Tbio HIST2H3A Histone H3.2

Protein Summary

Description

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the telomeric copy. [provided by RefSeq, Aug 2015]

Uniprot Accession IDs

• Q71DI3
• A2BDF6
• A6NFS4
• Q6B053

Gene Name

• HIST2H3A

Ensembl ID

• ENST00000331491
• ENSP00000333277
• ENSG00000183598
• ENST00000369158
• ENSP00000358154
• ENSG00000203811
• ENST00000403683
• ENSP00000385479
• ENSG00000203852

Symbol

• H3
• H3.2
• H3/M
• H3F2
• H3FM
• H3FN

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.63
cell type or tissue	0.61
cell line	0.5
protein complex	0.42
transcription factor	0.32

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.94   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 165   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.94   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (20)

1 – 5 of 20

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (76)

Reactome (67)

KEGG (3)

PathwayCommons (3)

WikiPathways (3)

Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (R-HSA-5625886)

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Items per page:

5

1 – 5 of 67

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	36 targets	R-HSA-5625886
Reactome	Activation of HOX genes during differentiation	90 targets	R-HSA-5619507
Reactome	Activation of anterior HOX genes in hindbrain development during early embryogenesis	90 targets	R-HSA-5617472
Reactome	Amyloid fiber formation	79 targets	R-HSA-977225
Reactome	B-WICH complex positively regulates rRNA expression	61 targets	R-HSA-5250924

Name	Explore in Pharos	Explore in Source
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	36 targets	R-HSA-5625886
Activation of HOX genes during differentiation	90 targets	R-HSA-5619507
Activation of anterior HOX genes in hindbrain development during early embryogenesis	90 targets	R-HSA-5617472
Amyloid fiber formation	79 targets	R-HSA-977225
B-WICH complex positively regulates rRNA expression	61 targets	R-HSA-5250924

Gene Ontology Terms (16)

Functions (2)

Components (5)

Processes (9)

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
nucleosomal DNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
protein heterodimerization activity	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (188)

Explore Interacting Targets

1 – 10 of 188

• See Interactions on String-DB

HIST2H2BE

Tbio

Novelty: 0.00035412

Score: 0.986

Data Source: STRINGDB

HIST1H2BB

Tbio

Novelty: 0.87484449

Score: 0.98

Data Source: STRINGDB

HIST1H2BJ

Tbio

Novelty: 0.41650133

Score: 0.977

Data Source: STRINGDB

HIST1H2AG

Tbio

Novelty: 0.04547818

Score: 0.976

Data Source: STRINGDB

ASF1A

Tchem

Novelty: 0.02930331

Score: 0.975

Data Source: STRINGDB

H2AFJ

Tbio

Novelty: 0.6866485

Score: 0.971

Data Source: STRINGDB

HIST1H4A

Tbio

Novelty: 0.00536075

Score: 0.969

Data Source: Reactome,STRINGDB

CBX3

Tbio

Family: Epigenetic

Novelty: 0.0093209

Score: 0.966

Data Source: Reactome,STRINGDB

H2AFY

Tbio

Novelty: 0.0155084

Score: 0.965

Data Source: STRINGDB

H3F3A

Tbio

Novelty: 0.00644912

Score: 0.965

Data Source: Reactome,STRINGDB

Publication Statistics

PubMed Score  18.94

PubMed score by year

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PubTator Score  300.64

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQR

1-70

LVREIAQDFKTDLRFQSSAVMALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA

70-136

MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA

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Uniprot Keyword

3D-structure
Acetylation
ADP-ribosylation
Chromosome
Citrullination
Complete proteome
Direct protein sequencing
DNA-binding
Hydroxylation
Lipoprotein