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Tbio
RAPH1
Ras-associated and pleckstrin homology domains-containing protein 1

Protein Summary
Description
Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion. This gene encodes a protein that belongs to the Mig10/Rap1-interacting adaptor molecule/Lamellipodin family of adapter proteins, which function in cell migration. Members of this family contain pleckstrin-homology domains, Ras-association domains, and proline-rich C-termini. The protein encoded by this gene regulates actin dynamics through interaction with Ena/Vasodilator proteins as well as direct binding to filamentous actin to regulate actin network assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308091
  • ENSP00000311293
  • ENSG00000173166
  • ENST00000319170
  • ENSP00000316543
  • ENST00000418114
  • ENSP00000396711
  • ENST00000419464
  • ENSP00000390578
  • ENST00000423104
  • ENSP00000397751
  • ENST00000439222
  • ENSP00000411138
  • ENST00000453034
  • ENSP00000406662

Symbol
  • ALS2CR18
  • ALS2CR9
  • KIAA1681
  • LPD
  • PREL2
  • RMO1
  • LPD
  • RMO1
  • PREL2
  • PREL-2
  • ALS2CR9
  • ALS2CR18
  • RalGDS/AF-6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.92
virus perturbation
0.76
cell line
0.75
cell type or tissue
0.73
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.44   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 66   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.44   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (66)
ABI2
Tbio
Novelty:  0.02324355
p_int:  0.999999998
p_ni:  2e-9
Score:  0.867
Data Source:  BioPlex,STRINGDB
NCK2
Tbio
Novelty:  0.02220251
p_int:  0.999999986
p_ni:  1.2e-8
p_wrong:  2e-9
Score:  0.602
Data Source:  BioPlex,STRINGDB
ARHGAP12
Tbio
Family:  Enzyme
Novelty:  0.12113722
p_int:  0.99992327
p_ni:  0.000075964
p_wrong:  7.66e-7
Data Source:  BioPlex
DNM3
Tbio
Novelty:  0.02365643
p_int:  0.97891189
p_ni:  0.017336337
p_wrong:  0.003751774
Score:  0.213
Data Source:  BioPlex,STRINGDB
VASP
Tbio
Novelty:  0.00041984
Score:  0.9
Data Source:  STRINGDB
ENAH
Tbio
Novelty:  0.02329247
Score:  0.827
Data Source:  STRINGDB
TLN1
Tbio
Novelty:  0.00803981
Score:  0.808
Data Source:  STRINGDB
TLN2
Tbio
Novelty:  0.0284423
Score:  0.774
Data Source:  STRINGDB
ABI1
Tbio
Novelty:  0.00796638
Score:  0.665
Data Source:  STRINGDB
PGK1
Tchem
Family:  Kinase
Novelty:  0.00113494
Score:  0.642
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
butyrylcholinesterase measurement
1
1
1
69.8
apolipoprotein B measurement
1
1
1
46.1
hematocrit
1
1
1
39.6
hemoglobin measurement
1
1
1
36.9
urinary albumin to creatinine ratio
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
butyrylcholinesterase measurement
1
69.8
apolipoprotein B measurement
1
46.1
hematocrit
1
39.6
hemoglobin measurement
1
36.9
urinary albumin to creatinine ratio
1
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
VGNC:14348
459893
Macaque
Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
705065
Rat
RGD:1308387
363239
Dog
Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 [Source:HGNC Symbol;Acc:HGNC:14436]
Cow
Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
VGNC:54621
523153
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
Macaque
Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
Rat
Dog
Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 [Source:HGNC Symbol;Acc:HGNC:14436]
Cow
Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
Publication Statistics
PubMed Score 41.44
PubMed score by year
PubTator Score 54.30
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title