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Tbio
MED13L
Mediator of RNA polymerase II transcription subunit 13-like

Protein Summary
Description
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. The protein encoded by this gene is a subunit of the Mediator complex, a large complex of proteins that functions as a transcriptional coactivator for most RNA polymerase II-transcribed genes. The encoded protein is involved in early development of the heart and brain. Defects in this gene are a cause of transposition of the great arteries, dextro-looped (DTGA).[prov ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000281928
  • ENSP00000281928
  • ENSG00000123066

Symbol
  • KIAA1025
  • PROSIT240
  • THRAP2
  • TRAP240L
  • MRFACD
  • THRAP2
  • TRAP240L
  • PROSIT240
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
transcription factor binding site profile
0.9
transcription factor perturbation
0.88
drug perturbation
0.87
microRNA
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.62   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.62   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
1
2
82.7
self reported educational attainment
1
1
1
63.6
pulse pressure measurement
1
1
1
33.7
1
1
0
1.1
27.2
bone density
1
1
1
19.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
82.7
self reported educational attainment
1
63.6
pulse pressure measurement
1
33.7
0
1.1
27.2
bone density
1
19.9
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mediator complex subunit 13 like
VGNC:8467
452281
Macaque
mediator complex subunit 13 like
713867
Mouse
MGI:2670178
76199
Rat
RGD:1305884
360817
Dog
mediator complex subunit 13 like
VGNC:43123
477496
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mediator complex subunit 13 like
Macaque
mediator complex subunit 13 like
Mouse
Rat
Dog
mediator complex subunit 13 like
Pathways (7)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PPARA activates gene expression
Reactome
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Name
Explore in Pharos
Explore in Source
Developmental Biology
Metabolism
Metabolism of lipids
PPARA activates gene expression
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (121)
1 – 10 of 121
MED19
Tbio
Family: Enzyme
Novelty: 0.03926689
p_int: 0.999999931
p_ni: 6.8e-8
p_wrong: 1e-9
Score: 0.991
Data Source: BioPlex,STRINGDB
MED21
Tbio
Family: Enzyme
Novelty: 0.06996616
p_int: 0.9999999
p_ni: 9.9e-8
p_wrong: 1e-9
Score: 0.986
Data Source: BioPlex,STRINGDB
MED17
Tbio
Family: Enzyme
Novelty: 0.02984503
p_int: 0.999999757
p_ni: 2.43e-7
Score: 0.953
Data Source: BioPlex,STRINGDB
MED18
Tbio
Family: Enzyme
Novelty: 0.04066825
p_int: 0.999999703
p_ni: 2.96e-7
p_wrong: 1e-9
Score: 0.988
Data Source: BioPlex,STRINGDB
MED10
Tdark
Family: Enzyme
Novelty: 0.02988632
p_int: 0.999998804
p_ni: 0.000001196
Score: 0.995
Data Source: BioPlex,STRINGDB
MED1
Tbio
Family: Enzyme
Novelty: 0.00852082
p_int: 0.999998393
p_ni: 0.000001607
Score: 0.989
Data Source: BioPlex,STRINGDB
MED28
Tbio
Family: Enzyme
Novelty: 0.00362108
p_int: 0.999998215
p_ni: 0.000001785
Score: 0.941
Data Source: BioPlex,STRINGDB
MED20
Tbio
Family: Enzyme
Novelty: 0.02039559
p_int: 0.999998208
p_ni: 0.000001792
Score: 0.919
Data Source: BioPlex,STRINGDB
CCNC
Tbio
Novelty: 0.00585842
p_int: 0.999996511
p_ni: 0.000003489
Score: 0.997
Data Source: BioPlex,STRINGDB
MED7
Tbio
Family: Enzyme
Novelty: 0.04773947
p_int: 0.999986989
p_ni: 0.00001301
Score: 0.994
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  27.62

PubMed score by year
PubTator Score  19.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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