Tchem HTR3D 5-hydroxytryptamine receptor 3D

Protein Summary

Description

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel. The protein encoded this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit D of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a mitogen and a hormone. This hormone has been linked to neuropsychiatric disorders, including anxiety, depression, and migraine. Serotonin receptors causes fast and depolarizing responses in neurons following activation. The genes encoding subunits C, D and E of this type 3 receptor form a cluster on chromosome 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]

Uniprot Accession IDs

• Q70Z44
• C9J2I6
• J3QT78
• Q495N5
• Q495N6
• Q7Z6B3
• 5-HT3-D

Gene Name

• HTR3D

Ensembl ID

• ENST00000382489
• ENSP00000371929
• ENSG00000186090
• ENST00000428798
• ENSP00000405409
• ENST00000453435
• ENSP00000389268

Symbol

• 5HT3D

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.76
phenotype	0.62
protein domain	0.58
cell line	0.47
disease	0.47

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Ligand-gated Ion Channel / Acetylcholine Receptor / 5-hydroxytryptamine Receptor 3d

Protein / Transporter / Ion Channel / Ligand-gated Ion Channel / Gaba Receptor / 5-hydroxytryptamine Receptor 3d

Protein / Receptor / Ligand-gated Ion Channel / Acetylcholine Receptor / 5-hydroxytryptamine Receptor 3d

Protein / Receptor / Ligand-gated Ion Channel / Gaba Receptor / 5-hydroxytryptamine Receptor 3d

DTO Classes

Protein / Ion Channel / Neurotransmitter Receptor, Cys Loop, Ligand-gated Ion Channel (Lic) Family / 5-hydroxytryptamine Receptor Subfamily / 5-ht3 Receptor Sub-subfamily / 5-hydroxytryptamine Receptor 3d

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.04   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 44   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.04   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 44   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2