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Tbio
CENPU
Centromere protein U

Protein Summary
Description
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression. The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. All active centromeres are characterized by the presence of long arrays of nucleosomes in which CENPA (MIM 117139) replaces histone H3 (see MIM 601128). MLF1IP, or CENPU, is an additional factor required for centromere ass ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000281453
  • ENSP00000281453
  • ENSG00000151725

Symbol
  • ICEN24
  • KLIP1
  • MLF1IP
  • PBIP1
  • KLIP1
  • PBIP1
  • CENP50
  • MLF1IP
  • CENPU50
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
transcription factor binding site profile
0.85
histone modification site profile
0.8
gene perturbation
0.7
PubMedID
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.43   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 282   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.43   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 282   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.4
41.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.4
41.1
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
centromere protein U
VGNC:577
461630
Macaque
centromere protein U
696925
Mouse
MGI:1919126
71876
Rat
RGD:1562566
306464
Dog
centromere protein U
VGNC:39113
607799
Species
Name
OMA
EggNOG
Inparanoid
Chimp
centromere protein U
Macaque
centromere protein U
Mouse
Rat
Dog
centromere protein U
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q71F23-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (20)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Gene Ontology Terms (8)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (277)
1 – 10 of 277
CENPP
Tbio
Novelty: 0.29282259
p_int: 1
Score: 0.997
Data Source: BioPlex,STRINGDB
ITGB3BP
Tbio
Novelty: 0.06162186
p_int: 0.999999999
p_ni: 1e-9
Score: 0.998
Data Source: BioPlex,STRINGDB
CENPO
Tbio
Novelty: 0.12059767
p_int: 0.999999981
p_ni: 1.9e-8
Score: 0.998
Data Source: BioPlex,STRINGDB
NUP62
Tbio
Novelty: 0.01432724
p_int: 0.999958122
p_ni: 0.000041875
p_wrong: 3e-9
Data Source: BioPlex
CENPQ
Tbio
Novelty: 0.19972678
p_int: 0.999913743
p_ni: 0.000086256
p_wrong: 1e-9
Score: 0.997
Data Source: BioPlex,STRINGDB
CENPI
Tbio
Novelty: 0.01938121
p_int: 0.99596167
p_ni: 0.003982227
p_wrong: 0.000056103
Score: 0.997
Data Source: BioPlex,STRINGDB
RPL18A
Tbio
Novelty: 0.04612948
p_int: 0.992565351
p_ni: 0.007434649
Score: 0.23
Data Source: BioPlex,STRINGDB
DGCR8
Tbio
Novelty: 0.00271221
p_int: 0.991153966
p_ni: 0.008845965
p_wrong: 7e-8
Score: 0.313
Data Source: BioPlex,STRINGDB
RPL7A
Tbio
Novelty: 0.01674027
p_int: 0.990721691
p_ni: 0.009274
p_wrong: 0.000004309
Data Source: BioPlex
CENPC
Tbio
Novelty: 0.00638662
p_int: 0.989745057
p_ni: 0.010018295
p_wrong: 0.000236648
Score: 0.992
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  30.43

PubMed score by year
PubTator Score  16.6

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer