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Tbio
RAPH1
Ras-associated and pleckstrin homology domains-containing protein 1

Protein Summary
Description
Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion. This gene encodes a protein that belongs to the Mig10/Rap1-interacting adaptor molecule/Lamellipodin family of adapter proteins, which function in cell migration. Members of this family contain pleckstrin-homology domains, Ras-association domains, and proline-rich C-termini. The protein encoded by this gene regulates actin dynamics through interaction with Ena/Vasodilator proteins as well as direct binding to filamentous actin to regulate actin network assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308091
  • ENSP00000311293
  • ENSG00000173166
  • ENST00000319170
  • ENSP00000316543
  • ENST00000418114
  • ENSP00000396711
  • ENST00000419464
  • ENSP00000390578
  • ENST00000423104
  • ENSP00000397751
  • ENST00000439222
  • ENSP00000411138
  • ENST00000453034
  • ENSP00000406662

Symbol
  • ALS2CR18
  • ALS2CR9
  • KIAA1681
  • LPD
  • PREL2
  • RMO1
  • LPD
  • RMO1
  • PREL2
  • PREL-2
  • ALS2CR9
  • ALS2CR18
  • RalGDS/AF-6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.92
virus perturbation
0.76
cell line
0.75
cell type or tissue
0.73
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.41   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 66   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.41   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0