Tbio Q70YC5 Protein ZNF365

Protein Summary

Description

Involved in the regulation of neurogenesis. Negatively regulates neurite outgrowth (PubMed:17389905). Involved in the morphogenesis of basket cells in the somatosensory cortex during embryogenesis. Involved in the positive regulation of oligodendrocyte differentiation during postnatal growth. Involved in dendritic arborization, morphogenesis of spine density dendrite, and establishment of postsynaptic dendrite density in cortical pyramidal neurons (By similarity). Involved in homologous recombination (HR) repair pathway. Required for proper resolution of DNA double-strand breaks (DSBs) by HR. Is required for recovery of stalled replication forks, and directly contributes to genomic stability. Interacts with PARP1 and mediates MRE11-dependent DNA end resection during replication fork recovery (PubMed:23966166). Contributes to genomic stability by preventing telomere dysfunction (PubMed:23776040). This gene encodes several isoforms which have different expression patterns and functions. Mutation in this gene is associated with uric acid nephrolithiasis (UAN). Alternatively spliced variants, encoding distinct proteins, have been identified. [provided by RefSeq, May 2010]

Uniprot Accession IDs

• Q70YC5
• A8K0F0
• O94930
• Q05D75
• Q5HYE6
• Q68SG8
• Q6NSK2
• Q6P9D4
• Q70YC6
• Q70YC7

Gene Name

• ZNF365

Ensembl ID

• ENST00000395254
• ENSP00000378674
• ENSG00000138311
• ENST00000395255
• ENSP00000378675
• ENST00000410046
• ENSP00000387091

Symbol

• DBZ
• KIAA0844
• UAN
• Su48
• ZNF365D

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.85
kinase perturbation	0.76
trait	0.75
transcription factor perturbation	0.74
histone modification site profile	0.73

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.38   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 367   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.38   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 367   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0