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Tbio
UNC13D
Protein unc-13 homolog D

Protein Summary
Description
Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. This gene encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder. [provided by RefSeq, Jul ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000207549
  • ENSP00000207549
  • ENSG00000092929
  • ENST00000412096
  • ENSP00000388093

Symbol
  • FHL3
  • HLH3
  • HPLH3
  • Munc13-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.83
transcription factor binding site profile
0.82
transcription factor
0.79
cellular component
0.66
tissue sample
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 149.79   (req: < 5)
Gene RIFs: 48   (req: <= 3)
Antibodies: 195   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 149.79   (req: >= 5)
Gene RIFs: 48   (req: > 3)
Antibodies: 195   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (139)
RAB27A
Tchem
Family:  Enzyme
Novelty:  0.00369416
Score:  0.952
Data Source:  STRINGDB
STX11
Tbio
Novelty:  0.01670743
Score:  0.933
Data Source:  STRINGDB
CAP1
Tbio
Family:  Enzyme
Novelty:  0.0333464
Score:  0.919
Data Source:  STRINGDB
MPO
Tchem
Family:  Enzyme
Novelty:  0.00020698
Score:  0.913
Data Source:  STRINGDB
ADA2
Tbio
Family:  Enzyme
Novelty:  0.01077582
Score:  0.91
Data Source:  STRINGDB
ELANE
Tclin
Family:  Enzyme
Novelty:  0.00026112
Score:  0.908
Data Source:  STRINGDB
LYZ
Tbio
Family:  Enzyme
Novelty:  0.00151342
Score:  0.908
Data Source:  STRINGDB
ARHGAP45
Tbio
Novelty:  0.13518861
Score:  0.906
Data Source:  STRINGDB
STXBP2
Tbio
Novelty:  0.01896992
Score:  0.906
Data Source:  STRINGDB
PLAC8
Tbio
Novelty:  0.00882894
Score:  0.906
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

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Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (21)
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Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (27)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
white matter hyperintensity measurement
9
5
8
12.5
99.2
low density lipoprotein cholesterol measurement
6
4
6
96.3
sex hormone-binding globulin measurement
8
3
7
6.8
92.3
eosinophil count
3
2
3
69.4
brain volume measurement
1
1
1
68.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
white matter hyperintensity measurement
8
12.5
99.2
low density lipoprotein cholesterol measurement
6
96.3
sex hormone-binding globulin measurement
7
6.8
92.3
eosinophil count
3
69.4
brain volume measurement
1
68.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
unc-13 homolog D
VGNC:9764
454891
Macaque
unc-13 homolog D
704431
Mouse
MGI:1917700
70450
Rat
RGD:628593
192177
Dog
unc-13 homolog D
VGNC:48136
483319
Species
Name
OMA
EggNOG
Inparanoid
Chimp
unc-13 homolog D
Macaque
unc-13 homolog D
Mouse
Rat
Dog
unc-13 homolog D
Publication Statistics
PubMed Score 149.79
PubMed score by year
PubTator Score 98.32
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title