Tbio MED13L Mediator of RNA polymerase II transcription subunit 13-like

Protein Summary

Description

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. The protein encoded by this gene is a subunit of the Mediator complex, a large complex of proteins that functions as a transcriptional coactivator for most RNA polymerase II-transcribed genes. The encoded protein is involved in early development of the heart and brain. Defects in this gene are a cause of transposition of the great arteries, dextro-looped (DTGA).[provided by RefSeq, Jul 2010]

Uniprot Accession IDs

• Q71F56
• A1L469
• Q68DN4
• Q9H8C0
• Q9NSY9
• Q9UFD8
• Q9UPX5

Gene Name

• MED13L

Ensembl ID

• ENST00000281928
• ENSP00000281928
• ENSG00000123066

Symbol

• KIAA1025
• PROSIT240
• THRAP2
• TRAP240L
• MRFACD
• THRAP2
• TRAP240L
• PROSIT240

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.91
transcription factor binding site profile	0.9
transcription factor perturbation	0.88
drug perturbation	0.87
microRNA	0.84

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.68   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 83   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.68   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (121)

Explore Interacting Targets

1 – 10 of 121

• See Interactions on String-DB

MED19

Tbio

Family:  Enzyme

Novelty:  0.03926689

p_int:  0.999999931

p_ni:  6.8e-8

p_wrong:  1e-9

Score:  0.991

Data Source:  BioPlex,STRINGDB

MED21

Tbio

Family:  Enzyme

Novelty:  0.06996616

p_int:  0.9999999

p_ni:  9.9e-8

p_wrong:  1e-9

Score:  0.986

Data Source:  BioPlex,STRINGDB

MED17

Tbio

Family:  Enzyme

Novelty:  0.02984503

p_int:  0.999999757

p_ni:  2.43e-7

Score:  0.953

Data Source:  BioPlex,STRINGDB

MED18

Tbio

Family:  Enzyme

Novelty:  0.04066825

p_int:  0.999999703

p_ni:  2.96e-7

p_wrong:  1e-9

Score:  0.988

Data Source:  BioPlex,STRINGDB

MED10

Tdark

Family:  Enzyme

Novelty:  0.02988632

p_int:  0.999998804

p_ni:  0.000001196

Score:  0.995

Data Source:  BioPlex,STRINGDB

MED1

Tbio

Family:  Enzyme

Novelty:  0.00852082

p_int:  0.999998393

p_ni:  0.000001607

Score:  0.989

Data Source:  BioPlex,STRINGDB

MED28

Tbio

Family:  Enzyme

Novelty:  0.00362108

p_int:  0.999998215

p_ni:  0.000001785

Score:  0.941

Data Source:  BioPlex,STRINGDB

MED20

Tbio

Family:  Enzyme

Novelty:  0.02039559

p_int:  0.999998208

p_ni:  0.000001792

Score:  0.919

Data Source:  BioPlex,STRINGDB

CCNC

Tbio

Novelty:  0.00585842

p_int:  0.999996511

p_ni:  0.000003489

Score:  0.997

Data Source:  BioPlex,STRINGDB

MED7

Tbio

Family:  Enzyme

Novelty:  0.04773947

p_int:  0.999986989

p_ni:  0.00001301

Score:  0.994

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (7)

Reactome (6)

KEGG (1)

Developmental Biology (R-HSA-1266738)

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1 – 5 of 6

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of lipids	740 targets	R-HSA-556833
Reactome	PPARA activates gene expression	117 targets	R-HSA-1989781
Reactome	Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	119 targets	R-HSA-400206

Name	Explore in Pharos	Explore in Source
Developmental Biology	1055 targets	R-HSA-1266738
Metabolism	2112 targets	R-HSA-1430728
Metabolism of lipids	740 targets	R-HSA-556833
PPARA activates gene expression	117 targets	R-HSA-1989781
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	119 targets	R-HSA-400206

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (3)

Functions (1)

Components (1)

Processes (1)

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10

1 – 1 of 1

GO Term	Evidence	Assigned by
transcription coregulator activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations ()

No disease associations found

GWAS Traits (12)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 12

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	2	1	2		67.4
pulse pressure measurement	EFO_0005763	1	1	1		45.2
appendicular lean mass	EFO_0004980	2	1	2		36.9
cutaneous melanoma	EFO_0000389	1	1	0	1.1	36.5
self reported educational attainment	EFO_0004784	1	1	1		33.1

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 12

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	2		67.4
pulse pressure measurement	EFO_0005763	1		45.2
appendicular lean mass	EFO_0004980	2		36.9
cutaneous melanoma	EFO_0000389	0	1.1	36.5
self reported educational attainment	EFO_0004784	1		33.1

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Activator
Chromosomal rearrangement
Complete proteome
Disease mutation
Mental retardation
Nucleus
Phosphoprotein
Reference proteome
Repeat
Repressor

GWAS Trait Find Similar Targets

No Header	No Header
appendicular lean mass
body height
bone density
chronotype measurement
comparative body size at age 10, self-reported
cutaneous melanoma
hair color
heel bone mineral density
lymphocyte count
pulse pressure measurement

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	mediator complex subunit 13 like	VGNC:8467	452281
Macaque	mediator complex subunit 13 like		713867
Mouse	mediator complex subunit 13-like	MGI:2670178	76199
Rat	mediator complex subunit 13-like	RGD:1305884	360817
Dog	mediator complex subunit 13 like	VGNC:43123	477496

Species	Name	OMA	EggNOG	Inparanoid
Chimp	mediator complex subunit 13 like
Macaque	mediator complex subunit 13 like
Mouse	mediator complex subunit 13-like
Rat	mediator complex subunit 13-like
Dog	mediator complex subunit 13 like

Publication Statistics

PubMed Score 30.68

PubMed score by year

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PubTator Score 19.06

PubTator score by year

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Related Publications

Text Mined References (21)

GeneRif Annotations (13)

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10

0 of 0

PMID	Year	Title