Protein Summary
Involved in the regulation of neurogenesis. Negatively regulates neurite outgrowth (PubMed:17389905). Involved in the morphogenesis of basket cells in the somatosensory cortex during embryogenesis. Involved in the positive regulation of oligodendrocyte differentiation during postnatal growth. Involved in dendritic arborization, morphogenesis of spine density dendrite, and establishment of postsynaptic dendrite density in cortical pyramidal neurons (By similarity). Involved in homologous recombination (HR) repair pathway. Required for proper resolution of DNA double-strand breaks (DSBs) by HR. Is required for recovery of stalled replication forks, and directly contributes to genomic stability. Interacts with PARP1 and mediates MRE11-dependent DNA end resection during replication fork recovery (PubMed:23966166). Contributes to genomic stability by preventing telomere dysfunction (PubMed:23776040). This gene encodes several isoforms which have different expression patterns and functions. ...more
- ENST00000395254
- ENSP00000378674
- ENSG00000138311
- ENST00000395255
- ENSP00000378675
- ENST00000410046
- ENSP00000387091
- DBZ
- KIAA0844
- UAN
- Su48
- ZNF365D
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.85 | ||
kinase perturbation | 0.76 | ||
trait | 0.75 | ||
transcription factor perturbation | 0.74 | ||
histone modification site profile | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 32.74 (req: < 5)
Gene RIFs: 15 (req: <= 3)
Antibodies: 367 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 32.74 (req: >= 5)
Gene RIFs: 15 (req: > 3)
Antibodies: 367 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (48)
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (2)
Components (3)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (17)
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
6 | 3 | 0 | 1.2 | 85.1 | |||||
mammographic density measurement | 3 | 2 | 6 | 67.6 | |||||
mammographic density percentage | 1 | 1 | 2 | 64.4 | |||||
breast size | 1 | 1 | 2 | 64 | |||||
Thyroid preparation use measurement | 1 | 1 | 2 | 64 | |||||
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.2 | 85.1 | |||||
mammographic density measurement | 6 | 67.6 | |||||
mammographic density percentage | 2 | 64.4 | |||||
breast size | 2 | 64 | |||||
Thyroid preparation use measurement | 2 | 64 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | zinc finger protein 365 | VGNC:12557 | 466081 | |||||
Macaque | zinc finger protein 365 | 698386 | ||||||
Mouse | MGI:2143676 | 216049 | ||||||
Rat | RGD:1565986 | 499425 | ||||||
Dog | zinc finger protein 365 | VGNC:48710 | 100855461 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | zinc finger protein 365 | |||||
Macaque | zinc finger protein 365 | |||||
Mouse | ||||||
Rat | ||||||
Dog | zinc finger protein 365 | |||||
Publication Statistics
PubMed Score 32.74
PubMed score by year
PubTator Score 19.58
PubTator score by year
Related Publications
Text Mined References (44)
GeneRif Annotations (15)
Items per page:
0 of 0
PMID | Year | Title |
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