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Tchem
HTR3D
5-hydroxytryptamine receptor 3D

Protein Summary
Description
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel. The protein encoded this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit D of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a mitogen and a hormone. This hormone has been linked to neuropsychiatric disorders, including anxiety, depression, and migraine. Serotonin receptors causes fast and depolarizing responses in neurons following activation. The genes encoding subunits C, D and E of this type 3 receptor form a cluster on chromosome 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382489
  • ENSP00000371929
  • ENSG00000186090
  • ENST00000428798
  • ENSP00000405409
  • ENST00000453435
  • ENSP00000389268

Symbol
  • 5HT3D
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.76
phenotype
0.62
protein domain
0.58
cell line
0.47
disease
0.47


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.54   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 44   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.54   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 44   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (27)
LRFN4
Tbio
Novelty:  0.12511571
p_int:  0.994287853
p_ni:  0.005696202
p_wrong:  0.000015945
Score:  0.189
Data Source:  BioPlex,STRINGDB
RSPRY1
Tdark
Novelty:  0.26883105
p_int:  0.900152427
p_ni:  0.099847562
p_wrong:  1.1e-8
Score:  0.159
Data Source:  BioPlex,STRINGDB
HSDL1
Tbio
Family:  Enzyme
Novelty:  0.24066595
p_int:  0.889729469
p_ni:  0.11027053
p_wrong:  2e-9
Score:  0.239
Data Source:  BioPlex,STRINGDB
HTR3A
Tclin
Family:  IC
Novelty:  0.00217443
Score:  0.944
Data Source:  Reactome,STRINGDB
RIC3
Tbio
Novelty:  0.0162412
Score:  0.558
Data Source:  STRINGDB
HTR5A
Tchem
Family:  GPCR
Novelty:  0.0160551
Score:  0.548
Data Source:  STRINGDB
HTR7
Tclin
Family:  GPCR
Novelty:  0.00169884
Score:  0.537
Data Source:  STRINGDB
ZACN
Tchem
Family:  IC
Novelty:  0.21891621
Score:  0.533
Data Source:  STRINGDB
SNCA
Tchem
Novelty:  0.00012042
Score:  0.501
Data Source:  STRINGDB
HTR1D
Tclin
Family:  GPCR
Novelty:  0.00240121
Score:  0.476
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Neuronal System (R-HSA-112316)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neuronal System
Reactome
Neurotransmitter receptors and postsynaptic signal transmission
Reactome
Transmission across Chemical Synapses
Name
Explore in Pharos
Explore in Source
Neuronal System
Neurotransmitter receptors and postsynaptic signal transmission
Transmission across Chemical Synapses
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
2
2
90.9
mean platelet volume
2
2
2
83.7
neutrophil count
2
2
2
82
myeloid white cell count
1
1
1
73.6
leukocyte count
1
1
1
70.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
90.9
mean platelet volume
2
83.7
neutrophil count
2
82
myeloid white cell count
1
73.6
leukocyte count
1
70.8
Find similar targets by:
Orthologs
No orthologs found
Publication Statistics
PubMed Score 6.54
PubMed score by year
PubTator Score 4.11
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title