Tbio HIST2H3A Histone H3.2

Protein Summary

Description

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the telomeric copy. [provided by RefSeq, Aug 2015]

Uniprot Accession IDs

• Q71DI3
• A2BDF6
• A6NFS4
• Q6B053

Gene Name

• HIST2H3A

Ensembl ID

• ENST00000331491
• ENSP00000333277
• ENSG00000183598
• ENST00000369158
• ENSP00000358154
• ENSG00000203811
• ENST00000403683
• ENSP00000385479
• ENSG00000203852

Symbol

• H3
• H3.2
• H3/M
• H3F2
• H3FM
• H3FN

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.63
cell type or tissue	0.61
cell line	0.5
protein complex	0.42
transcription factor	0.32

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.68   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 165   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.68   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0