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Tbio
HIST2H3A
Histone H3.2

Protein Summary
Description
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the hi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331491
  • ENSP00000333277
  • ENSG00000183598
  • ENST00000369158
  • ENSP00000358154
  • ENSG00000203811
  • ENST00000403683
  • ENSP00000385479
  • ENSG00000203852

Symbol
  • H3
  • H3.2
  • H3/M
  • H3F2
  • H3FM
  • H3FN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.63
cell type or tissue
0.61
cell line
0.5
protein complex
0.42
transcription factor
0.32


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.94   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 165   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.94   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (20)
1 – 5 of 20
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (76)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (R-HSA-5625886)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 67
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Amyloid fiber formation
Reactome
B-WICH complex positively regulates rRNA expression
Name
Explore in Pharos
Explore in Source
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Amyloid fiber formation
B-WICH complex positively regulates rRNA expression
Gene Ontology Terms (16)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (188)
1 – 10 of 188
HIST2H2BE
Tbio
Novelty: 0.00035412
Score: 0.986
Data Source: STRINGDB
HIST1H2BB
Tbio
Novelty: 0.87484449
Score: 0.98
Data Source: STRINGDB
HIST1H2BJ
Tbio
Novelty: 0.41650133
Score: 0.977
Data Source: STRINGDB
HIST1H2AG
Tbio
Novelty: 0.04547818
Score: 0.976
Data Source: STRINGDB
ASF1A
Tchem
Novelty: 0.02930331
Score: 0.975
Data Source: STRINGDB
H2AFJ
Tbio
Novelty: 0.6866485
Score: 0.971
Data Source: STRINGDB
HIST1H4A
Tbio
Novelty: 0.00536075
Score: 0.969
Data Source: Reactome,STRINGDB
CBX3
Tbio
Family: Epigenetic
Novelty: 0.0093209
Score: 0.966
Data Source: Reactome,STRINGDB
H2AFY
Tbio
Novelty: 0.0155084
Score: 0.965
Data Source: STRINGDB
H3F3A
Tbio
Novelty: 0.00644912
Score: 0.965
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  18.94

PubMed score by year
PubTator Score  300.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer