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Tbio
LARP4
La-related protein 4

Protein Summary
Description
RNA binding protein that binds to the poly-A tract of mRNA molecules (PubMed:21098120). Associates with the 40S ribosomal subunit and with polysomes (PubMed:21098120). Plays a role in the regulation of mRNA translation (PubMed:21098120). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987, PubMed:27615744).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000293618
  • ENSP00000293618
  • ENSG00000161813
  • ENST00000347328
  • ENSP00000340901
  • ENST00000398473
  • ENSP00000381490
  • ENST00000429001
  • ENSP00000415464
  • ENST00000518444
  • ENSP00000429077
  • ENST00000522085
  • ENSP00000429781

Symbol
  • PP13296
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
microRNA
0.85
interacting protein
0.84
tissue sample
0.69
transcription factor binding site profile
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.17   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 144   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.17   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 144   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (91)
FBXO10
Tbio
Novelty:  0.18324932
p_int:  0.999482453
p_ni:  0.000517533
p_wrong:  1.4e-8
Data Source:  BioPlex
RACK1
Tbio
Novelty:  0.00200617
p_int:  0.996647058
p_ni:  0.003352942
Score:  0.817
Data Source:  BioPlex,STRINGDB
OMP
Tbio
Novelty:  0.00286211
p_int:  0.936286549
p_ni:  0.06260847
p_wrong:  0.001104981
Data Source:  BioPlex
PABPC1
Tbio
Novelty:  0.00197523
Score:  0.987
Data Source:  STRINGDB
PABPC4
Tbio
Novelty:  0.06854984
Score:  0.848
Data Source:  STRINGDB
PABPC1L
Tbio
Novelty:  0.04037574
Score:  0.841
Data Source:  STRINGDB
PABPC3
Tbio
Novelty:  0.13551529
Score:  0.822
Data Source:  STRINGDB
NCL
Tbio
Novelty:  0.00100905
Score:  0.769
Data Source:  STRINGDB
PABPC4L
Tdark
Novelty:  0.94386609
Score:  0.767
Data Source:  STRINGDB
PABPC1L2A
Tdark
Novelty:  14
Score:  0.767
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
2
2
91.3
platelet count
2
2
2
79.8
leukocyte count
1
1
1
72.9
neutrophil count
1
1
1
66
red blood cell distribution width
1
1
1
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
91.3
platelet count
2
79.8
leukocyte count
1
72.9
neutrophil count
1
66
red blood cell distribution width
1
49.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
La ribonucleoprotein domain family member 4
VGNC:5448
452428
Macaque
La ribonucleoprotein domain family member 4
713773
Mouse
MGI:2443114
207214
Dog
La ribonucleoprotein domain family member 4
VGNC:42589
477609
Horse
La ribonucleoprotein domain family member 4
VGNC:19587
100052331
Species
Name
OMA
EggNOG
Inparanoid
Chimp
La ribonucleoprotein domain family member 4
Macaque
La ribonucleoprotein domain family member 4
Mouse
Dog
La ribonucleoprotein domain family member 4
Horse
La ribonucleoprotein domain family member 4
Publication Statistics
PubMed Score 17.17
PubMed score by year
PubTator Score 3.59
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title