MED13L
Mediator of RNA polymerase II transcription subunit 13-like
Protein Summary
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. The protein encoded by this gene is a subunit of the Mediator complex, a large complex of proteins that functions as a transcriptional coactivator for most RNA polymerase II-transcribed genes. The encoded protein is involved in early development of the heart and brain. Defects in this gene are a cause of transposition of the great arteries, dextro-looped (DTGA).[prov ...more
- ENST00000281928
- ENSP00000281928
- ENSG00000123066
- KIAA1025
- PROSIT240
- THRAP2
- TRAP240L
- MRFACD
- THRAP2
- TRAP240L
- PROSIT240
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.91 | ||
transcription factor binding site profile | 0.9 | ||
transcription factor perturbation | 0.88 | ||
drug perturbation | 0.87 | ||
microRNA | 0.84 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 27.62 (req: < 5)
Gene RIFs: 13 (req: <= 3)
Antibodies: 83 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 27.62 (req: >= 5)
Gene RIFs: 13 (req: > 3)
Antibodies: 83 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (11)
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 2 | 1 | 2 | 82.7 | |||||
self reported educational attainment | 1 | 1 | 1 | 63.6 | |||||
pulse pressure measurement | 1 | 1 | 1 | 33.7 | |||||
1 | 1 | 0 | 1.1 | 27.2 | |||||
bone density | 1 | 1 | 1 | 19.9 | |||||
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
heel bone mineral density | 2 | 82.7 | |||||
self reported educational attainment | 1 | 63.6 | |||||
pulse pressure measurement | 1 | 33.7 | |||||
0 | 1.1 | 27.2 | |||||
bone density | 1 | 19.9 | |||||
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | mediator complex subunit 13 like | VGNC:8467 | 452281 | |||||
Macaque | mediator complex subunit 13 like | 713867 | ||||||
Mouse | MGI:2670178 | 76199 | ||||||
Rat | RGD:1305884 | 360817 | ||||||
Dog | mediator complex subunit 13 like | VGNC:43123 | 477496 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | mediator complex subunit 13 like | |||||
Macaque | mediator complex subunit 13 like | |||||
Mouse | ||||||
Rat | ||||||
Dog | mediator complex subunit 13 like | |||||
Pathways (7)
Reactome (6)
KEGG (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 6
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Developmental Biology | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of lipids | ||||
Reactome | PPARA activates gene expression | ||||
Reactome | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Developmental Biology | ||||
Metabolism | ||||
Metabolism of lipids | ||||
PPARA activates gene expression | ||||
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||||
Gene Ontology Terms (3)
Functions (1)
Components (1)
Processes (1)
Items per page:
10
1 – 1 of 1
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Protein-Protein Interactions (121)
1 – 10 of 121
MED19
Family: Enzyme
Novelty: 0.03926689
p_int: 0.999999931
p_ni: 6.8e-8
p_wrong: 1e-9
Score: 0.991
Data Source: BioPlex,STRINGDB
MED21
Family: Enzyme
Novelty: 0.06996616
p_int: 0.9999999
p_ni: 9.9e-8
p_wrong: 1e-9
Score: 0.986
Data Source: BioPlex,STRINGDB
MED17
Family: Enzyme
Novelty: 0.02984503
p_int: 0.999999757
p_ni: 2.43e-7
Score: 0.953
Data Source: BioPlex,STRINGDB
MED18
Family: Enzyme
Novelty: 0.04066825
p_int: 0.999999703
p_ni: 2.96e-7
p_wrong: 1e-9
Score: 0.988
Data Source: BioPlex,STRINGDB
MED10
Family: Enzyme
Novelty: 0.02988632
p_int: 0.999998804
p_ni: 0.000001196
Score: 0.995
Data Source: BioPlex,STRINGDB
MED1
Family: Enzyme
Novelty: 0.00852082
p_int: 0.999998393
p_ni: 0.000001607
Score: 0.989
Data Source: BioPlex,STRINGDB
MED28
Family: Enzyme
Novelty: 0.00362108
p_int: 0.999998215
p_ni: 0.000001785
Score: 0.941
Data Source: BioPlex,STRINGDB
MED20
Family: Enzyme
Novelty: 0.02039559
p_int: 0.999998208
p_ni: 0.000001792
Score: 0.919
Data Source: BioPlex,STRINGDB
CCNC
Novelty: 0.00585842
p_int: 0.999996511
p_ni: 0.000003489
Score: 0.997
Data Source: BioPlex,STRINGDB
MED7
Family: Enzyme
Novelty: 0.04773947
p_int: 0.999986989
p_ni: 0.00001301
Score: 0.994
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score 27.62
PubMed score by year
PubTator Score 19.06
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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