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Tbio
SLC25A26
S-adenosylmethionine mitochondrial carrier protein

Protein Summary
Description
Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. Specifically mediates the transport of S-adenosylmethionine (SAM) into the mitochondria. This gene is a member of the mitochondrial carrier family which includes nuclear-encoded transporters localized on the inner mitochondrial membranes. Members of the family transport important small molecules across the mitochondrial inner membrane. This protein is involved in the transport of S-adenosylmethionine (SAM) into the mitochondria. Mutations in this gene are associated with combined oxidative phosphorylation deficiency 28. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336733
  • ENSP00000336801
  • ENSG00000144741
  • ENST00000354883
  • ENSP00000346955
  • ENST00000632575
  • ENSP00000488865
  • ENSG00000282739
  • ENST00000633701
  • ENSP00000488659

Symbol
  • SAMC
  • SAMC
  • COXPD28
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.92
tissue sample
0.63
transcription factor perturbation
0.61
transcription factor
0.59
cellular component
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.3   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 78   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.3   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 78   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
78.6
hemoglobin measurement
1
1
1
61.2
1
2
0
1.1
60.1
heel bone mineral density
1
1
1
48.9
electrocardiography
1
1
3
19.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
78.6
hemoglobin measurement
1
61.2
0
1.1
60.1
heel bone mineral density
1
48.9
electrocardiography
3
19.1
Pathways (3)
SLC-mediated transmembrane transport (R-HSA-425407)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of inorganic cations/anions and amino acids/oligopeptides
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
SLC-mediated transmembrane transport
Transport of inorganic cations/anions and amino acids/oligopeptides
Transport of small molecules
Protein-Protein Interactions (28)
1 – 10 of 28
SPACA1
Tbio
Novelty: 0.07415851
p_int: 0.769372979
p_ni: 0.230347177
p_wrong: 0.000279844
Score: 0.224
Data Source: BioPlex,STRINGDB
CDC5L
Tbio
Family: TF
Novelty: 0.00663599
Score: 0.98
Data Source: STRINGDB
THOC7
Tbio
Novelty: 0.16971494
Score: 0.745
Data Source: STRINGDB
PPHLN1
Tbio
Novelty: 0.21311177
Score: 0.713
Data Source: STRINGDB
PSMD6
Tbio
Family: Enzyme
Novelty: 0.04419339
Score: 0.69
Data Source: STRINGDB
PRICKLE2
Tbio
Novelty: 0.04809589
Score: 0.594
Data Source: STRINGDB
ATXN7
Tbio
Novelty: 0.00323014
Score: 0.564
Data Source: STRINGDB
ADAMTS9
Tbio
Family: Enzyme
Novelty: 0.01447959
Score: 0.552
Data Source: STRINGDB
LRIG1
Tbio
Novelty: 0.01078663
Score: 0.526
Data Source: STRINGDB
SLC16A14
Tbio
Family: Transporter
Novelty: 0.0669267
Score: 0.524
Data Source: STRINGDB
Publication Statistics
PubMed Score  10.30

PubMed score by year
PubTator Score  27.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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