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Tdark
CHSY3
Chondroitin sulfate synthase 3

Protein Summary
Description
Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Specific activity is much reduced compared to CHSY1. CSS3 is a glycosyltransferase that has both glucuronyltransferase and N-acetylgalactosaminyltransferase activities (Yada et al., 2003 [PubMed 12907687]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305031
  • ENSP00000302629
  • ENSG00000198108

Symbol
  • CHSY2
  • CSS3
  • CSS3
  • CHSY2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.92
histone modification site profile
0.73
phenotype
0.72
gene perturbation
0.65
cellular component
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.22   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 99   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.22   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mosquito bite reaction itch intensity measurement
1
1
1
4.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mosquito bite reaction itch intensity measurement
1
4.9
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chondroitin sulfate synthase 3
VGNC:3951
471623
Macaque
chondroitin sulfate synthase 3
705715
Mouse
MGI:1926173
78923
Cow
chondroitin sulfate synthase 3
VGNC:27351
528149
Anole lizard
chondroitin sulfate synthase 3
100556433
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chondroitin sulfate synthase 3
Macaque
chondroitin sulfate synthase 3
Mouse
Cow
chondroitin sulfate synthase 3
Anole lizard
chondroitin sulfate synthase 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q70JA7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Chondroitin sulfate biosynthesis (R-HSA-2022870)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chondroitin sulfate biosynthesis
Reactome
Chondroitin sulfate/dermatan sulfate metabolism
Reactome
Glycosaminoglycan metabolism
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Chondroitin sulfate biosynthesis
Chondroitin sulfate/dermatan sulfate metabolism
Glycosaminoglycan metabolism
Metabolism
Metabolism of carbohydrates
Protein-Protein Interactions (57)
1 – 10 of 57
CHSY1
Tbio
Family: Enzyme
Novelty: 0.03515909
p_int: 0.999999927
p_ni: 7.3e-8
p_wrong: 1e-9
Score: 0.946
Data Source: BioPlex,STRINGDB
PLAUR
Tchem
Family: Enzyme
Novelty: 0.00087642
p_int: 0.995070045
p_ni: 0.004929918
p_wrong: 3.7e-8
Data Source: BioPlex
LCN6
Tbio
Novelty: 0.11406686
p_int: 0.994897916
p_ni: 0.005100764
p_wrong: 0.00000132
Data Source: BioPlex
SCGB2A2
Tbio
Novelty: 0.01594053
p_int: 0.99128363
p_ni: 0.008716348
p_wrong: 2.2e-8
Data Source: BioPlex
OS9
Tbio
Novelty: 0.01490339
p_int: 0.989979436
p_ni: 0.010018875
p_wrong: 0.000001689
Data Source: BioPlex
LRFN4
Tbio
Novelty: 0.12511571
p_int: 0.980542548
p_ni: 0.019454773
p_wrong: 0.000002679
Data Source: BioPlex
SIAE
Tbio
Family: Enzyme
Novelty: 0.01138067
p_int: 0.97739611
p_ni: 0.02260389
p_wrong: 1e-9
Data Source: BioPlex
GOLPH3
Tbio
Novelty: 0.00020234
p_int: 0.972617887
p_ni: 0.023161028
p_wrong: 0.004221085
Data Source: BioPlex
GDPD5
Tbio
Family: Enzyme
Novelty: 0.05871733
p_int: 0.965840152
p_ni: 0.034158597
p_wrong: 0.000001252
Data Source: BioPlex
ISLR
Tbio
Novelty: 0.02936208
p_int: 0.962357969
p_ni: 0.03764203
p_wrong: 1e-9
Score: 0.172
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  3.22

PubMed score by year
PubTator Score  15.95

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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