Protein Summary
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to the mouse and rat Tuba1 genes. Northern blot studies have shown that the gene expression is predominantly found in morphologically differentiated neurologi ...more
- ENST00000295766
- ENSP00000439020
- ENSG00000167552
- ENST00000301071
- ENSP00000301071
- ENST00000550767
- ENSP00000446637
- TUBA3
- LIS3
- TUBA3
- B-ALPHA-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
hub protein | 1 | ||
kinase perturbation | 0.97 | ||
disease perturbation | 0.95 | ||
molecular function | 0.95 | ||
protein domain | 0.92 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 93.86 (req: < 5)
Gene RIFs: 43 (req: <= 3)
Antibodies: 578 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 93.86 (req: >= 5)
Gene RIFs: 43 (req: > 3)
Antibodies: 578 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (0)
Protein-Protein Interactions (312)
TCP11L2
Novelty: 1.78903335
p_int: 0.999987147
p_ni: 0.000012853
Score: 0.795
Data Source: BioPlex,STRINGDB
TXNDC9
Novelty: 0.00309772
p_int: 0.997582939
p_ni: 0.002417061
Score: 0.393
Data Source: BioPlex,STRINGDB
TTC5
Novelty: 0.12127698
p_int: 0.993048234
p_ni: 0.006951766
Score: 0.541
Data Source: BioPlex,STRINGDB
CTDSP1
Family: Enzyme
Novelty: 0.0231786
p_int: 0.96984764
p_ni: 0.03015236
Score: 0.175
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (18)
Upstream (9)
Downstream (9)
1 – 5 of 9
Pathways (50)
Reactome (25)
KEGG (5)
PathwayCommons (2)
WikiPathways (18)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | AURKA Activation by TPX2 | ||||
Reactome | Anchoring of the basal body to the plasma membrane | ||||
Reactome | Carboxyterminal post-translational modifications of tubulin | ||||
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle, Mitotic | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
AURKA Activation by TPX2 | ||||
Anchoring of the basal body to the plasma membrane | ||||
Carboxyterminal post-translational modifications of tubulin | ||||
Cell Cycle | ||||
Cell Cycle, Mitotic | ||||
Viral Interactions (0)
Gene Ontology Terms (26)
Functions (5)
Components (12)
Processes (9)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
mean platelet volume | 3 | 2 | 3 | 90.2 | |||||
platelet count | 2 | 2 | 2 | 81.1 | |||||
HbA1c measurement | 1 | 1 | 1 | 57.8 | |||||
bone density | 1 | 1 | 2 | 53.3 | |||||
mean corpuscular hemoglobin concentration | 1 | 1 | 1 | 51.7 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
mean platelet volume | 3 | 90.2 | |||||
platelet count | 2 | 81.1 | |||||
HbA1c measurement | 1 | 57.8 | |||||
bone density | 2 | 53.3 | |||||
mean corpuscular hemoglobin concentration | 1 | 51.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | tubulin alpha 1a | VGNC:13486 | 451875 | |||||
Macaque | tubulin alpha-1C chain | 710110 | ||||||
Mouse | MGI:98869 | 22142 | ||||||
Rat | RGD:619717 | 64158 | ||||||
Cow | tubulin, alpha 1b | 539882 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | tubulin alpha 1a | |||||
Macaque | tubulin alpha-1C chain | |||||
Mouse | ||||||
Rat | ||||||
Cow | tubulin, alpha 1b | |||||
Publication Statistics
PubMed Score 93.86
PubMed score by year
PubTator Score 44.25
PubTator score by year
Related Publications
Text Mined References (91)
GeneRif Annotations (43)
Items per page:
0 of 0
PMID | Year | Title |
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