikiPathways (18)

AURKA Activation by TPX2 (R-HSA-8854518)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	AURKA Activation by TPX2	72 targets	R-HSA-8854518
Reactome	Anchoring of the basal body to the plasma membrane	97 targets	R-HSA-5620912
Reactome	Carboxyterminal post-translational modifications of tubulin	38 targets	R-HSA-8955332
Reactome	Cell Cycle	597 targets	R-HSA-1640170
Reactome	Cell Cycle, Mitotic	495 targets	R-HSA-69278

Name	Explore in Pharos	Explore in Source
AURKA Activation by TPX2	72 targets	R-HSA-8854518
Anchoring of the basal body to the plasma membrane	97 targets	R-HSA-5620912
Carboxyterminal post-translational modifications of tubulin	38 targets	R-HSA-8955332
Cell Cycle	597 targets	R-HSA-1640170
Cell Cycle, Mitotic	495 targets	R-HSA-69278

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (26)

Functions (5)

Components (12)

Processes (9)

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Items per page:

10

1 – 5 of 5

GO Term	Evidence	Assigned by
GTP binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
structural constituent of cytoskeleton	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
structural molecule activity	Traceable Author Statement (TAS)	BHF-UCL
GTPase activity	Inferred from Electronic Annotation (IEA)	InterPro
protein domain specific binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations ()

No disease associations found

GWAS Traits (10)

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5

1 – 5 of 10

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	3	2	3		90.2
platelet count	EFO_0004309	2	2	2		81.1
HbA1c measurement	EFO_0004541	1	1	1		57.8
bone density	EFO_0003923	1	1	2		53.3
mean corpuscular hemoglobin concentration	EFO_0004528	1	1	1		51.7

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	3		90.2
platelet count	EFO_0004309	2		81.1
HbA1c measurement	EFO_0004541	1		57.8
bone density	EFO_0003923	2		53.3
mean corpuscular hemoglobin concentration	EFO_0004528	1		51.7

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Disease mutation
GTP-binding
Isopeptide bond

GWAS Trait Find Similar Targets

No Header	No Header
bone density
cognitive function measurement
comparative body size at age 10, self-reported
HbA1c measurement
intelligence
mean corpuscular hemoglobin concentration
mean platelet volume
platelet count
prostate carcinoma
self reported educational attainment

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cellular phenotype
growth/size/body region phenotype
nervous system phenotype

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	tubulin alpha 1a	VGNC:13486	451875
Macaque	tubulin alpha-1C chain		710110
Mouse	tubulin, alpha 1A	MGI:98869	22142
Rat	tubulin, alpha 1A	RGD:619717	64158
Cow	tubulin, alpha 1b		539882

Species	Name	OMA	EggNOG	Inparanoid
Chimp	tubulin alpha 1a
Macaque	tubulin alpha-1C chain
Mouse	tubulin, alpha 1A
Rat	tubulin, alpha 1A
Cow	tubulin, alpha 1b

Publication Statistics

PubMed Score 93.86

PubMed score by year

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PubTator Score 44.25

PubTator score by year

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Related Publications

Text Mined References (91)

GeneRif Annotations (43)

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10

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PMID	Year	Title