Protein Summary
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the hi ...more
- ENST00000331491
- ENSP00000333277
- ENSG00000183598
- ENST00000369158
- ENSP00000358154
- ENSG00000203811
- ENST00000403683
- ENSP00000385479
- ENSG00000203852
- H3
- H3.2
- H3/M
- H3F2
- H3FM
- H3FN
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
cellular component | 0.63 | ||
cell type or tissue | 0.61 | ||
cell line | 0.5 | ||
protein complex | 0.42 | ||
transcription factor | 0.32 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 18.94 (req: < 5)
Gene RIFs: 22 (req: <= 3)
Antibodies: 165 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 18.94 (req: >= 5)
Gene RIFs: 22 (req: > 3)
Antibodies: 165 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Data Bank (20)
1 – 5 of 20
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
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PDB Structure Id | M.W. | Resolution | Pub Year |
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Pathways (76)
Reactome (67)
KEGG (3)
PathwayCommons (3)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 67
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||||
Reactome | Activation of HOX genes during differentiation | ||||
Reactome | Activation of anterior HOX genes in hindbrain development during early embryogenesis | ||||
Reactome | Amyloid fiber formation | ||||
Reactome | B-WICH complex positively regulates rRNA expression | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||||
Activation of HOX genes during differentiation | ||||
Activation of anterior HOX genes in hindbrain development during early embryogenesis | ||||
Amyloid fiber formation | ||||
B-WICH complex positively regulates rRNA expression | ||||
Gene Ontology Terms (16)
Functions (2)
Components (5)
Processes (9)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (188)
1 – 10 of 188
HIST2H2BE
Novelty: 0.00035412
Score: 0.986
Data Source: STRINGDB
HIST1H2BB
Novelty: 0.87484449
Score: 0.98
Data Source: STRINGDB
HIST1H2BJ
Novelty: 0.41650133
Score: 0.977
Data Source: STRINGDB
HIST1H2AG
Novelty: 0.04547818
Score: 0.976
Data Source: STRINGDB
ASF1A
Novelty: 0.02930331
Score: 0.975
Data Source: STRINGDB
H2AFJ
Novelty: 0.6866485
Score: 0.971
Data Source: STRINGDB
HIST1H4A
Novelty: 0.00536075
Score: 0.969
Data Source: Reactome,STRINGDB
CBX3
Family: Epigenetic
Novelty: 0.0093209
Score: 0.966
Data Source: Reactome,STRINGDB
H2AFY
Novelty: 0.0155084
Score: 0.965
Data Source: STRINGDB
H3F3A
Novelty: 0.00644912
Score: 0.965
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score 18.94
PubMed score by year
PubTator Score 300.64
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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