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Tbio
SLC24A5
Sodium/potassium/calcium exchanger 5

Protein Summary
Description
Cation exchanger involved in pigmentation, possibly by participating in ion transport in melanosomes. Predominant sodium-Calcium exchanger in melanocytes. Probably transports 1 Ca(2+) and 1 K(+) to the melanosome in exchange for 4 cytoplasmic Na(+). This gene is a member of the potassium-dependent sodium/calcium exchanger family and encodes an intracellular membrane protein with 2 large hydrophilic loops and 2 sets of multiple transmembrane-spanning segments. Sequence variation in this gene has been associated with differences in skin pigmentation. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341459
  • ENSP00000341550
  • ENSG00000188467
  • ENST00000449382
  • ENSP00000389966

Symbol
  • JSX
  • NCKX5
  • JSX
  • OCA6
  • NCKX5
  • SHEP4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.79
tissue
0.6
cellular component
0.53
tissue sample
0.51
transcription factor
0.51


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.57   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 86   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.57   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 86   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
skin pigmentation measurement
2
2
1
3.5
97.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
skin pigmentation measurement
1
3.5
97.1
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 24 member 5
VGNC:7776
453408
Macaque
solute carrier family 24 member 5
714236
Mouse
MGI:2677271
317750
Rat
RGD:1310565
311387
Dog
solute carrier family 24 member 5
VGNC:46289
612878
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 24 member 5
Macaque
solute carrier family 24 member 5
Mouse
Rat
Dog
solute carrier family 24 member 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q71RS6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6) (R-HSA-5619036)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6)
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Reactome
SLC transporter disorders
Reactome
SLC-mediated transmembrane transport
Name
Explore in Pharos
Explore in Source
Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6)
Disease
Disorders of transmembrane transporters
SLC transporter disorders
SLC-mediated transmembrane transport
Protein-Protein Interactions (53)
1 – 10 of 53
ABCB10
Tbio
Family: Transporter
Novelty: 0.00351852
p_int: 0.989736473
p_ni: 0.010263526
p_wrong: 1e-9
Score: 0.214
Data Source: BioPlex,STRINGDB
TMEM186
Tdark
Novelty: 0.59951294
p_int: 0.98248061
p_ni: 0.01751939
Score: 0.187
Data Source: BioPlex,STRINGDB
SYVN1
Tbio
Family: Enzyme
Novelty: 0.02216474
p_int: 0.766127345
p_ni: 0.233872654
Score: 0.296
Data Source: BioPlex,STRINGDB
SLC45A2
Tbio
Family: Transporter
Novelty: 0.00268252
Score: 0.945
Data Source: STRINGDB
OCA2
Tbio
Novelty: 0.00249611
Score: 0.93
Data Source: STRINGDB
TYRP1
Tbio
Family: Enzyme
Novelty: 0.00062138
Score: 0.875
Data Source: STRINGDB
TYR
Tclin
Family: Enzyme
Novelty: 0.00048513
Score: 0.862
Data Source: STRINGDB
TPCN2
Tchem
Family: IC
Novelty: 0.01351129
Score: 0.758
Data Source: STRINGDB
EDA2R
Tbio
Novelty: 0.03463669
Score: 0.747
Data Source: STRINGDB
PMEL
Tbio
Novelty: 0.00116525
Score: 0.745
Data Source: STRINGDB
Publication Statistics
PubMed Score  82.57

PubMed score by year
PubTator Score  41.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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