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Tbio
Q70YC5
Protein ZNF365

Protein Summary
Description
Involved in the regulation of neurogenesis. Negatively regulates neurite outgrowth (PubMed:17389905). Involved in the morphogenesis of basket cells in the somatosensory cortex during embryogenesis. Involved in the positive regulation of oligodendrocyte differentiation during postnatal growth. Involved in dendritic arborization, morphogenesis of spine density dendrite, and establishment of postsynaptic dendrite density in cortical pyramidal neurons (By similarity). Involved in homologous recombination (HR) repair pathway. Required for proper resolution of DNA double-strand breaks (DSBs) by HR. Is required for recovery of stalled replication forks, and directly contributes to genomic stability. Interacts with PARP1 and mediates MRE11-dependent DNA end resection during replication fork recovery (PubMed:23966166). Contributes to genomic stability by preventing telomere dysfunction (PubMed:23776040). This gene encodes several isoforms which have different expression patterns and functions. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000395254
  • ENSP00000378674
  • ENSG00000138311
  • ENST00000395255
  • ENSP00000378675
  • ENST00000410046
  • ENSP00000387091

Symbol
  • DBZ
  • KIAA0844
  • UAN
  • Su48
  • ZNF365D
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.85
kinase perturbation
0.76
trait
0.75
transcription factor perturbation
0.74
histone modification site profile
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.74   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 367   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.74   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 367   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (48)
DISC1
Tbio
Novelty:  0.00183442
Score:  0.75
Data Source:  STRINGDB
TNFSF4
Tbio
Novelty:  0.00308925
Score:  0.662
Data Source:  STRINGDB
LSP1
Tbio
Novelty:  0.00889927
Score:  0.63
Data Source:  STRINGDB
CTSH
Tchem
Family:  Enzyme
Novelty:  0.00336694
Score:  0.619
Data Source:  STRINGDB
NOTCH1
Tchem
Novelty:  0.00012547
Score:  0.586
Data Source:  STRINGDB
ZNF684
Tdark
Family:  TF
Novelty:  7.06924999
Score:  0.576
Data Source:  STRINGDB
TOX3
Tbio
Family:  TF
Novelty:  0.01573159
Score:  0.575
Data Source:  STRINGDB
SLC22A12
Tclin
Family:  Transporter
Novelty:  0.00318081
Score:  0.574
Data Source:  STRINGDB
OLFM4
Tbio
Novelty:  0.01048505
Score:  0.568
Data Source:  STRINGDB
NDEL1
Tbio
Novelty:  0.01241819
Score:  0.561
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
3
0
1.2
85.1
mammographic density measurement
3
2
6
67.6
mammographic density percentage
1
1
2
64.4
breast size
1
1
2
64
Thyroid preparation use measurement
1
1
2
64
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
85.1
mammographic density measurement
6
67.6
mammographic density percentage
2
64.4
breast size
2
64
Thyroid preparation use measurement
2
64
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 365
VGNC:12557
466081
Macaque
zinc finger protein 365
698386
Mouse
MGI:2143676
216049
Rat
RGD:1565986
499425
Dog
zinc finger protein 365
VGNC:48710
100855461
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 365
Macaque
zinc finger protein 365
Mouse
Rat
Dog
zinc finger protein 365
Publication Statistics
PubMed Score 32.74
PubMed score by year
PubTator Score 19.58
PubTator score by year
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Related Publications
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PMID
Year
Title