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Tbio
HIST2H3A
Histone H3.2

Protein Summary
Description
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the hi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331491
  • ENSP00000333277
  • ENSG00000183598
  • ENST00000369158
  • ENSP00000358154
  • ENSG00000203811
  • ENST00000403683
  • ENSP00000385479
  • ENSG00000203852

Symbol
  • H3
  • H3.2
  • H3/M
  • H3F2
  • H3FM
  • H3FN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.63
cell type or tissue
0.61
cell line
0.5
protein complex
0.42
transcription factor
0.32


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.57   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 165   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.57   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (188)
HIST2H2BE
Tbio
Novelty:  0.00024381
Score:  0.986
Data Source:  STRINGDB
HIST1H2BB
Tbio
Novelty:  0.20192804
Score:  0.98
Data Source:  STRINGDB
HIST1H2BJ
Tbio
Novelty:  0.14308844
Score:  0.977
Data Source:  STRINGDB
HIST1H2AG
Tbio
Novelty:  0.03331195
Score:  0.976
Data Source:  STRINGDB
ASF1A
Tchem
Novelty:  0.02544466
Score:  0.975
Data Source:  STRINGDB
H2AFJ
Tbio
Novelty:  0.34726304
Score:  0.971
Data Source:  STRINGDB
HIST1H4A
Tchem
Novelty:  0.00279614
Score:  0.969
Data Source:  Reactome,STRINGDB
CBX3
Tbio
Family:  Epigenetic
Novelty:  0.00776486
Score:  0.966
Data Source:  Reactome,STRINGDB
H2AFY
Tbio
Novelty:  0.01150729
Score:  0.965
Data Source:  STRINGDB
H3F3A
Tbio
Novelty:  0.00508186
Score:  0.965
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (76)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (R-HSA-5625886)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 67
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Amyloid fiber formation
Reactome
B-WICH complex positively regulates rRNA expression
Name
Explore in Pharos
Explore in Source
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Amyloid fiber formation
B-WICH complex positively regulates rRNA expression
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (53)
Items per page:
1 – 5 of 53
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
3
4
8
96.5
BMI-adjusted hip circumference
3
4
8
96.5
BMI-adjusted waist circumference
7
3
15
88.8
BMI-adjusted waist circumference
7
3
15
88.8
sex hormone-binding globulin measurement
5
3
5
87.9
Items per page:
1 – 5 of 53
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
8
96.5
BMI-adjusted hip circumference
8
96.5
BMI-adjusted waist circumference
15
88.8
BMI-adjusted waist circumference
15
88.8
sex hormone-binding globulin measurement
5
87.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 30.57
PubMed score by year
PubTator Score 300.64
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title